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Open Access

Evidence of Association between MTRR and TNF-α Gene Polymorphisms and Oral Health Related Quality of Life in Children with Anterior Open Bite

  • Ellen Cardoso Teixeira1
  • Bruno Moreira das Neves2
  • Thuanny Castilho1
  • Thayane Silva Ramos3
  • Adriele Flaviana3
  • Julia Carelli4,5
  • Erika Calvano Kuchler4,5
  • Fabiana Nunes Germano6
  • Lívia Azeredo Alves Antunes1,7
  • Leonardo Santos Antunes1,7

1Postgraduate Program in Dentistry of Niterói, School of Dentistry, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil

2Postgraduate Program in Dentistry of Nova Friburgo, School of Dentistry, Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil

3Clinical Research Unit, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil

4School of Health Science, Positivo University, Curitiba, Paraná, Brazil

5School of Health Science, Federal University of Paraná, Curitiba, Paraná, Brazil

6Postgraduate Program in Dentistry of Nova Friburgo, School of Dentistry, Fluminense Federal University. Department of Basic Science, Fluminense Federal University, Nova Friburgo, RJ, Brazil

7Postgraduate Program in Dentistry of Nova Friburgo, School of Dentistry, Fluminense Federal University. Department of Specific Formation of the Health Institute of Nova Friburgo (FFE-ISNF) Fluminense Federal University, Nova Friburgo, Rio de Janeiro, Brazil

DOI: 10.17796/1053-4625-46.3.12 Vol.46,Issue 3,May 2022 pp.249-256

Published: 01 May 2022

Abstract

Genetic polymorphisms could explain the inter-individual differences in the oral health-related quality of life (OHRQoL) of children with anterior open bite (AOB). Objective: To assess the impact of AOB on OHRQoL in children and to evaluate whether MTR (rs1805087), MTRR (rs1801394), TGFβ1 (rs1800469) and TNF-α (rs1799964, rs1799724 and rs1800629) genes are potential biomarkers for OHRQoL in children with AOB. Study design: A cross-sectional study was performed with 173 children aged between 2–6 years. The Brazilian version of Early Childhood Oral Health Impact Scale (ECOHIS) was applied. Genetic polymorphisms were analyzed using real-time PCR. Mann-Whitney U-test and Chi-square were used. Results: The overall mean ECOHIS scores were 5.49 (SD= 5.72) and 3.45 (SD = 4.49) (p < 0.01) in the AOB and control groups, respectively. Children with the CC genotype of TNF-α (rs1799724) had a significantly higher psychological QoL level. The MTRR AA genotype group showed a lower QoL level in the child subscale (p = 0.006), function (p = 0.017), and psychological (p = 0.006) domains. There was no significant difference between OHRQoL and the genetic polymorphisms in MTR and TGFβ1. Conclusions: Genetic polymorphisms in TNF-α and MTRR are associated with the impact on the OHRQoL in children with AOB.

Keywords

Open bite; Malocclusion; Quality of life; Genetic polymorphism

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Ellen Cardoso Teixeira,Bruno Moreira das Neves,Thuanny Castilho,Thayane Silva Ramos,Adriele Flaviana,Julia Carelli,Erika Calvano Kuchler,Fabiana Nunes Germano,Lívia Azeredo Alves Antunes,Leonardo Santos Antunes. Evidence of Association between MTRR and TNF-α Gene Polymorphisms and Oral Health Related Quality of Life in Children with Anterior Open Bite. Journal of Clinical Pediatric Dentistry. 2022. 46(3);249-256.

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