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Open AccessSerum and Saliva 25(OH)D Levels in Relation to Dental Caries in Young Children
Serum and Saliva 25(OH)D Levels in Relation to Dental Caries in Young Children
- Alaa Sabah Hussein1,*,
- Manal Mohamed Almoudi1
- Mohamed Ibrahim Abu-Hassan2
- Robert J Schroth3,4
- Bahruddin Saripudin5
- Mohd Shawal Firdaus Mohamad6
1Centre of Paediatric Dentistry and Orthodontics Studies, Faculty of Dentistry, Universiti Teknologi MARA, Selangor, Malaysia
2Centre of Restorative Dentistry Studies, Faculty of Dentistry, Universiti Teknologi MARA, Selangor, Malaysia
3Department of Preventive Dental Science, College of Dentistry, Faculty of Health Sciences, University of Manitoba, Canada
4Department of Paediatrics & Child Health, College of Medicine, Faculty of Health Sciences, University of Manitoba, Canada
5Department of Paediatric Dentistry, Hospital Tengku Ampuan Rahimah, Selangor, Malaysia
6Centre of Oral and Maxillofacial Surgery Studies, Universiti Teknologi MARA, Selangor, Malaysia
*Corresponding Author(s): Alaa Sabah Hussein E-mail: dr_alaasabah@yahoo.com alaa@uitm.edu.my
Abstract
Objective: Several studies have reported that low levels of vitamin D (25(OH)D) are associated with an increased risk of dental caries and that optimal levels may offer protection This study aimed to assess the relationship between serum and saliva 25(OH)D levels and caries among young children. Study design: A total of 120 healthy children were recruited; 93 with caries and 27 caries-free. Dental caries status was evaluated using decayed, missing and filled in primary teeth (dmft) index. Blood and unstimulated whole saliva samples were collected. Laboratory analysis was performed using Enzyme-Linked Immunosorbent Assay Kit. Data were analyzed with descriptive statistics, bivariate and Spearman’s rank correlation analysis. Results: There were no significant associations between serum and saliva 25(OH)D levels and caries status (P > 0.05). Levels of 25(OH)D in serum were significantly higher than levels found in saliva (P < 0.05), and a correlation between serum and saliva 25(OH)D levels was observed (P < 0.05). Conclusions: The association between serum and saliva 25(OH)D and dental caries in young children was inconclusive. However, a positive and significant correlation was observed between serum and saliva 25(OH)D levels. Further studies are warranted to investigate the definite relation between 25(OH)D levels and dental caries and using saliva 25(OH)D as a non-invasive alternative method over blood samples.
Keywords
Caries; Children; Saliva; Vitamin D; 25(OH)D
Cite and Share
Alaa Sabah Hussein,Manal Mohamed Almoudi,Mohamed Ibrahim Abu-Hassan,Robert J Schroth,Bahruddin Saripudin,Mohd Shawal Firdaus Mohamad. Serum and Saliva 25(OH)D Levels in Relation to Dental Caries in Young Children. Journal of Clinical Pediatric Dentistry. 2021. 45(6);414-420.
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