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Original Research

Open Access

Genetic Polymorphisms in ACTN3 Contribute to the Etiology of Bruxism in Children

  • Calvano Küchler E1,*,
  • Arid J2
  • Palinkas M3
  • Ayumi Omori M2
  • de Lara RM1
  • Napolitano Gonçalves LM3
  • Hallak Regalo SC3
  • Paes Torres Mantovani C2
  • Rezende Vieira A4
  • Diaz-Serrano K2

1Health Sciences, Positivo University. Rua Professor Pedro Viriato Parigot de Souza 5300 – Campo Comprido, Curitiba, PR, Brazil

2Department of Pediatric Dentistry, University of São Paulo–School of Dentistry of Ribeirão Preto, Ribeirão Preto, São Paulo, Brazil

3Department of Morphology, Fisiology, and Basic Patology, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto- Brazil

4Department of Oral Biology, University of Pittsburgh, Pittsburgh, PA USA

DOI: 10.17796/1053-4625-44.3.8 Vol.44,Issue 3,May 2020 pp.180-184

Published: 01 May 2020

*Corresponding Author(s): Calvano Küchler E E-mail: erikacalvano@gmail.com

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Abstract

Objective: Bruxism is a condition defined as a masticatory muscle activity with an unexplored genetic background. The aim of this study was to evaluate the association between genetic polymorphisms in ACTN3 and bruxism. Study design: A total of 151 biological-unrelated children, aged 7–12 years were included in a case control ratio of 1:1.5. The data collection was performed during interview and clinical examination. Saliva samples were collected from all children and 3 genetic polymorphisms in the ACTN3 (rs678397, rs1671064 and rs1815739) were selected for genotyping using real time PCR. Pearson chisquare calculation was used to assess Hardy-Weinberg equilibrium and to evaluate the association between genotypes and alleles frequencies for each genetic polymorphism in the co-dominant and recessive models. An alpha of 5% was used. Results: The genetic polymorphisms rs678397, rs1671064 and rs1815739 were associated with bruxism in the co-dominate model and in the recessive model (p<0.05). Allele distribution was also associated with bruxism for the polymorphisms rs678397 and rs1671064 (p<0.05). Conclusion: The genetic polymorphisms rs678397, rs1671064 and rs1815739 in ACTN3 are associated with bruxism and can contribute to the etiology of this condition in children.


Keywords

Genes; Polymorphism; Children; Bruxism; Muscle and ACTN3

Cite and Share

Calvano Küchler E,Arid J,Palinkas M,Ayumi Omori M,de Lara RM,Napolitano Gonçalves LM,Hallak Regalo SC,Paes Torres Mantovani C,Rezende Vieira A,Diaz-Serrano K. Genetic Polymorphisms in ACTN3 Contribute to the Etiology of Bruxism in Children. Journal of Clinical Pediatric Dentistry. 2020. 44(3);180-184.

URL:

https://www.jocpd.com/articles/10.17796/1053-4625-44.3.8

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