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Original Research

Open Access

Hypophosphatasia: Evaluation of Size and Mineral Density of Exfoliated Teeth

  • Hayashi-Sakai S1,*,
  • Numa-Kinjoh N1
  • Sakamoto M1
  • Sakai J1
  • Matsuyama J1
  • Mitomi T1
  • SanoAsahito T1
  • Kinoshita-Kawano S1

1Niigata University Graduate School of Medical and Dental Sciences, Japan.

DOI: 10.17796/1053-4628-40.6.496 Vol.40,Issue 6,November 2016 pp.496-502

Published: 01 November 2016

*Corresponding Author(s): Hayashi-Sakai S E-mail: sachipro@dent.niigata-u.ac.jp

Abstract

Most cases of hypophosphatasia (HPP) exhibit early loss of primary teeth. Results of microcomputed tomography (micro-CT) analysis of teeth with HPP have not yet been reported. The purpose of the present study was to describe the size and mineral density distribution and mapping of exfoliated teeth with HPP using micro CT. Study design: Seven exfoliated teeth were obtained from a patient with HPP. Exfoliated teeth sizes were measured on micro CT images and mineral densities of the mandibular primary central incisors were determined. Results: Partial dentures were fabricated for the patient to replace the eight primary teeth which had exfoliated. Most primary teeth sizes were within the normal range. The mean values of enamel and dentin mineral densities in teeth with HPP were 1.35 and 0.88 g/cm3 ,respectively, in the mandibular primary central incisors. Conclusion: Mineral density distribution and mapping revealed that the values in teeth with HPP were lower than the homonymous teeth controls in all regions from the crown to apex. Furthermore, it was demonstrated that the differences between HPP and controls were larger on the crown side and the differences tended to converge on the apex side. These results suggested that the present patient showed mild hypomineralization in the primary dentition.

Keywords

hypophosphatasia, , mineral density, micro-CT

Cite and Share

Hayashi-Sakai S,Numa-Kinjoh N,Sakamoto M,Sakai J,Matsuyama J,Mitomi T,SanoAsahito T,Kinoshita-Kawano S. Hypophosphatasia: Evaluation of Size and Mineral Density of Exfoliated Teeth. Journal of Clinical Pediatric Dentistry. 2016. 40(6);496-502.

References

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