Background: Childhood fever originating from dental issues is a potentially serious health concern affecting numerous children. This study aims to investigate its prevalence in Saudi Arabia and parental knowledge regarding its management. Methods: Using a self-administered questionnaire, 951 parents attending various centers in Saudi Arabia were recruited in this cross-sectional study between 01 September and 31 December 2023. Results: The questionnaire includes parents’ demographic characteristics and fever management practices. Nearly 65% of parents expressed concern about fever’s harmful effects, including potential loss of consciousness, dehydration and brain damage. Moreover, 64.2% of parents report consistently using antibiotics without a prescription. Conclusions: Our findings demonstrated a lack of knowledge among parents when it comes to managing their children’s dental-related fever. A proactive educational approach to addressing this concern is required by healthcare professionals, as well as the community at large.