RT - Journal of Clinical Pediatric Dentistry ID - 10.22514/jocpd.2025.122 T1 - Teething in infants: a structured review of symptomatology, parental misconceptions, and evidence-based management A1 - David K. Langford A1 - Marcio Guelmann A1 - Joseph Katz K1 - Teething; Syndrome; Pediatric; Dentistry; Management; Symptoms; Misconceptions; Inflammation; Infant YR - 2025 SP - 11 AB -

Teething is a common developmental milestone in infants, typically occurring between six and thirty months of age. Although generally associated with localized discomfort, current literature indicates that teething is frequently misattributed as a cause of systemic symptoms such as fever and diarrhea. This review synthesizes findings from existing literature on teething symptomatology, clarifies commonly held misconceptions and highlights the risks associated with inappropriate management strategies. A structured literature review was conducted using predefined criteria to identify relevant publications, including systematic reviews, meta-analyses, cohort studies, observational studies and professional health guidelines published between 1990 and 2024. The review focused on teething-related symptoms, caregiver beliefs and intervention outcomes. Current evidence supports a consistent association between teething and mild, localized symptoms including irritability, drooling and gum inflammation. Inflammatory cytokines such as interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α), found in gingival crevicular fluid, suggest a localized immune response. There is no credible evidence linking teething to high fever or gastrointestinal disturbances. Misconceptions—rooted in both historical practice and persistent caregiver beliefs—have contributed to the use of potentially harmful remedies, such as topical anesthetics and teething necklaces. According to current literature, teething is a benign, self-limited process that warrants conservative management. Caregiver education remains critical to reducing the use of unsafe remedies and avoiding delays in the diagnosis of unrelated illnesses. Pediatric dental providers are uniquely positioned to correct misinformation and promote safe, evidence-based approaches to teething.