Article Data

  • Views 1713
  • Dowloads 438

Case Reports

Open Access

A 15-year Follow-Up of a Gingivectomy Procedure for Idiopathic Gingival Fibromatosis: A Case Report and Literature Review

  • Keisuke Seki 1,2,*,
  • Shuichi Sato3,4

1Department of Comprehensive Dentistry and Clinical Education, Nihon University School of Dentistry, Tokyo, Japan

2Division of Dental Education, Dental Research Center, Nihon University School of Dentistry, Tokyo, Japan

3Department of Periodontology, Nihon University School of Dentistry, Tokyo, Japan

4Division of Advanced Dental Treatment, Dental Research Center, Nihon University School of Dentistry, Tokyo, Japan

DOI: 10.17796/1053-4625-46.2.5 Vol.46,Issue 2,March 2022 pp.119-124

Published: 01 March 2022

*Corresponding Author(s): Keisuke Seki E-mail: seki.keisuke@nihon-u.ac.jp

Abstract

Few long-term reports exist concerning the treatment of idiopathic gingival fibromatosis, which is a rare autosomal dominant genetic disorder associated with non-inflammatory, benign, and chronic fibrous gingival proliferation and which causes serious esthetic problems. The aim of this study was to report a case of idiopathic gingival fibromatosis treated with a gingivectomy using an inverse bevel flap method and comprehensively followed up for 15 years. A female patient visited a pediatric dentist at 7 years of age; however, a gingivectomy was not performed until the age of 20 years because of an uncertain prognosis. Now, more than 15 years after the gingivectomy, there has been no significant recurrence and the disease is well managed. Treatment by gingivectomy with an inverse bevel flap approach may provide long-term prevention of recurrence of gingival fibromatosis into adulthood. The aim of this study was to obtain new findings on the pathogenesis and prognosis of this rare disease and to review the case reports previously published.

Keywords

Idiopathic gingival fibromatosis; Inverse bevel flap procedure; Gingivectomy; Long-term followup; Recurrence

Cite and Share

Keisuke Seki ,Shuichi Sato. A 15-year Follow-Up of a Gingivectomy Procedure for Idiopathic Gingival Fibromatosis: A Case Report and Literature Review. Journal of Clinical Pediatric Dentistry. 2022. 46(2);119-124.

References

1. Hart TC, Zhang Y, Gorry MC, et al. A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1. Am J Hum Genet 70(4): 943-54, 2002.

2. Coletta RD, Graner E. Hereditary gingival fibromatosis: a systematic review. J Periodontol 77(5): 753-64, 2006.

3. Pehlivan D, Abe S, Ozturk S, et al. Cytogenetic analysis and examination of SOS1 gene mutation in a Turkish family with hereditary gingival fibromatosis. J Hard Tissue Biol 18(3): 131-4, 2009.

4. Baptista IP. Hereditary gingival fibromatosis: a case report. J Clin Periodontol 29(9): 871-4, 2002.

5. Emerson TG. Hereditary gingival hyperplasia: a family pedigree of four generations. Oral Surg Oral Med Oral Pathol 19: 1-9, 1965.

6. Ramnarayan BK, Sowmya K, Rema J. Management of idiopathic gingival fibromatosis: report of a case and literature review. Pediatr Dent 33(5): 431-6, 2011.

7. Shashi V, Pallos D, Pettenati MJ, et al. Genetic heterogeneity of gingival fibromatosis on chromosome 2p. J Med Genet 36(9): 683-6, 1999.

8. Xiao S, Wang X, Qu B, et al. Refinement of the locus for autosomal dominant hereditary gingival fibromatosis (GINGF) to a 3.8-cM region on 2p21. Genomics 68(3): 247-52, 2000.

9. Wright HJ, Chapple IL, Matthews JB. TGF-beta isoforms and TGF-beta receptors in drug-induced and hereditary gingival overgrowth. J Oral Pathol Med 30(5): 281-9, 2001.

10. Boutiou E, Ziogas IA, Giannis D, Doufexi AE. Hereditary gingival fibromatosis in children: a systematic review of the literature. Clin Oral Investig 25(6): 3599-3607, 2021. doi: 10.1007/s00784-020-03682-x.

11. Newman PS. The effects of the inverse bevel flap procedure on gingival contour and plaque accumulation. J Clin Periodontol 11(6): 361-6, 1984.

12. Seki K, Sato S, Asano Y, Akutagawa H, Ito K. Improved pathologic teeth migration following gingivectomy in a case with idiopathic gingival fibromatosis. Quintessence Int 41(7): 543-5, 2010.

13. Camilotti RS, Jasper J, Ferreira TB, Antonini F, Poli VD, Pagnoncelli RM. Resection of gingival fibromatosis with high-power laser. J Dent Child 82(1): 47-52, 2015.

14. Kamolmatyakul S, Kietthubthew S, Anusaksathien O. Long-term management of an idiopathic gingival fibromatosis patient with the primary dentition. Pediatr Dent 23(6): 508-13, 2001.

15. Kavvadia K, Pepelassi E, Alexandridis C, Arkadopoulou A, Polyzois G, Tossios K. Gingival fibromatosis and significant tooth eruption delay in an 11-year-old male: a 30-month follow-up. Int J Paediatr Dent 15(4): 294-302, 2005.

16. Shetty AK, Shah HJ, Patil MA, Jhota KN. Idiopathic gingival enlargement and its management. J Indian Soc Periodontol 14(4): 263-5, 2010.

17. Saini A, Singh M, Singh SC. A rare case of isolated idiopathic gingival fibromatosis. Indian J Dent Res 24(1): 139-41, 2013.

18. Gita B, Chandrasekaran S, Manoharan P, Dembla G. Idiopathic gingival fibromatosis associated with progressive hearing loss: a nonfamilial variant of Jones syndrome. Contemp Clin Dent 5(2): 260-3, 2014.

19. Pol DG, Lobo TM, Pol SD. Idiopathic gingival fibromatosis with asymmetrical presentation and electrosurgical management. J Indian Soc Periodontol 20(1): 98-102, 2016.

20. Ramakrishnan T, Kaur M. Multispeciality approach in the management of patient with hereditary gingival fibromatosis: 1-year followup: a case report. Int J Dent 2010: 575979, 2010. doi: 10.1155/2010/575979.

21. Doufexi A, Mina M, Ioannidou E. Gingival overgrowth in children: epidemiology, pathogenesis, and complications. A literature review. J Periodontol 76(1): 3-10, 2005.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

PubMed (MEDLINE) PubMed comprises more than 35 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full text content from PubMed Central and publisher web sites.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Scopus: CiteScore 2.0 (2022) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Submission Turnaround Time

Conferences

Top