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Orthodontic Consideration in Patients with Beta-Thalassemia Major: Case Report and Literature Review

  • Shmuel Einy1
  • Hagai Hazan-Molina2
  • Ayelet Ben-Barak3
  • Dror Aizenbud4,*,

1Orthodontic and Craniofacial Department, School of Graduate Dentistry, Rambam Health Care Campus, Haifa, Israel

2Orthodontic and Craniofacial Department, School of Graduate Dentistry, Rambam Health Care Campus,, Bruce and Ruth Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel

3Bruce and Ruth Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Pediatric Hemato-Oncology Department, Rambam Rambam Health Care Campus, Haifa, Israel

4Orthodontic and Craniofacial Department, School of Graduate Dentistry, Rambam Health Care Campus, Bruce and Ruth Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel

DOI: 10.17796/1053-4628-40.3.241 Vol.40,Issue 3,May 2016 pp.241-246

Published: 01 May 2016

*Corresponding Author(s): Dror Aizenbud E-mail:


Objective: Beta Thalassemia (βT) patients present a unique facial appearance and specific craniofacial, jaw and dental patterns. Although this anomaly often requires orthodontic management, βT patients have received scant attention in the orthodontic and dental literature over the past 50 years. The aim of this article is to review the characteristic craniofacial and dental manifestation pattern of βT patients and to emphasize their preferred orthodontic management protocol by presenting a βT orthodontic treated patient. Case report: A 10 year old patient presented with a complaint of severe esthetic and functional disorders due to her diagnosis of βT. We initiated orthodontic treatment including a combined orthopedic and functional treatment modality to improve facial appearance. Results: Maxillary restraint and increased mandibular size during treatment along with an increase in the vertical dimension were achieved. The patient presented with Angle class I molar relationship, with reduction of the excessive overjet and deep overbite. Conclusion: Orthodontic treatment comprised of maxillary orthopedic treatment directed especially toward premaxilla with light forces, and mandibular modification by functional appliance along with fixed orthodontic treatment is recommended in βT patients.


beta thalassemia, orthodontic, children

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Shmuel Einy,Hagai Hazan-Molina,Ayelet Ben-Barak,Dror Aizenbud. Orthodontic Consideration in Patients with Beta-Thalassemia Major: Case Report and Literature Review. Journal of Clinical Pediatric Dentistry. 2016. 40(3);241-246.


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