Article Data

  • Views 979
  • Dowloads 152

Original Research

Open Access

Prevalence of Hypodontia in Unilateral and Bilateral Cleft Lip and Palate Patients Inside and Outside Cleft Area: A Case-Control Study

  • Alberto De Stefani1,*,
  • Giovanni Bruno1
  • Paolo Balasso2
  • Sergio Mazzoleni1
  • Ugo Baciliero3
  • Antonio Gracco1

1Faculty of Dentistry, From the University of Padova, Italy

2Department of Management and Engineering, From the University of Padova, Italy

3Department of Maxillofacial Surgery, Regional Hospital of Vicenza, Vicenza, Italy

DOI: 10.17796/1053-4625-43.2.10 Vol.43,Issue 2,March 2019 pp.126-130

Published: 01 March 2019

*Corresponding Author(s): Alberto De Stefani E-mail: alberto.de.stefani@hotmail.it

Abstract

Objectives: The aim of this study is to evaluate the prevalence and distribution of hypodontia, inside and outside the cleft area, in an Italian population with a non-syndromic unilateral (UCLP) and bilateral (BCLP) cleft lip and palate on panoramic radiographs and comparing it with a control sample. Study design: Case group was ethnically uniform and consisted in 233 patients. The control group was composed of 1000 subjects. Patients included were between seven and fifteen years old. Descriptive analysis, using absolute and relative frequencies, was performed to check out the prevalence of gender distribution, hypodontia and cleft formation. Statistical analysis was conducted with Chi-squared test, Yate's correction and the Fisher's exact test. The power was set higher than 0.8 for each test. Results: 160 cleft patients (68.68%) presented at least one missing tooth, while 88 patients in the control groups presented agenesis (8.80%). A statistically significant difference was found in case and control groups for upper lateral incisors (37.34% and 48.07% in the case group against 2.50% and 2.60% in the control group), upper and lower second premolars (8.58%, 6.44%, 5.58% and 6.01% in the cleft group and 0.60%, 0.60%, 2.50% and 2.70% in the control group). Conclusion: Higher prevalence of dental agenesis in the maxillary dental arch is explained by the cleft defect. Higher prevalence of mandibular second premolars agenesis cannot be explained by the anatomical defect and suggests a multifactorial aetiology, including environmental and genetic factors, of the cleft condition.

Keywords

Cleft; Hypodontia

Cite and Share

Alberto De Stefani,Giovanni Bruno,Paolo Balasso,Sergio Mazzoleni,Ugo Baciliero,Antonio Gracco. Prevalence of Hypodontia in Unilateral and Bilateral Cleft Lip and Palate Patients Inside and Outside Cleft Area: A Case-Control Study. Journal of Clinical Pediatric Dentistry. 2019. 43(2);126-130.

References

1. Rajion ZA, Alwi Z. Genetics of cleft lip and palate: a review. Malays J Med Sci;14(1):4–9. 2007.

2. Farronato G, Cannalire P, Martinelli G, et al. Cleft lip and/or palate: review. Minerva Stomatol;63(4):111–26. 2014.

3. Stuppia L, Capogreco M, Marzo G, et al. Genetics of syndromic and nonsyndromic cleft lip and palate. J Craniofac Surg;22(5):1722–6. 2011.

4. Tolarová MM, Cervenka J. Classification and birth prevalence of orofacial clefts. Am J Med Genet;75(2):126–37. 1998.

5. Chung CS, Myrianthopoulos NC. Racial and prenatal factors in major congenital malformations. Am J Hum Genet;20(1):44–60. 1968.

6. Leck I. The geographical distribution of neural tube defects and oral clefts. Br Med Bull;40(4):390–5. 1984.

7. Tyan ML. Differences in the reported frequencies of cleft lip plus cleft lip and palate in Asians born in Hawaii and the continental United States. Proc Soc Exp Biol Med;171(1):41–5. 1982.

8. Agbenorku P, Agbenorku M, Iddi A, et al. A study of cleft lip/palate in a community in the South East of Ghana. Eur J Plast Surg;34(4):267–72. 2011.

9. Rodríguez Dehli C, Mosquera Tenreiro C, García López E, et al. [The epidemiology of cleft lip and palate over the period 1990-2004 in Asturias]. An Pediatr (Barc);73(3):132–7. 2010.

10. Sá J, Mariano LC, Canguçu D, et al. Dental Anomalies in a Brazilian Cleft Population. Cleft Palate-Craniofacial J;53(6):714–9. 2016.

11. Omo-Aghoja VW, Omo-Aghoja LO, Ugboko VI, et al. Antenatal determinants of oro-facial clefts in Southern Nigeria. Afr Health Sci;10(1):31–9. 2010.

12. Berniczei-Royko A, Tappe J-H, Krinner A, et al. Radiographic Study of the Prevalence and Distribution of Hypodontia Associated with Unilateral and Bilateral Clef Lip and Palate in a Hungarian Population. Med Sci Monit;22:3868–85. 2016.

13. Tortora C, Meazzini MC, Garattini G, Brusati R. Prevalence of abnormalities in dental structure, position, and eruption pattern in a population of unilateral and bilateral cleft lip and palate patients. Cleft Palate Craniofac J;45(2):154–62. 2008.

14. Paranaiba LMR, Coletta RD, Swerts MSO, Quintino RP, de Barros LM, Martelli-Júnior H. Prevalence of Dental Anomalies in Patients With Nonsyndromic Cleft Lip and/or Palate in a Brazilian Population. Cleft Palate-Craniofacial J;50(4):400–5. 2013.

15. Ghassibe M, Bayet B, Revencu N, et al. Orofacial clefting: update on the role of genetics. B-ENT;2 Suppl 4:20–4. 2006.

16. Shapira Y, Lubit E, Kuftinec MM. Hypodontia in children with various types of clefts. Angle Orthod;70(1):16–21. 2000.

17. Kavadia S, Papadiochou S, Papadiochos I, Zafiriadis L. Agenesis of maxillary lateral incisors: a global overview of the clinical problem. Orthodontics (Chic);12(4):296–317. 2011.

18. Camporesi M, Baccetti T, Marinelli A, Defraia E, Franchi L. Maxillary dental anomalies in children with cleft lip and palate: a controlled study. Int J Paediatr Dent;20(6):442–50. 2010.

19. Lourenço Ribeiro L, Teixeira Das Neves L, Costa B, Ribeiro Gomide M. Dental anomalies of the permanent lateral incisors and prevalence of hypodontia outside the cleft area in complete unilateral cleft lip and palate. Cleft Palate Craniofac J;40(2):172–5. 2003.

20. Suzuki A, Takahama Y. Maxillary Lateral Incisor of Subjects with Cleft Lip and/or Palate: Part 1. Cleft Palate-Craniofacial J;29(4):376–9. 1992.

21. Menezes R, Vieira AR. Dental anomalies as part of the cleft spectrum. Cleft Palate Craniofac J;45(4):414–9. 2008.

22. Mangione F, Nguyen L, Foumou N, Bocquet E, Dursun E. Cleft palate with/ without cleft lip in French children: radiographic evaluation of prevalence, location and coexistence of dental anomalies inside and outside cleft region. Clin Oral Investig 2017. Jun 7.

23. Moorrees cf, fanning ea, hunt ee. Age variation of formation stages for ten permanent teeth. J dent res 42:1490–502, 1963.

24. Daito M, Tanaka T, Hieda T. Clinical observations on the development of third molars. J Osaka Dent Univ;26(2):91–104. 1992.

25. Mattheeuws N, Dermaut L, Martens G. Has hypodontia increased in Caucasians during the 20th century? A meta-analysis. Eur J Orthod;26(1):99–103. 2004.

26. Ranta R. A review of tooth formation in children with cleft lip/palate. Am J Orthod Dentofacial Orthop;90(1):11–8. 1986.

27. Jiroutová O, Müllerová Z. The occurrence of hypodontia in patients with cleft lip and/or palate. Acta Chir Plast;36(2):53–6. 1994.

28. Eerens K, Vlietinck R, Heidbüchel K, et al. Hypodontia and tooth formation in groups of children with cleft, siblings without cleft, and nonrelated controls. Cleft Palate Craniofac J;38(4):374–8. 2001.

29. Letra A, Menezes R, Granjeiro JM, Vieira AR. Defining subphenotypes for oral clefts based on dental development. J Dent Res;86(10):986–91. 2007.

30. De Stefani A, Bruno G, Balasso P, Mazzoleni S, Baciliero U, Gracco A. Teeth agenesis evaluation in an Italian sample of complete unilateral and bilateral cleft lip and palate patients. Minerva Stomatol. 2018 Jan 31 doi: 10.23736/S0026-4970.18.04114-6.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Scopus: CiteScore 1.8 (2023) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Submission Turnaround Time

Conferences

Top