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Localized Juvenile Spongiotic Gingival Hyperplasia: Report of Two Cases

  • Eleni-Marina Kalogirou1
  • Konstantina Chatzidimitriou1
  • Konstantinos I. Tosios1,*,
  • Evangelia P. Piperi1
  • Alexandra Sklavounou1

1Department of Oral Medicine and Pathology, Faculty of Dentistry, National and Kapodistrian University of Athens, 2 Thivon Street, 11527 Athens, Greece

DOI: 10.17796/1053-4628-41.3.228 Vol.41,Issue 3,May 2017 pp.228-231

Published: 01 May 2017

*Corresponding Author(s): Konstantinos I. Tosios E-mail:


Objective: Localized juvenile spongiotic gingival hyperplasia (LJSGH) is a painless gingival swelling that histologically exhibits hyperplasia of the non-keratinized stratified squamous epithelium, intercellular edema and spongiosis of the spinus layer, and exocytosis of inflammatory cells. LJSGH pathogenesis remains to be elucidated, while a possible origin from the gingival sulcus epithelium is nowadays proposed. Study design: We report two cases of LJSGH with immunohistochemical evaluation of cytokeratins (CKs) 18 and 19. Results: Both cases concerned 12-year-old boys, who presented with a well-circumscribed bright red pedunculated papillary swelling on the marginal gingiva of the left maxillary lateral incisor. With the provisional diagnosis of LJSGH, the lesions were excised under local anesthesia and histological examination supported the final diagnosis of LJSGH. In both cases, the lesional epithelium showed intense and mild positivity for CK19 and CK18, respectively, while the adjacent normal gingival epithelium expressed CK19, but not CK18, only in the basal cell layer. The postoperative course was uneventful in both patients and no recurrence has been reported. Conclusion: LJSGH is a recently introduced entity that is worth attention in the clinical pediatric dentistry. Clinical and histological examination is required for the final diagnosis, while immunohistochemistry has shed light to LJSGH pathogenesis.


gingiva, hyperplasia, juvenile, spongiotic, immunohistochemistry, cytokeratin 19; cytokeratin 18

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Eleni-Marina Kalogirou,Konstantina Chatzidimitriou,Konstantinos I. Tosios,Evangelia P. Piperi,Alexandra Sklavounou. Localized Juvenile Spongiotic Gingival Hyperplasia: Report of Two Cases. Journal of Clinical Pediatric Dentistry. 2017. 41(3);228-231.


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