Article Data

  • Views 824
  • Dowloads 184

Original Research

Open Access

Remineralizing Potential of Clinpro® and Tooth Mousse Plus® on Artificial Carious Lesions

  • Sakshi Buckshey1
  • Robert P Anthonappa2,*,
  • Nigel M. King2
  • Anut Itthagarun3

1Henry M Goldman School of Dental Medicine, Boston University, USA

2Paediatric Oral Health Research Group, School of Dentistry, The University of Western Australia, Australia

3Paediatric Dentistry, School of Dentistry and Oral Health, Griffith University, Gold Coast, Australia

DOI: 10.17796/1053-4625-43.2.6 Vol.43,Issue 2,March 2019 pp.103-108

Published: 01 March 2019

*Corresponding Author(s): Robert P Anthonappa E-mail: robert.anthonappa@uwa.edu.au

Abstract

Background: Calcium phosphate and fluoride (F) delivery systems claim to facilitate enamel remineralization. Aim: To evaluate and compare (i) the remineralizing potential of Clinpro® Tooth Crème(CTC) and Tooth Mousse Plus®(TMP) on artificial carious lesions, and (ii) the benefit of 1000ppm F dentifrice prior to the application of CTC and TMP. Study design: Carious lesions, 200–300μm deep were produced by placing molars in demineralizing solution for 96h, sections 100–150μm thick were then randomly assigned to six groups(n=150). Specimens were treated thrice daily with a non-fluoridated(Group A), or fluoridated dentifrice[1000ppm, (Group B)], or CTC(Group C), TMP(Group D), fluoridated dentifrice followed by CTC(Group E), or a fluoridated dentifrice followed by TMP(Group F), and then subjected to a 10-day pH cycling model. Lesion evaluation involved polarizing light microscopy and microradiography. Results: Posttreatment maximum mineral content at the surface zone(Vmax) was significantly increased in Groups B, C, and D compared to the other groups. The lesion depth(LD) decreased in Group D>Group C>Group E, and the net mineral content gain(ΔZ) in Group C>Group D, which did not reach statistical significance. Conclusions: CTC and TMP exhibited similar efficacy in remineralizing artificial carious lesions. Nevertheless, the net mineral gain or lesion consolidation following CTC use was higher than TMP.

Keywords

Remineralization; Tooth mousse plus, Clinpro

Cite and Share

Sakshi Buckshey,Robert P Anthonappa,Nigel M. King,Anut Itthagarun. Remineralizing Potential of Clinpro® and Tooth Mousse Plus® on Artificial Carious Lesions. Journal of Clinical Pediatric Dentistry. 2019. 43(2);103-108.

References

1. Cochrane NJ, Reynolds EC. Calcium phosphopeptides — mechanisms of action and evidence for clinical efficacy. Adv Dent Res; 24: 41-47. 2012.

2. Karlinsey RL, Mackey AC, Walker ER et al. Surfactant-modified beta-TCP: structure, properties, and in vitro remineralisation of subsurface enamel lesions. J Mater Sci Mater Med; 21: 2009–2020. 
2010.

3. Karlinsey RL, Mackey AC, Stookey GK. In vitro remineralisation efficacy of NaF systems containing unique forms of calcium. Am J Dent; 22: 185–188. 2009.

4. Karlinsey RL, Mackey AC, Stookey GK et al. In vitro assessments of experimental NaF dentifrices containing a prospective calcium phosphate technology. Am J Dent; 22: 180–184. 2009.

5. Mensinkai PK, Ccahuana-Vasquez RA, Chedjieu I et al. In situ remineralisation of white-spot enamel lesions by 500 and 1,100 ppm F dentifrices. Clin Oral Investig; 16: 1007–1014. 2012.

6. Karlinsey RL, Pfarrer AM. Fluoride plus functionalized b-TCP: a promising combination for robust remineralisation. Adv Dent Res; 24: 48–52. 2012.

7. Kargul B, Altinok B, Welbury R. The effect of casein phosphopeptide-amorphous calcium phosphate on enamel surface rehardening. An in vitro study. Eur J Paediatric Dent; 13: 123-127. 2012.

8. Cochrane NJ, Saranathan S, Cai F, Cross KJ, Reynolds E. Enamel subsurface lesion remineralisation with casein phosphopeptide stabilised solutions of calcium, phosphate and fluoride. Caries Res; 42: 88-97. 2008.

9. Ogata K, Warita S, Shimazu K, Kawakami T, Aoyagi K, Karibe H. Combined effect of paste containing casein phosphopeptide-amorphous calcium phosphate and fluoride on enamel lesions: an in vitro pH-cycling study. Pediatr Dent ; 32: 433-438. 2010.

10. Shen P, Manton D, Cochrane N et al. Effect of added calcium phosphate on enamel remineralisation by fluoride in a randomized controlled in situ trial. J Dent; 39: 518-525. 2011.

11. Vanichvatana S, Auychai P. Efficacy of two calcium phosphate pastes on the remineralisation of artificial caries: a randomized controlled double-blind in situ study. Int J Oral Sci; 5: 224-228. 2013.

12. Raphael S, Blinkhorn A. Is there a place for Tooth Mousse in the prevention and treatment of early dental caries? A systematic review. BMC Oral Health; 15: 113. 2015.

13. Snedecor GW, Cochran WG. Statistical methods. 8th ed. Ames: Iowa State University Press; 1989.

14. Itthagarun A, Wei SH, Wefel JS. The effect of different commercial dentifrices on enamel lesion progression: an in vitro pH-cycling study. Int Dent J; 50: 21-28. 2000.

15. Itthagarun A, King NM, Yiu C, Dawes C. The effect of chewing gums containing calcium phosphates on the remineralisation of artificial caries-like lesions in situ. Caries Res; 39: 251-254. 2005.

16. Kumar VL, Itthagarun A, King NM. The effect of casein phosphopeptide-amorphous calcium phosphate on remineralisation of artificial caries-like lesions: an in vitro study. Aust Dent J; 53: 34-40. 2008.

17. ten Cate JM, Duijsters PP. Alternating demineralization and remineralisation of artificial enamel lesions. Caries Res; 16: 201-210. 1982.

18. Bhat SS, Hegde KS, Habibullah MA, Bernhardt V. Incipient enamel lesions remineralisation using casein phosphopeptide amorphous calcium phosphate cream with and without fluoride: a laser fluorescence study. J Clin Pediatr Dent; 36: 353-356. 2012.

19. Margolis HC, Moreno EC. Physicochemical perspectives on the cariostatic mechanisms of systemic and topical fluorides. J Dent Res. 1990; 69: 606-613.

20. Arends J, Christoffersen J. Nature and role of loosely bound fluoride in dental caries. J Dent Res; 69: 601-605. 1990.

21. Gopalakrishnan VL, Anthonappa RP, King NM, Itthagarun A. Remineralising potential of a 60-s in vitro application of Tooth Mousse Plus. Int J Paediatr Dent. 2016 Sep 23. doi: 10.1111/ipd.12268. [Epub ahead of print]

22. Featherstone JD, Glena R, Shariati M, Shields CP. Dependence of in vitro demineralization of apatite and remineralisation of dental enamel on fluoride concentration. J Dent Res; 69: 620-625. 1990.

23. Hicks J, Garcia-Godoy F, Flaitz C. Biological factors in dental caries enamel structure and the caries process in the dynamic process of demineralization and remineralisation (part 2). J Clin Pediatr Dent; 28: 119-124. 2004.

24. Iijima Y, Cai F, Shen P, Walker G, Reynolds C, Reynolds EC. Acid resistance of enamel subsurface lesions remineralised by a sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate. Caries Res; 38: 551-556. 2004.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

PubMed (MEDLINE) PubMed comprises more than 35 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Scopus: CiteScore 2.0 (2022) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Submission Turnaround Time

Conferences

Top