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Original Research

Open Access

Levels of Cytokines in Gingival Crevicular Fluid during Rapid Maxillary Expansion and the Subsequent Retention Period

  • Sıla Çağlayan Topal1
  • Burcu Balos Tuncer2,*
  • Serenay Elgun3
  • Imge Erguder3
  • Nurdan Ozmeric4

1Private practice, Bayındır Hospital, Ankara, Turkey

2Gazi University, Faculty of Dentistry, Department of Orthodontics, Ankara, Turkey

3Ankara University, Faculty of Medicine, Department of Medical Biochemistry, Ankara, Turkey

4Gazi University, Faculty of Dentistry, Department of Periodontology, Ankara, Turkey

DOI: 10.17796/1053-4625-43.2.12 Vol.43,Issue 2,March 2019 pp.137-143

Published: 01 March 2019

*Corresponding Author(s): Burcu Balos Tuncer E-mail: burcubalostuncer@yahoo.com

Abstract

Objective: To monitor the effects of rapid maxillary expansion (RME) on bone metabolic activities during and after 3 months of retention. Study Design: Fifteen patients with a mean age of 12.9 ± 0.6 years were treated with a bonded expansion device, activated 2 turns per day. The retention period was 3 months. Clinical periodontal parameters were recorded at baseline and after retention. Gingival crevicular fluid (GCF) samples were collected from maxillary first molars from the compression sides at baseline, then at 1 and 10 days and after retention. Tension side samples were obtained at baseline and after retention. Interleukin-1beta (IL-1β), transforming growth factor beta1 (TGF-β1), prostaglandin E2 (PGE2) and nitric oxide (NO) levels were specifically measured. Results: Periodontal parameters increased significantly after retention relative to baseline values. Levels of IL-1β, TGF-β1 and PGE2 increased on day 10, and decreased after retention on the compression side. NO levels were elevated on day 10, and remained higher after retention on the compression side. Tension side cytokine levels remained higher relative to baseline values after retention. Conclusions: The results of this study indicate the importance of ongoing adaptive bone activities after 3 months of retention with RME, which should be considered questionable as an effective retention period.

Keywords

Rapid maxillary expansion; Gingival crevicular fluid; Bone remodeling; Retention

Cite and Share

Sıla Çağlayan Topal,Burcu Balos Tuncer,Serenay Elgun,Imge Erguder,Nurdan Ozmeric. Levels of Cytokines in Gingival Crevicular Fluid during Rapid Maxillary Expansion and the Subsequent Retention Period. Journal of Clinical Pediatric Dentistry. 2019. 43(2);137-143.

References

1. Ahrari F, Eslami N. Non surgical treatment of maxillary deficiency using tongue guard appliance:a case report. J Dent Res Dent Clin Dent Prospects 5: 136-40, 2011.

2. Vardimon AD, Brosh T, Spiegler A, Lieberman M, Pitaru S. Rapid palatal expansion:Part 1.Mineralization pattern of the midpalatal suture in cats. Am J Orthod Dentofacial Orthop 113: 371-8, 1998.

3. Lagravere MO, Major PW, Flores-Mir C. Long-term skeletal changes with rapid maxillary expansion: a systematic review. Angle Orthod 75: 1046–52, 2005.

4. Ferris T, Alexander RG, Boley J, Buschang PH. Long-term stability of combined rapid palatal expansion-lip bumper therapy followed by full fixed appliances. Am J Orthod Dentofacial Orthop 128: 310–25, 2005.

5. Küçükkeleş N, Ceylanoğlu C. Changes in lip, cheek, and tongue pressures after rapid maxillary expansion using a diaphragm pressure transducer. Angle Orthod 73: 662-8, 2003.

6. Korbmacher H, Huck L, Merkle T, Kahl-Nieke B. Clinical profile of rapid maxillary expansion–outcome of a national inquiry. J Orofac Orthop 66: 455–68, 2005.

7. Franchi L, Baccetti T, Lione R, Fanucci E, Cozza P. Modifications of midpalatal sutural density induced by rapid maxillary expansion:A low-dose computed-tomography evaluation. Am J Orthod Dentofacial Orthop 137: 486–8, 2010.

8. Bishara SE, Taley RN. Maxillary expansion:clinical implications. Am J Orthod Dentofacial Orthop 91: 3-14, 1987.

9. Bianchi A, Amadori S, Pironi M, Marchetti C. Maxillary expansion and stability in the orthodontic-surgical treatment of skeletal anterior open bites. Prog Orthod 10: 26-37, 2009.

10. Garlet TP, Coelho U, Silva JS, Garlet GP. Cytokine expression pattern in compression and tension sides of the periodontal ligament during orthodontic tooth movement in humans. Eur J Oral Sci 115: 355-62, 2007.

11. Meeran NA. Cellular response within the periodontal ligament on application of orthodontic forces. J Indian Soc Periodontol 17: 16-20, 2013.

12. Feller L, Khammissa RA, Schechter I, Thomadakis G, Fourie J, Lemmer J. Biological events in periodontal ligament and alveolar bone associated with application of orthodontic forces. Scientific World Journal 2015: 876509. doi: 10.1155/2015/876509, 2015.

13. Krishnan V, Davidovich Z. On a path to unfolding the biological mechanisms of orthodontic tooth movement. J Dent Res 88: 597-608, 2009.

14. Griffiths GS, Moulson AM, Petrie A, James IT. Evaluation of osteocalcin and pyridinium cross links of bone collagen as markers of bone turnover in gingival crevicular fluid during different stages of orthodontic treatment. J Clin Periodontol 25: 492-8, 1998.

15. Lee KJ, Park YC, Yu HS, Choi SH, Yoo YJ. Effects of continuous and interrupted orthodontic force on interleukin-1 beta and prostoglandin E2 production in gingival crevicular fluid. Am J Orthod Dentofacial Orthop 125: 168-77, 2004.

16. Alhashimi N, Frithiof L, Brudvik P, Bakhiet M. Orthodontic tooth movement and de novo synthesis of proinflammatory cytokines. Am J Orthod Dentofacial Orthop 119: 301–12, 2001.

17. Tzannetou S, Efstratiadis S, Nicolay O, Grbic J, Lamster I. Interleukin-1beta and beta-glucuronidase in gingival crevicular fluid from molars during palatal expansion. Am J Orthod Dentofacial Orthop 115: 686-96, 1999.

18. Tzannetou S, Efstratiadis S, Nicolay O, Grbic J, Lamster I. Comparison of levels of inflammatory mediators IL-1beta and betaG in gingival crevicular fluid from molars, premolars, and incisors during rapid palatal expansion. Am J Orthod Dentofacial Orthop 133: 699-707, 2008.

19. Ballanti F, Lione R, Fanucci E, Franchi L, Bacetti T, Cozza P. Immediate and post-retention effects of rapid maxillary expansion investigated by computed tomography in growing patients. Angle Orthod 79: 24-9, 2009.

20. Garib DG, Henriques JF, Janson G, de Freitas MR, Fernandes AY. Periodontal effects of rapid maxillary expansion with tooth-tissue-borne and tooth-borne expanders: a computed tomography evaluation. Am J Orthod Dentofacial Orthop 129: 749-58, 2006.

21. Perinetti G, D’Apuzzo F, Contardo L, Primozic J, Rupel K, Perillo L. Gingival crevicular fluid alkaline phosphate activity during the retention phase of maxillary expansion in prepubertal subjects: A split mouth longitudinal study. Am J Orthod Dentofacial Orthop 148: 90-6, 2015.

22. Silness J, Löe H. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta Odontol Scand 22: 121–35, 1964.

23. Löe H. The gingival index, the plaque index and the retention index systems. J Periodontol 38: 610–6, 1967.

24. Ainamo J, Bay I. Problems and proposals for recording gingivitis and plaque. Int Dent J 25: 229-35, 1975.

25. Timms DJ, Preston CB, Daly PF. A computed tomographic assessment of maxillary induced by rapid expansion-a pilot study. Eur J Orthod 4: 123- 7, 1982.

26. Ren Y, Maltha JC, Van’t Hof MA, Von Den Hoff JW, Kuijpers-Jagtman AM, Zhang D. Cytokine levels in gingival crevicular fluid are less responsive to orthodontic force in adults than in juveniles. J Clin Periodontol 29: 752–62, 2002.

27. Rygh P Elimination of hyalinized periodontal tissues associated with orthodontic movement. Scand J Dent Res 82: 57-73, 1974.

28. Sari E, Kadioglu O, Ucar C, Altug HA. Prostaglandin E2 levels in gingival crevicular fluid during tooth- and bone-borne expansion. Eur J Orthod 32: 336- 41, 2010.

29. Guo J, Wang L, Xu H, Che X. Effect of heterologous bone marrow mononuclear cell transplantation on midpalatal expansion in rats. Exp Ther Med 9: 1235-40, 2015.

30. Itonaga I, Sabokbar A, Sun SG, Kudo O, Danks L, Ferguson D, et al. Transforming growth factor-beta induces osteoclast formation in the absence of RANKL. Bone 34: 57-64, 2004.

31. Juárez P, Guise TA. TGF-β in cancer and bone: Implications for treatment of bone metastases. Bone 48: 23–9, 2011.

32. Maeda S, Hayashi M, Komiya S, Imamura T, Miyazono K. Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells. EMBO J 23: 552–63, 2004.

33. Lamora A, Talbot J, Mullard M, Brunais-Le Royer B, Redini F, Verrecchia F. TGF-β signaling in bone remodeling and osteosarcoma progression. J Clin Med 3: doi: 10.3390/jcm5110096, 2016.

34. Fox SW, Evans KE, Lovibond AC. Transforming growth factor-beta enables NFATc1 expression during osteoclastogenesis. Biochem Biophys Res Commun 366: 123-8, 2008.

35. Balooch G, Balooch M, Nalla RK, Schilling S, Filvaroff EH, Marshall GW, et al. TGF-beta regulates the mechanical properties and composition of bone matrix. Proc Natl Acad Sci USA 27: 18813-8, 2005.

36. D’Attillio M, Di Maio F, D’Arcangela C, Filippi MR, Felaco M, Lohinai Z, et al. Gingival endothelial and inducible nitric oxide synthase levels during orthodontic treatment: a cross-sectional study. Angle Orthod 74: 851- 8, 2004.

37. Tan SD, Xie R, Klein-Nulend J, van Rheden RE, Bronckers AL, Kuijpers-Jagtman AM, et al. Orthodontic force stimulatese NOS and iNOS in rat osteocytes. J Dent Res 88: 255-60, 2009.

38. Baloul SS. Osteoclastogenesis and osteogenesis during tooth movement. Front Oral Biol 18: 75-9, 2016.

39. D’Attilio M, De Angelis F, Vadini M, Rodolfino D, Trubiani O, Di Nardo Di Maio F, et al. Endodontic-orthodontic relationships: expression of no synthase in human dental pulp during orthodontic tooth movement. J Biol Regul Homeost Agents 26: 35-43, 2012.

40. Çörekçi B, Göyenç YB. Dentofacial changes from fan-type rapid maxillary expansion vs traditional rapid maxillary expansion in early mixed dentition. Angle Orthod 83: 842-50, 2013.

41. Schauseil M, Ludwig B, Zorkun B, Hellak A, Korbmacher-Steiner H. Density of the midpalatal suture after RME treatment – a retrospective comparative low-dose CT-study. Head Face Med 20: 10:18, 2014. doi: 10.1186/1746-160X-10-18.

42. Ford H, Suri S, Nilforoushan D, Manolson M, Gong SG. Nitric oxide in human gingival crevicular fluid after orthodontic force application. Arch Oral Biol 59: 1211-6, 2014.


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