RT  - Journal of Clinical Pediatric Dentistry
ID  - 10.17796/1053-4625-46.3.12
T1  - Evidence of Association between MTRR and TNF-α Gene Polymorphisms and Oral Health Related Quality of Life in Children with Anterior Open Bite
A1  - Ellen Cardoso Teixeira
A1  - Bruno Moreira das Neves
A1  - Thuanny Castilho
A1  - Thayane Silva Ramos
A1  - Adriele Flaviana
A1  - Julia Carelli
A1  - Erika Calvano Kuchler
A1  - Fabiana Nunes Germano
A1  - Lívia Azeredo Alves Antunes
A1  - Leonardo Santos Antunes
K1  - Open bite; Malocclusion; Quality of life; Genetic polymorphism
YR  - 2022
SP  - 249
AB  - <p>Genetic polymorphisms could explain the inter-individual differences in the oral health-related quality of life (OHRQoL) of children with anterior open bite (AOB). <strong>Objective:</strong> To assess the impact of AOB on OHRQoL in children and to evaluate whether MTR (rs1805087), MTRR (rs1801394), TGFβ1 (rs1800469) and TNF-α (rs1799964, rs1799724 and rs1800629) genes are potential biomarkers for OHRQoL in children with AOB. <strong>Study design:</strong> A cross-sectional study was performed with 173 children aged between 2–6 years. The Brazilian version of Early Childhood Oral Health Impact Scale (ECOHIS) was applied. Genetic polymorphisms were analyzed using real-time PCR. Mann-Whitney U-test and Chi-square were used. <strong>Results:</strong> The overall mean ECOHIS scores were 5.49 (SD= 5.72) and 3.45 (SD = 4.49) (p &lt; 0.01) in the AOB and control groups, respectively. Children with the CC genotype of TNF-α (rs1799724) had a significantly higher psychological QoL level. The MTRR AA genotype group showed a lower QoL level in the child subscale (p = 0.006), function (p = 0.017), and psychological (p = 0.006) domains. There was no significant difference between OHRQoL and the genetic polymorphisms in MTR and TGFβ1. <strong>Conclusions:</strong> Genetic polymorphisms in TNF-α and MTRR are associated with the impact on the OHRQoL in children with AOB.</p>