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Original Research
Open AccessPrevalence of Dental Enamel Defects, Aphthous-Like Ulcers and
Other Oral Manifestations in Celiac Children and Adolescents: A
Comparative Study
Prevalence of Dental Enamel Defects, Aphthous-Like Ulcers and Other Oral Manifestations in Celiac Children and Adolescents: A Comparative Study
- Michail Zoumpoulakis1
- Maria Fotoulaki2
- Vasiliki Topitsoglou3
- Panagiota Lazidou4
- Lambros Zouloumis5
- Nikolaos Kotsanos6
1Hospital Dentistry, Aristotle University of Thessaloniki, Papaoikonomou 3, Heraklion Crete, Greece
2Department of Pediatrics, Aristotle University of Thessaloniki, Papageorgiou Gen. Hospital, Thessaloniki, Greece
3Department of Preventive Dentistry, Periodontology and Implant Biology, Aristotle University of Thessaloniki, Thessaloniki, Greece
4Laboratory of Immunology-Histocompatibility, Papageorgiou Gen.Hospital, Thessaloniki, Greece
5Department of Oral and Maxillofacial Surgery, Aristotle University of Thessaloniki, Thessaloniki, Greece
6Department of Pediatric Dentistry, Aristotle University of Thessaloniki, Thessaloniki, Greece
Abstract
Objectives: Celiac disease (CD) is an autoimmune disease with typical, atypical and asymptomatic forms, in which many oral manifestations have been recognized. This study aims to evaluate the prevalence of oral manifestations as well as explore if oral examination could be used as a first diagnostic screening tool for atypical or asymptomatic forms. Study Design: 45 CD patients, between 2 and 18 years (mean age 10.3) and 45 healthy subjects, age and gender-matched, were examined for hard and soft tissue lesions such as dental enamel defects (DED), dental caries, aphthous-like ulcers (ALU), atrophic glossitis, geographic tongue, median rhomboid glossitis. Results: Statistically significant differences between the two groups were observed for the prevalence of DED (in 64,4% CD and 24,46% control patients, p=0.001), their location in the teeth (incisal: p=0.0001, middle: p=0.002, cervical: p=0.007), as well as for the prevalence of ALU (in 40% CD as opposed to 4,44% control patients, p=0.001). Conclusion: The presence of DED and ALU could be used as a sign of alert for possible atypical and asymptomatic forms of CD.
Keywords
Celiac disease; Dental enamel defects; Aphthous-like ulcers
Cite and Share
Michail Zoumpoulakis,Maria Fotoulaki,Vasiliki Topitsoglou,Panagiota Lazidou,Lambros Zouloumis,Nikolaos Kotsanos. Prevalence of Dental Enamel Defects, Aphthous-Like Ulcers and Other Oral Manifestations in Celiac Children and Adolescents: A Comparative Study. Journal of Clinical Pediatric Dentistry. 2019. 43(4);274-280.
References
1. Pastore L, Carroccio A, Compilato D, Panzarella V, Serpico R, Lo Muzio L. Oral Manifestations of Celiac Disease. J Clin Gastroenterol; 42: 224–32. 2008.
2. Husby S, Koletzko S, Korponay-Szabó IR, Mearin ML, Phillips A, Shamir R, Troncone R, Giersiepen K, Branski D, Catassi C, Lelgeman M, Mäki M, Ribes-Koninckx C, Ventura A, Zimmer KP; ESPGHAN Working Group on Coeliac Disease Diagnosis; ESPGHAN Gastroenterology Committee; European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr. Jan; 54(1):136- 60. 2012.
3. Karlin S, Karlin E, Meiller T, Bashirelahi N. Dental and Oral Considerations in Pediatric Celiac Disease. J Dent Child (Chic); 83(2):67-70. 2016.
4. Paul SP, Kirkham EN, John R, Staines K, Basude D. Coeliac disease in children- an update for general dental practitioners. Br Dent J; 220(9): 481-85. 2016.
5. van Gils T, Brand HS, de Boer NKH, Mulder CJJ, Bouma G. Gastrointestinal diseases and their oro-dental manifestations: Part 3: Coeliac disease. Br Dent J.; 222(2):126-29. 2017.
6. worldgastroenterology.org [homepage on the internet]. Milwaukee: World Gastroenterology Organisation 2016; c2017 [Cited 2017 September 26]. Available from: http://www.worldgastroenterology.org/guidelines/global-guidelines/celiac-disease/celiac-disease-english.
7. Ortega Páez E, Junco Lafuente P, Baca Garcia P, Maldonado Lozano J., Llodra Calvo J.C. Prevalence of dental enamel defects in celiac patients with deciduous dentition: a pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 106:74-78. 2008.
8. Pastore L, Campisi G, Compilato D, Lo Muzio L. Orally based diagnosis of Celiac Disease: Current Perspectives. J Dent Res. Dec; 87(12): 1100-7. 2008.
9. Mantegazza C, Paglia M, Angiero F, Crippa R. Oral manifestations of gastrointestinal diseases in children. Part 4: Coeliac disease. Eur J Paediatr Dent Dec; 17(4):332-34. 2016.
10. Torres PMM, Marçal FF, Dias Ponte E, Carvalho Martins R, Wildson Gurgel Costa F, Sa Roriz Fonteles C, Rodrigues Ribeiro T. Systemic and Oral Aspects in Celiac Disease for Dentistry. J. Dent. Sci. Ther; 1(1): 12-17. 2016.
11. Scully C. Aphthous ulceration. N. Engl J Med; 355: 165-72. 2006.
12. Revised criteria for Diagnosis of Celiac Disease. Working group of European Society of Pediatric Gastroenterology & Nutrition (ESPGHAN). Arch Dis Child; 65(8): 909-11. 1990.
13. Aine L. Dental enamel defects and dental maturity in children and adolescents with coeliac disease. Proc Finn Dent Soc; 82(3): 1–71. 1986.
14. who.int [homepage on the internet]. World Health Organization (WHO): Oral health surveys: basic methods – 5th edition; c2017 [Cited 2017 September 26]. Available from: http://www.who.int/oral_health/publications/9789241548649/en/.
15. Procaccini M, Campisi G, Bufo P, Compilato D, Massaccesi C, Catassi C, Lo Muzio L. Lack of association between celiac disease and dental enamel hypoplasia in a case-control study from an Italian central region. Head Face Med; 3:25. 2007.
16. Costacurta M, Maturo P, Bartolino M, Docimo R. Oral manifestations of coeliac disease-a clinical-statistic study. ORAL &Implantology – Anno III – N. 1/2010.
17. Majorana A, Bardellini E, Ravelli A, Plebani A, Polimeni A, Campus G. Implications of gluten exposure period, CD clinical forms, and HLA typing in the association between celiac disease and dental enamel defects in children. A case–control study. Int J Paediatr Dent; 20:119–24. 2010.
18. Bucci P, Carile F, Sangianantoni A, D’Angio F, Santarelli A, Lo Muzio L. Oral aphthous ulcers and dental enamel defects in children with coeliac disease. Acta Paediatr; 95:203-7. 2006.
19. Trotta L, Biagi F, Bianchi PI, Marchese A, Vattiato C, Balduzzi D, Collesano V, Corazza GR. Dental enamel defects in adult coeliac disease: prevalence and correlation with symptoms and age at diagnosis. Eur J Intern Med. Dec; 24(8): 832-4. 2013.
20. Campisi G, Di Liberto C, Iacono G, Compilato D, Di Prima L, Calvino F, Di Marcos V, Lo Muzio L, Sferrazza C, Scalici C, Craxis A, Caroccio A. Oral Pathology in untreated coeliac disease. Aliment Pharmacol Ther; 26:1529-36. 2007.
21. Bramanti E, Cicciù M, Matacena G, Costa S, Magazzù G. Clinical Evaluation of Specific Oral Manifestations in Pediatric Patients with Ascertained versus Potential Coeliac Disease: A Cross-Sectional Study. Gastroenterol Res Pract. 2014;:934159. 2014.
22. Wierink CD, Van Diermen ED, Aartman IHA, Heymans HSA. Dental enamel defects in children with coeliac disease. Int J Clin Pediatr Dent; 17:163–8. 2007.
23. Priovolou CH, Vanderas AP, Papagiannoulis L. A comparative study on the prevalence of enamel defects and dental caries in children and adolescents with and without coeliac disease. Eur J Paediatr Dent. Jun; 5(2): 102-6. 2004.
24. Avsar A, Kalayci AG. The presence and distribution of dental enamel defects and caries in children with celiac disease.Turk J Pediatr; 50:45- 50. 2008.
25. Aguirre JM, Rodriguez R, Oribe D, Vitoria JC. Dental enamel defects in celiac patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod; 84: 646-50. 1997.
26. Maki M, Aine L, Lipsanen V, Koskimies S. Dental enamel defects in first-degree relatives of coeliac disease patients. Lancet 30; 337(8744): 763-4. 1991.
27. Mariani P, Mazzilli MC, Margutti G, Lionetti P, Triglione P, Petronzelli F, Ferrante E, Bonamico M. Coeliac disease, enamel defects and HLA typing. Acta Paediatr; 83: 1272-5. 1994.
28. Erriu M, Sanna S, Nucaro A, Orrù G, Garau V, Montaldo C. HLA-DQB1 Haplotypes and their Relation to Oral Signs Linked to Celiac Disease Diagnosis. Open Dent J.; 5: 174–78. 2011.
29. Erriu M, Abbate GM, Pili FMG, Novara F, Orrù G, Montaldo C, Piras V, Levrini L. Oral Signs and HLA-DQB1∗02 Haplotypes in the Celiac Paediatric Patient: A Preliminary Study. Autoimmune Dis. 2013; 2013: 389590.Aine L, Mäki M, Collin P, Keyriläinen O. Dental enamel defects in celiac disease. J Oral Pathol Med; 19: 241-5. 1990.
30. Souto-Souza D, da Consolação Soares ME, Rezende VS, de Lacerda Dantas PC, Galvão EL, Falci SGM. Association between developmental defects of enamel and celiac disease: A meta-analysis. Arch Oral Biol. Mar; 87: 180-190. 2018.
31. Kevrekidou A, Kosma I, Arapostathis K, Kotsanos N. Molar Incisor Hypomineralization of Eight- and 14-year-old Children: Prevalence, Severity and Defect Characteristics. Pediatr Dent ; 37(5): 455-61. 2015.
32. Ouda S, Saadah O, El Meligy O, Alaki S. Genetic and dental study of patients with celiac disease. J Clin Pediatr Dent; 35(2):217-24. 2010.
33. Cheng J, Malahias T, Brar P, Minaya MT, Green PH. The Association Between Celiac Disease, Dental Enamel Defects, and Aphthous Ulcers in a United States Cohort. J Clin Gastroenterol. Mar;44(3):191-4. 2010.
34. Dane A, Gürbüz T. Clinical evaluation of specific oral and salivary findings of coeliac disease in eastern Turkish paediatric patients. Eur J Paediatr Dent. Mar;17(1):53-6. 2016.
35. Farmakis E, Puntis JWL, Toumba KJ. Enamel defects in children with coeliac disease. Eur J Paediatr Dent. Sep; 6(3): 129-32. 2005.
36. Krzywicka B, Herman K, Kowalczyk-Zając M, Pytrus T. Celiac Disease and Its Impact on the Oral Health Status – Review of the Literature. Adv Clin Exp Med; 23(5): 675–81. 2014.
37. Mastora A, Vadiakas G, Agouropoulos A, Gartagani-Panagiotopoulou P, Gemou Engesaeth V. Developmental Defects of Enamel In First Permanent Molars Associated With Use Of Asthma Drugs In Preschool Aged Children: A Retrospective Case-Control Study. Eur Arch Paediatr Dent. Apr. 18(2): 105-11. 2017.
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