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Clinical and Radiographic Evaluation of Formocresol and Chloramphenicol, Tetracycline and Zinc Oxide-Eugenol Antibiotic Paste in Primary Teeth Pulpotomies: 24 month follow up

  • Jesús Luengo-Fereira1,*,
  • Sergio Ayala-Jiménez2
  • Luz Elena Carlos-Medrano1
  • Iovanna Toscano-García1
  • Minerva Anaya-Álvarez1

1Pediatric Dentistry Postgraduate Program. School of Dentistry, Zacatecas Autonomous University, Mexico

2School of Dentistry, Juarez University of Durango State, Mexico

DOI: 10.17796/1053-4625-43.1.4 Vol.43,Issue 1,January 2019 pp.16-21

Published: 01 January 2019

*Corresponding Author(s): Jesús Luengo-Fereira E-mail: jluengo@uaz.edu.mx

Abstract

Objective: The purpose of the present study was to evaluate clinically and radiographically the effectiveness of formocresol and the antibiotic paste CTZ (chloramphenicol, tetracycline and zinc oxide-eugenol) in primary teeth pulpotomies, during a 6, 12 and 24 month period. Study design: A total of 80 pulpotomies were performed in 58 patients between three and six years of age. The patients were selected and assigned to two groups: Group I Formocresol (FC, n=40), Group II chloramphenicol-tetracycline-zinc oxide eugenol (CTZ, n=40). The teeth were restored with glass ionomer and pre-formed stainless steel crowns. The treated teeth were evaluated clinically and radiographically at 6, 12 and 24 months. Results: After 24 months of follow up a 100% and 94.3% clinical success was obtained, in the CTZ and formocresol groups respectively (x2= 0.450, p>0.05). The radiographic success was of 97.4% and 94.3% respectively (x2= 0.920, p>0.05). Conclusion: The performance of the antibiotic paste CTZ was superior to formocresol. No statistically significant differences were observed between the treatment groups either clinically or radiographically. More randomized clinical trials should be performed before it can be indicated safely.

Keywords

Primary molars; Pulpotomy; Formocresol; Antibiotic paste.

Cite and Share

Jesús Luengo-Fereira,Sergio Ayala-Jiménez,Luz Elena Carlos-Medrano,Iovanna Toscano-García,Minerva Anaya-Álvarez. Clinical and Radiographic Evaluation of Formocresol and Chloramphenicol, Tetracycline and Zinc Oxide-Eugenol Antibiotic Paste in Primary Teeth Pulpotomies: 24 month follow up. Journal of Clinical Pediatric Dentistry. 2019. 43(1);16-21.

References

1. Pimenta HC, Borges AH, Bandeca MC, Neves AT, Fontes RG, da Silva PV, Aranha AM. Antimicrobial activity of filling materials used in primary teeth pulpotomy. J Int Oral Health, 7 (4): 54-7, 2015.

2. Mariz P, Cavalcanti R, Alvez S. Clinical and radiographic monitoring of primary teeth submitted to pulp therapy with CTZ paste. Braz Res Ped Dent Int Clin, 14: 56-68, 2014.

3. Molina N, Durán D, Castañeda E, Juárez M. La caries y su relación con la higiene oral en preescolares mexicanos. Gac Med Mex, 151: 485-490, 2015.

4. Azevedo C, Barcelos R, Primo L. Variabilidade das técnicas de tratamento endodóntico em dentes decíduos para os procedimentos clínicos. Odont Clin Cient, 45 (1): 37-43, 2009.

5. Lin PY, CHen HS, Wang YH, Tu YK. Primary molar pulpotomy: A systematic review and network meta-analysis. J Dent, 42: 1060-1077, 2014.

6. Simancas-Pallares MA, Díaz-Caballero AJ, Luna- Ricardo LM. Mineral trioxide aggregate in primary teeth pulpotomy. A systematic literature review. Med Oral Patol Oral Cir Bucal, 15 (6): 942-946, 2010.

7. Gonzalez-lara A, Ruiz-Rodriguez M, Pierdant-Perez M, Garrocho-Rangel J, Pozos-Guillen A. Zinc Oxide-Eugenol pulpotomy in primary teeh: A

24- month follow-up. J Clin Ped Dent, 40 (2): 365-107-112, 2016.

8. Liu H, Zhou Q, Qin M. Mineral trioxide aggregate calcium hydroxide for pulpotomy in primary molars. Chin J Dent Res, 14 (2): 121-125, 2011.

9. Yildirim C, Basak F, Akgun O, Guven G, Altun C. Clinical and Radio-graphic Evaluation of the Effectiveness of Formocresol, Mineral Trioxide Aggregate, Portland Cement, and Enamel Matrix Derivative in Primary Teeth Pulpotomies: A Two Year Follow-Up. J Clin Ped Dent, 40 (1):

14- 20, 2016.

10. Oliveira TM, Moretti AB, Sakai VT, Lourenço Neto N, Santos CF, Machado MA. Clinical, radiographic and histologic analysis of the effects of pulp capping materials used in pulpotomies of human primary teeth. Eur Arch Paediatr Dent, 14 (2): 65-71, 2013.

11. Ranly DM. Pulpotomy therapy in primary teeth, new modalities for old rationales. Pediatr Dent, 16: 403-406, 1994.

12. Srinivasan V, Patchett L, Waterhouse P. Is there life after Buckley’s Formocresol? Part I, A narrative review of alternative interventions and materials. Int J Paediatr Dent, 16:117-127, 2006.

13. Chandrashekhar S, Shashidhar J. Formocresol, still a controversial material for pulpotomy: A critical literature review. J Res Dent, 2: 114-124, 2014.

14. Goyal P, Pandit IK, Gugnani N, Gupta M, Goel R, Gambhir RS. Clinical and radiographic comparison of various medicaments used for pulpotomy in primary molars: A randomized clinical trial. Eur J Dent, 10: 315-320, 2016.

15. Havale R, Anegundi R, Indushekar K, Sudha P. Clinical and Radiographic Evaluation of Pulpotomies In Primary Molars With Formocresol, Glutaraldehyde and Ferric Sulphate. OHDM, 12(1): 24-31, 2013.

16. Nishimura H, Higo Y, Ohno M, Tsutsui TW, Tsutsui T. Ability of root canal antiseptics used in dental practice to induce chromosome aberrations in human dental pulp cells. Mutat Res, 649: 45-53, 2008.

17. Zhang L, Steinmaus C, Eastmand D, Xin X, Smith M. Formaldehyde exposure and leukemia: a new meta-analysis and potential mechanisms. Mutat Res, 681: 150-168, 2009.

18. Zhang L, Freeman L, Nakamura J, Hecht SS, Vandenberg JJ, Smith MT, et al. Formaldehyde and leukemia: epidemiology, potential mechanisms and implications for risk assessment. Environ Mol Mutagen, 51: 181-191, 2010.

19. Goldstein B. Hematological and toxicological evaluation of formaldehyde as a potential cause of human leukemia. Hum Exp Toxicol, 30: 725- 735, 2011.

20. United States Department of Health and Human Services, Public Health Service. National Toxicology Program. Formaldehyde. In: 12th Report on Carcinogens. CAS No. 50-00-0. Available from: http://ntp.niehs.nih. gov/go/ roc12.

21. Waterhouse PJ. “New age” pulp therapy: personal thoughts on a hot debate. Pediatr Dent, 30: 247-252, 2008.

22. Subramaniam P, Gilhotra K. Endoflas, zinc oxide eugenol and metapex as root canal filling materials in primary molars: A comparative clinical study. J Clin Ped Dent, 35 (4): 365-370, 2011.

23. Pinky C, Shashibhuhshan K, Subbareddy V. Endodontic treatment of primary teeth using two different combinations of antibacterial drugs: an in vivo study. J Ind Soc Ped Prev Dent, 29 (2): 121-127, 2011.

24. Oliveira M, Costa L. Desempenho clínico de pulpotomías com pasta CTZ en molares deciduos: estudio retrospectivo. Robrac, 15 (40): 37-45, 2006.

25. Daher A, Alves K, Rodrigues C, Rezende L. Ineffectiveness of Antibiotic-Based Pulpotomy for Primary Molars: a Survival Analysis. Braz Res Pediat Dent and Integr Clin, 15(1): 205-215, 2015.

26. Passos I, Melo J, Moreira P. Utilizacao da pasta CTZ em demte decíduo com necrose pulpar – relato de caso. Odont Clin Cient, 7 (1): 63-65, 2008.

27. Siegl R, Lenzi T, Politano G, De Benedetto M, Imparato J, Pinheiro S. Two endodontics techniques analysis in primary molars with fistula. RGO, 63 (2): 187-194, 2015.

28. Luengo J, Ramos A, Hernandez M, Diaz C, Carlos L, Toscano I. Clinical and radiographic effectiveness of antibiotic paste CTZ in primary molars pulpotomy. Ramdomized Controlled Clinical Trial. Int J Odontostomat, 10 (3): 425-431, 2016.

29. Reis B, Barbosa C, Soares L, Brum S, Barbosa O, Marques M. In vitro analysis of antimicrobial activity of CTZ binder used as material plug in deciduous teeth pulp. R Pró-Uni, 7 (3): 39-42, 2016.

30. Mylonas I. Antibiotic chemotherapy during pregnancy and lactation period: aspects for consideration. Arch Gynecol Obstet, 283: 7-18, 2011.

31. Sánchez M, Thong B, Blanca M, Chiverini L, Gonzalez S, Greenberger P, et al. Hypersensitivity reactions to non beta-lactam antimicrobial agents, a statement of the WAO special committee on drug allergy. World Allergy Organ J, 6: 18, 2013.

32. Silva C, Leache E. Utilização do agregado trióxido mineral (MTA) em pulpotomias de molares temporários. Dent Clín, 70 (1): 34-37, 2010.

33. World Medical Association Declaration of Helsinki Ethical Principles for Medical Research Involving Human Subjects. JAMA, 310 (20): 2191-2194, 2013.

34. Nanda R, Koul M, Srivastava S, Upadhyay V, Dwivedi R. Clinical evaluation of 3 Mix and Other Mix in non-instrumental endodontic treatment of necrosed primary teeth. J Oral Biol Craniof Res, (4): 114-119, 2014.

35. Alolofi H, El-Sayed M, Taha S. Clinical and radiographical evaluation of propolis and thymus vulgaris extracts compared with formocresol pulpotomy in human primary molars. BDJOPEN, 2: 1-6, 2016.

36. Bruno G, Menezes V, Bruno J, Almeida M, Viana G. Hematological and biochemical evaluations of blood from dogs submitted to pulpotomies with an antibiotic sealer. Rev Odontol UNESP, 35(3): 125-133, 2006.

37. Ruby JD, Cox CF, Mitchell SC, Makhija S, Chompu-Inwai P, Jackson J. A randomized study of sodium hypochlorite versus formocresol pulpotomy in primary molar teeth. Int J Paediatr Dent, 13:1-8, 2012.

38. Aminabadi N, Zadeh R, Ghertasi S. Formocresol versus calcium hydroxide direct pulp capping. J Clin Ped Dent, 34(4): 317-321, 2010.

39. Sunitha B, Puppala R, Kethineni B, Mallela MK, Peddi R, Tarasingh

P. Clinical and Radiographic Evaluation of Four Different Pulpotomy Agents in Primary Molars: A Longitudinal Study. Int J Clin Pediatr Dent, 10(3): 240-244, 2017.

40. Juneja P, Kulkarni. Clinical and radiographic comparision of biodentine, mineral trioxide aggregate and formocresol as pulpotomy agents in primary molars. Eur Arch Paediatr Dent, 18:271-278, 2017.

41. Ansari G, Ranjpour M. Mineral trioxide aggregate and formocresol of primary teeth: a 2-year follow-up. Int Endod J, 43: 410-418, 2010.

42. Takushige T, Cruz E, Moral M, Hoshino E. Non-surgical treatment of pulpitis, including those with history of spontaneous pain, using a combination of antibacterial drugs. J LSTR, 7: 1-5, 2008.

43. Takushige T, Hoshino E. Endodontic retreatment using 3Mix- MP without removal of previous root canal obturation. J LSTR, 8: 3-7, 2009.

44. Nakornchai S, Banditsing P, Visetratana N. Clinical evaluation of 3 Mix and vitapex as treatment options for pulpally involved primary molars. Int J Paediatr Dent, 20: 214-221, 2010.

45. Trairatvorakul C, Detsomboonrat P. Success rates of a mixture of ciprofloxacin, metronidazole, and minocycline antibiotics used in the non-instrumentation endodontic treatment of mandibular primary molars with carious pulpal involvement. Int J Paediatr Dent, 22(3): 217-227, 2012.


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