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Original Research

Open Access

Enhanced Fluoride Bioavailability with Incorporation of Arginine in Child Dentifrices

  • Mohammed Nadeem Bijle1
  • James Tsoi2
  • Manikandan Ekambaram3
  • Edward C M Lo4
  • Clifton M Carey5
  • Cynthia Kar Yung Yiu1,*

1Paediatric Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong

2Dental Materials, Faculty of Dentistry, The University of Hong Kong, Hong Kong

3Paediatric Dentistry, Faculty of Dentistry, University of Otago, Dunedin, New Zealand

4Dental Public Health, Faculty of Dentistry, The University of Hong Kong, Hong Kong

5Craniofacial Biology, School of Dental Medicine, University of Colorado, US

6Paediatric Dentistry, Faculty of Dentistry, The University of Hong Kong, Hong Kong

DOI: 10.17796/1053-4625-44.5.7 Vol.44,Issue 5,September 2020 pp.332-341

Published: 01 September 2020

*Corresponding Author(s): Cynthia Kar Yung Yiu E-mail: ckyyiu@hku.hk

Abstract

Objective(s): To: 1) examine the fluoride concentrations in commercial child formula dentifrices (CFD)s; and 2) investigate the effect of arginine incorporation in CFDs on fluoride bioavailability. Study Design: Five commercial CFDs were examined for fluoride concentrations. Total, total soluble, and insoluble fluorides in CFDs were determined by the modified Taves acid-diffusion method (TAD). Ionic F and MFP were estimated by modified direct method with standard addition technique. L-arginine (L-Arg)/Larginine monohydrochloride (L-Arg.HCl) were incorporated at 2% w/w in the commercial CFDs. The pH of the toothpaste slurries, buffer capacity of the added Arg, potentially available fluorides (PAF) and 1-min PAF by TAD were determined. Results: The CFDs had 4 to 32% of insoluble fluorides. Addition of L-Arg/ L-Arg.HCl significantly improved the fluoride bioavailability in CFDs (p<0.05). Incorporation of L-Arg significantly increased the pH of toothpaste slurries (p<0.05); while L-Arg.HCl decreased the pH. Principal component analysis showed that L-Arg.HCl decreased the pH of toothpaste slurries due to the presence of Cl in the form of HCl; whereas the inherent elements/molecules (Na/P/Pi/F) remain distinct with unidentified influence on the variables. Conclusion(s): The CFDs containing NaF only have higher concentrations of bioavailable fluoride. Incorporating arginine (L-arginine or L-arginine monohydrochloride) at 2% w/w improves fluoride bioavailability of the child formula dentifrices.


Keywords

Arginine; Bioavailability; Child; Dentifrices; Fluorides

Cite and Share

Mohammed Nadeem Bijle,James Tsoi,Manikandan Ekambaram,Edward C M Lo,Clifton M Carey,Cynthia Kar Yung Yiu. Enhanced Fluoride Bioavailability with Incorporation of Arginine in Child Dentifrices. Journal of Clinical Pediatric Dentistry. 2020. 44(5);332-341.

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