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Type 1 Diabetes Mellitus (Juvenile Diabetes) – A Review for the Pediatric Oral Health Provider
1University of Kentucky, Pediatric Dentist in Jerusalem, Israel
2 Division of Pediatric Endocrinology, Hadassah Medical Organization, Jerusalem, Israel
3 Department of Oral and maxillofacial Diagnostic Sciences, University of Florida, USA
*Corresponding Author(s): Bimstein E E-mail: bimsteine@gmail.com
Objective: To describe the significance of type 1 diabetes mellitus (juvenile diabetes) to the pediatric oral health provider. Relevance: The oral health provider must be aware of type 1 diabetes mellitus (T1DM) characteristics, influence of on oral health, each patient pre-operative diabetic management, symptoms and treatment of hypo and hyper-glycemia, and the clinical implications before, during and after treatment of children with T1DM. Study design: A review of the scientific literature about the T1DM influence on dental development, caries prevalence, gingival and periodontal diseases, wound healing, salivary and taste dysfunction, oral infections, and the factors that must be taken in consideration before, during and after oral treatment of children with T1DM is presented. Conclusion: The increasing prevalence of T1DB in children strongly emphasizes the need for oral health providers to be aware of the complicacy of the treatment aimed to obtain and maintain acceptable blood glucose levels in diabetic children, the effect of diabetes on the oral cavity, the possible serious complications due to hypo- or hyper glycemia before, during and after oral treatments, the effect of stress on blood glucose levels, and the special behavioral interaction between the diabetic child, his/her family and the oral health providers.
Diabetes; Pediatric dentistry; Management
Bimstein E,Zangen D,Abedrahim W,Katz J. Type 1 Diabetes Mellitus (Juvenile Diabetes) – A Review for the Pediatric Oral Health Provider. Journal of Clinical Pediatric Dentistry. 2019. 43(6);417-423.
1. Nirmala SVSG, Saikrishna D. Dental care and treatment of children with diabetes mellitus – an overview. J Pediatr Neonatal Care 4: eISSN: 2373- 4426, 2016.
2. Babu SR, Eisenbarth GS. Juvenile diabetes. Indian J Med Res 136: 179–81, 2012.
3. Hong YHJ, Hassan N, Cheah YK, Jalaludin MY, Kasim ZM. Management of T1DM in children and adolescents in primary care. Malays Fam Physician 31: 18-22, 2017.
4. World Health Organization. Definition, diagnosis and classification of diabetes mellitus and its complications. http://apps.who.int/iris/ bitstream/10665/66040/1/WHO_NCD_NCS_99.2.pdf. Cited October 30, 2018.
5. World Health Organization. Diabetes. http://www.who.int/diabetes/en/. Cited October 21, 2018.
6. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes care 33: s62-s69, 2010.
7. World Health Organization. Global report on Diabetes, part 1 global burden of diabetes. http://apps.who.int/iris/bitstream/handle/10665/204871/9789241565257_eng.pdf;jsessionid=B543D33283A7A4D677889B7D286CA5F3?sequence=1. Cited October 21, 2018.
8. Juvenile Diabetes Research Foundation. http://www.jdrf.org/about/whatis-t1d/facts/. Cited October 21, 2018.
9. Maahs DM, West NA, Lawrence JM, Mayer-Davis EJ. Epidemiology of Type 1 Diabetes. Chapter 1, NIH Public Access. Endocrinol Metab Clin North Am 39: 481–497, 2010.
10. Lancet. Variation and trends in incidence of childhood diabetes in Europe. EURODIAB ACE study group 11:355(9207): 876-6, 2000.
11. Zung A. Blumenfeld O, Shehadeh N, Dally Gottfried O, Tenenbaum Rakover Y, Hershkovitz E, Gillis D, Pinhas-Hmiel O, Hanukoglu A, Rachmiel M, Shalitin S; Israel IDDM Registry study group.. Increase in the incidence of type1 diabetes in Israel following the second Lebanon war. Pediatr Diabetes 13: 326-33, 2012.
12. Green A, Patterson GA. Trends in incidence of childhood-onset diabetes in Europe 1989-1998. Diabetologia 44: B3-B8, 2001
13. López del Valle, L. M., Ocasio-López C (2011) Comparing the oral health status of diabetic and non-diabetic children from Puerto Rico: a case-control pilot study. P R Health Sci J 30: 123-7, 2011.
14. Ziegler AG, Rewers M, Simell O, Simell T, Lempainen J, Steck A, Winkler C, Ilonen J, Veijola R, Knip M, Bonifacio E, Eisenbarth GS. Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA 309: 2473-9, 2013.
15. Paschou SA, Papadopoulou-Marketou N, Chrousos GP, Kanaka-Gantenbein C. On type 1 diabetes mellitus pathogenesis. Endocr Connect 7: R38-R46, 2018.
16. Hober D, F. Sane (2010) Enteroviral pathogenesis of type 1 diabetes. Discov Med 10: 151-60, 2010.
17. Oikarinen S, Tauriainen D, Hober B. Lucas A, Vazeou, Sioofy-Khojine A, Bozas E, Muir, HP. Honkanen H, Ilonen J, Knip M, Keskinen P, Saha MT, Huhtala H, Stanway G, Bartsocas C, Ludvigsson J, Taylor K, Hyöty H, VirDiab Study Group. Virus antibody survey in different European populations indicates risk association between coxsackievirus B1 and type 1 diabetes. Diabetes 63: 655-62, 2014.
18. Virtanen, S. M. & M. Knip (2003) Nutritional risk predictors of beta cell autoimmunity and type 1 diabetes at a young age. Am J Clin Nutr 78: 1053-67, 2013.
19. Schmidt F, Kapellen TM, Wiegand S, Herbst A, Wolf J, Frohlic-Reiterer EE, Rabl W. Rohrer T, Holl RW. Diabetes mellitus in children and adolescents with genetic syndromes. Exp. Clin Endocrinol Diabetes 1120: 579-85, 2012.
20. American Diabetes Association. Stress. http://www.diabetes.org/living-with-diabetes/complications/mental-health/stress.html Cited October 21, 2018.
21. Mayo Clinic. Type 1 diabetes in children. https://www.mayoclinic.org/diseases-conditions/type-1-diabetes-in-children/symptoms-causes/syc-20355306. Cited October 21, 2018.
22. Shyu CS, Lin HK, Lin CH, Fu LS. Prevalence of attention deficit /hyperactivity disorder in patients with pediatric allergic disorders: a nationwide, population-based study. J Microbiol Immunol Infect 45: 237-42, 2012.
23. Chen H, Lee YJ, Yen GC, Lin HC. Association of attention-deficit /hyperactivity disorder with diabetes: a population based study. Pediatr Res 73: 492-6, 2013.
24. Tsai JD, Chang SN, Mou CH, Sung FC, Lue KH. Association between atopic diseases and attention-deficit/hyperactivity disorder I childhood: a population-based case-control-study. An Epidemiol23: 185-8, 2013.
25. Nigg J. Attention-deficit/hyperactivity disorder and adverse health outcomes. Clin Psycol Review 33: 215-28, 2013.
26. Centers for Disease Control and Prevention. Attention-Deficit / Hyperactivity Disorder (ADHD). Symptoms and diagnosis. https://www.cdc.gov/ncbddd/adhd/diagnosis.html. Cited October 21, 2018.
27. Cameron FJ, Scratch SE, Nadebaum C, Northam EA, Koves I, Jennings J, Finnet k, Neil JJ, Wellard RM, Mackay M, Inder TE. Neurological consequences of diabetic ketoacidosis at initial presentation of type 1 diabetes in a prospective cohort study of children. Diabetes care 37: 1554-62, 2014.
28. DiMeglio LA, Evans-Molina C, Oram RA Type 1 diabetes. Lancet 391: 2449-2462, 2018.
29. Haslacher H, Fallman H, Waldhausl C, Hartmann E, Wagner OF, Waldhausl W. Type 1 diabetes care: improvement by standardization in a diabetes rehabilitation clinic. An observational report. PLoS One 12: https://doi.org/10.1371/journal.pone.0194135, 2018. Cited October 23, 2018.
30. Almusawi MA, Gosadi I, Abidia R, Almasawi M, Khan HA. Potential risk factors for dental caries in Type 2 diabetic patients. Int J Dent Hyg 16: 467-75, 2018
31. Nunchievici IM, Lăcătuşu S. Cariogenic risk assessment in a group of diabetic patients. Rev Med Chir Soc Med Nat Iasi 113: 241-5, 2009.
32. Siudikiene JV, Machiulskiene B, Nyvad J, Tenovuo J, Nedzelskiene I. (2006) Dental caries and salivary status in children with type 1 diabetes mellitus, related to the metabolic control of the disease. Eur J Oral Sci 114: 8-14, 2006.
33. Bolgül BS, Celenk S, Ayna BE, F. Atakul F, Uysal E. Evaluation of caries risk factors and effects of a fluoride-releasing adhesive material in children with insulin-dependent diabetes mellitus (IDDM): initial first-year results. Acta Odontol Scand 62:289-92, 2004.
34. Siudikeine J, Machiulkiene V, Nvvad B, Tenovuo J, Nedzelkiene I. Dental caries increments and related factors in children with type 1 diabetes mellitus. Epub 42: 354-62, 2008.
35. Lal SB, Cheng S. Kaplan, Softness B, Greenberg E, Goland RS, Lalla E, Lamster IB. Gingival bleeding in 6- to 13-year-old children with diabetes mellitus. Pediatr Dent 29: 426-30, 2007.
36. Orbak RS, Simsek S, Orbak Z, Kavrut F, Colak M (2008) The influence of type-1 diabetes mellitus on dentition and oral health in children and adolescents. Yonsei Med J 49: 357-65, 2008.
37. Moreira AR, Passos IA, Sampaio FC, Soares MS, Oliveira RJ. Flow rate, pH and calcium concentration of saliva of children and adolescents with type 1 diabetes mellitus. Braz J Med Biol Res 42: 707-11, 2009.
38. López ME, Colloca ME, Páez RG, Schallmach JN, Koss MA, Chervonagura A. Salivary characteristics of diabetic children. Braz Dent J 14: 26-31, 2003.
39. Zalewska A, Knaś M, Kuźmiuk A, Waszkiewicz N, Niczyporuk M, Waszkiel D, Zwierz K. Salivary innate defense system in type 1 diabetes mellitus in children with mixed and permanent dentition. Acta Odontol Scand 71: 1493-500, 2013.
40. Lalla E, Cheng B, Lal S, Kaplan S, Softness B, Greenberg E, Goland RS, Lamster IB. Diabetes mellitus promotes periodontal destruction in children. J Clin Periodontol 34: 294-8, 2007.
41. Dakovic D, Pavlovic MD. Periodontal disease in children and adolescents with type 1 diabetes in Serbia. J Periodontol 79: 987-92, 2008.
42. Xavier AC, Silva IN, Costa FEO, Corrêa DS. Periodontal status in children and adolescents with type 1 diabetes mellitus]. Arq Bras Endocrinol Metabol 53: 348-54, 2009.
43. Lalla E, Cheng B, Lal S, Tucker S, Greenberg E, Goland R, Lamster IB. Periodontal changes in children and adolescents with diabetes: a case-control study. Diabetes Care 29: 295-9, 2006.
44. Campus G, Salem A, Uzzau S, Baldoni E, Tonolo G. Diabetes and periodontal disease: a case-control study. J Periodontol 76, 418-25, 2005.
45. Arangannal Santoshkumari, Krishnan P, Nichani M, Krishnan M, Chamarthi V. Detection of putative periodontopathic bacteria in type 1 diabetic and healthy children: a comparative study. Indian J Dent Res 24: 342-6, 2013.
46. Siudikiene J. Maciulskiene V, Dobrovolskiene R, Nedzelskiene I. Oral hygiene in children with type I diabetes mellitus. Stomatologija 7: 24-7, 2005.
47. PreshawP, Alba MAL, Herrera D, Jepsen S, Konstantinidis A, Makrilakis K, Taylor R. Periodontitis and diabetes: a two-way relationship. Diabetologia 55: 21-31, 2012.
48. Ryan ME, Usman A, Ramamurthy NS, Golub LM, Greenwald RA. Excessive matrix metalloproteinase activity in diabetes: inhibition by tetracycline analogues with zinc reactivity. Curr Med Chem 8: 305-16, 2001.
49. Grover HS, Luthra S Molecular mechanisms involved in the bidirectional relationship between diabetes mellitus and periodontal disease. J Indian Soc Periodontol 17: 292-301, 2013
50. Ryan ME, Ramamurthy NS, Sorsa T, & L. M. Golub LM. MMP-mediated events in diabetes. Ann N Y Acad Sci 878: 311-34, 1999.
51. Slade GD, Offenbacher S, Beck JD, Heiss G, Pankow JS. Acute-phase inflammatory response to periodontal disease in the US population. J Dent Res 79: 49-57, 2000.
52. Stanko P, Izakovicova Holla L. Bidirectional association between diabetes mellitus and inflammatory periodontal disease. A review. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 158: 35-8, 2014.
53. Adler P, Wegner H, Bohatka L. Influence of age and duration of diabetes on dental development in diabetic children. J Dent Res 52: 535-7, 1973.
54. Bohátka L, Wegner H, Adler P. Parameters of the mixed dentition in diabetic children. J Dent Res 52: 131-5, 1973.
55. Ziskin DE, Siegel EH, Loughlin WC. Diabetes in relation to certain oral and systemic problems. Part I: Clinical study of dental caries, tooth eruption, gingival inflammation, growth phenomena, and related observations in juveniles. https://doi.org/10.1177/00220345440230050401, 1944. Cited October 23, 2018
56. Luan X, Ito Y, Holliday S, Walker C, Daniel J, Galang TM. Fukui T, Yamane A, Begole E, Evans C, T. G. Diekwisch TG. Extracellular matrix-mediated tissue remodeling following axial movement of teeth. J Histochem Cytochem 55: 127-40, 2007.
57. Symons A, Weerakoon LA, Marks SC. Growth hormone receptor and insulin-like growth factor-I immunoreactivity in osteoclast-like cells during tooth eruption in the toothless (osteopetrotic) rat following treatment with colony-stimulating factor-1. Crit Rev Eukaryot Gene Expr 13: 195-204, 2003.
58. Hartsfield JK. Premature exfoliation of teeth in childhood and adolescence. Adv Pediatr 41: 453-70, 1994.
59. Abiko Y, Selimovic D. The mechanism of protracted wound healing on oral mucosa in diabetes. Review. Bosn J Basic Med Sci 10: 186-91, 2010.
60. Seele RG. The chemical senses and diabetes mellitus. In: Getchell TV, Doty RL, Bartoshik LM, Snow Jr JB (Eds.). Smell and taste in health and disease. New York, Raven Press; 829-843, 1991
61. Leite RS, Marlow NM, Fernandes JK. Oral health and type 2 diabetes. Am J Med Sci 345: 271-3, 2013.
62. Moore PA, Guggenheimer J, Etzel KR, Wevant RJ, Orchard T. Type 1 diabetes mellitus, xerostomia, and salivary flow rates. Oral surg, Oral Med Oral Pathol Radiol Endod 2001: 281-91, 2001.
63. Lughetti L, Marino R, Bertolani MF, Bernasconi S. Oral health in children with IDDM—a review. J Pediatr Endocrinol Metab 12: 603-10, 1991
64. Carneiro VL, Fraiz VC, Ferreira F de M, Pintarelli TP, Oliveira AC, Boguszewski MC. The influence of glycemic control on the oral health of children and adolescents with diabetes mellitus type 1. Arch Endocrinol Metab 59: 535-40, 2015.
65. Kao CH, Tsai SC, Sun SS. Scintigraphic evidence of poor salivary function in type 2 diabetes. Diabetes Care 24: 952-53, 2001.
66. Murrah V, Crosson JT, Sauk JJ. Parotid gland basement membrane variation in diabetes mellitus. J Oral Pathol 14: 236-46, 1985.
67. Chávez EM, Borrell LN, Taylor GW, Ship JA. A longitudinal analysis of salivary flow in control subjects and older adults with type 2 diabetes. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91: 166-73, 2001.
68. Olczak-Kowalczyk D, Pyrżak B, Dąbkowska M, Pańczyk-Tomaszewska M, Miszkurka G, Rogozińska I, Swoboda-Kopeć E, Gozdowski D, Kalińska A, Piróg A, Mizerska-Wasiak M, Roszkowska-Blaim M. Candida spp. and gingivitis in children with nephrotic syndrome or type 1 diabetes. BMC Oral Health 15: 57 2015.
69. Carneiro VL, Fraiz FC, Ferreira FEM, Pintarelli TP, Oliveira AC, Boguszewski MC (2015) The influence of glycemic control on the oral health of children and adolescents with diabetes mellitus type 1. Arch Endocrinol Metab 59: 535-40, 2015.
70. Guggenheimer J, Moore PA, Rossie K, Myers D, Mongelluzo MB, Block MH, Weyant R, Orchard T. Insulin-dependent diabetes mellitus and oral soft tissue pathologies, part I: prevalence and characteristics of non-candidal lesions. Oral Surg Oral Med Oral PatholOral Radiol Endod 89: 563-9, 2000.
71. Nirmala SV, Lalitha V, Sivakumar N, Kumar KK, Srikanth M. Mucormycosis associated with juvenile periodontitis. J Indian Soci of Pedo and Prev Dent 29: s87-s91, 2011.
72. Belazi M, Velegraki A, Fleva A, Gidarakou I, Papanaum L, Baka D, Daniilidou N, Karamitsos D. Candidal overgrowth in diabetic patients: potential predisposing factors. Mycoses 48: 192-6, 2005.
73. Mohammadi F, Javaheri MR, Nekoeian S, Dehghan P. Identification of Candida species in the oral cavity of diabetic patients. Curr Med Mycol 2: 1-7, 2016.
74. Willis AM, Coulter WA, Fulton CR, Hayes JR, Bell PM, Lamey PJ: Oral candidal carriage and infection in insulin-treated diabetic patients. Diabet Med 16: 675-9, 1999.
75. Zeragell DJ. Fungal infections of the oral cavity. Otolaryngol Clin North Am 26: 1069-89, 1993. 76. Huan, TT, Tseng FY, Liu TC, Hsu CJ, Chen YS. Deep neck infection in diabetic patients: comparison of clinical picture and outcomes with nondiabetic patients. Otolaryngol Head Neck Surg 132: 943-7, 2005.
77. Rao DD, Desai A, Kulkarni RD, Gopalkrishnan K, Rao CB. Comparison of maxillofacial space infection in diabetic and nondiabetic patients. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 110: e7-e12, 2010.
78. Lohan A, Morawska A, Mitchell A. A systematic review of parenting interventions for parents of children with type 1 diabetes. Child Care Health Dev 41: 803-17, 2015.
79. Lohan A, Morawska A, Mitchel A. Associations between parental factors and child-management-related behaviors. J Dev Behav Pediatr 38: 330-8, 2017.
80. Sayed MH, Hegazi MA, Abdulwahed K, Moussa K, El-Deek BS, Gabel H, Ragheb R. Risk factors and predictors of uncontrolled hyperglycemia and diabetic ketoacidosis in children and adolescents wit type 1 diabetes mellitus in Jeddah, western Saudi Arabia. J Diabetes 9: 190-9, 2017.
81. ReiterJ, Wexler ID, Shehadeh N, Tzur A, Zangen A. Type 1 diabetes and prolonged fasting. Diabetes Med 24: 436-9, 2007.
82. Herbert LJ, Clary L, Owen V, Monaghan M, Alvarez V, Streisand R. Relations among school/daycare functioning, fear of hypoglycaemia and quality of life in parents of young children with type 1 diabetes. J Clin Nurs 24: 1199-209, 2015.
83. Driscoll KA, Raymond J, Naranjo D, Patton SR. Fear of hypoglycemia I children and adolescents and their parents in Type 1 diabetes. Curr Diab Rep 16: 77, 2016.
84. Oyer DS. The science of hypoglycemia in patients with diabetes. Current Diabetes Reviews 9: 195-208, 2013.
85. Martin-Nemeth P, Quin L, Penckofer S, Park C. Hofer V, Brke L. Fear of hypoglycemia: influence of glycemic variability and self-management behavior in adults with type 1 diabetes. J Diabetes Complications 31: 735-41, 2017.
86. Plummer MP, Finnis ME, Phillips LK, Kar P, Bihari A, Biradar V, Moodie S, Horowitz M, Shaw JE, Deane AM. Stress induced hyperglycemia and the subsequent risk of Type 2 diabetes in survivors of critical illness. plos.org/plosone/article?id=10.1371/journal.pone.0165923, cited, 2018.
87. Juvenile Diabetes Research Foundation. Type 1 diabetes high blood sugar symptoms. http://www.jdrf.org/t1d-resources/symptoms/high-bloodsugar/ cited October 30, 2018.
88. Amitai Y, Zylber-Katz E, Avital A, Zangen D, Noviski N. Serum lidocaine concentrations in children during bronchoscopy with topical anesthesia. Chest 98: 1370-3, 1990
89. Hills-Smith. H, Schuman NJ. Antibiotic therapy in pediatric dentistry II. Treatment of oral infection and management of systemic disease. Ped Dent 5: 45-50, 1983.
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