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Original Research

Open Access

Enhancing the Remineralization Potential of Child Formula Dentifrices: An In Vitro Study

  • Mohammed Nadeem Ahmed Bijle1
  • Lai Pui Tung2
  • Jasmine Wong2
  • Manikandan Ekambaram3
  • Edward CM Lo4
  • Cynthia Kar Yung Yiu1,*,

1Paediatric Dentistry, Faculty of Dentistry, The University of Hong Kong

2Faculty of Dentistry, The University of Hong Kong

3Paediatric Dentistry, Faculty of Dentistry, University of Otago, Dunedin, New Zealand

4Dental Public Health, Faculty of Dentistry, The University of Hong Kong, Hong Kong

DOI: 10.17796/1053-4625-43.5.6 Vol.43,Issue 5,September 2019 pp.337-344

Published: 01 September 2019

*Corresponding Author(s): Cynthia Kar Yung Yiu E-mail: ckyyiu@hkucc.hku.hk

Abstract

Objective(s): The incorporation of Arginine (Arg) in NaF-containing child dentifrice might enhance its remineralizing potential, reducing fluorosis risk with significant anti-caries benefit. The study objective was to examine the remineralizing potential of arginine in child formula dentifrice (600-ppm NaF).Study Design: Primary teeth enamel specimens (n = 10) with artificial caries-like lesion were randomly divided to 4 treatment groups: A: 2% Arg-(600-ppm) NaF; B: 600-ppm NaF; C: 1100-ppm NaF; and D: deionized water subjected to 7-day pH-cycling. The mineral density (MD) of the treated specimens was assessed using microCT. The pre-/post-treated artificial caries-like lesion were acid-etched for enamel fluoride uptake (EFU) evaluation, Ca and P element analysis using ICP-OES, and the inorganic phosphate (PO43-) determination using colorimetric assay. Results: The percentage remineralization of the 2% Arg-NaF and 1100-ppm NaF groups was significantly higher than the 600-ppm NaF group (p<0.001). However, no significant difference in remineralization was observed between the two groups (p>0.05). The EFU, Ca/P ratio, PO43- content of the 2% Arg-NaF group were significantly higher than the 600-ppm NaF group (p<0.01); while no significant difference was found between the 2% Arg-NaF and 1100-ppm NaF groups. Conclusion: Within the limitations of the present study, incorporation of 2% arginine in 600-ppm NaF child formula dentifrice enhanced the remineralization potential of artificial enamel caries, to a level comparable to 1100-ppm NaF adult formula dentifrice.


Keywords

Arginine; Child; Dentifrices; Enamel; Remineralization

Cite and Share

Mohammed Nadeem Ahmed Bijle,Lai Pui Tung,Jasmine Wong,Manikandan Ekambaram,Edward CM Lo,Cynthia Kar Yung Yiu. Enhancing the Remineralization Potential of Child Formula Dentifrices: An In Vitro Study. Journal of Clinical Pediatric Dentistry. 2019. 43(5);337-344.

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