Article Data

  • Views 946
  • Dowloads 178

Case Reports

Open Access

Localized Juvenile Spongiotic Gingival Hyperplasia: Report of Two Cases

  • Eleni-Marina Kalogirou1
  • Konstantina Chatzidimitriou1
  • Konstantinos I. Tosios1,*,
  • Evangelia P. Piperi1
  • Alexandra Sklavounou1

1Department of Oral Medicine and Pathology, Faculty of Dentistry, National and Kapodistrian University of Athens, 2 Thivon Street, 11527 Athens, Greece

DOI: 10.17796/1053-4628-41.3.228 Vol.41,Issue 3,May 2017 pp.228-231

Published: 01 May 2017

*Corresponding Author(s): Konstantinos I. Tosios E-mail: ktosios@dent.uoa.gr

Abstract

Objective: Localized juvenile spongiotic gingival hyperplasia (LJSGH) is a painless gingival swelling that histologically exhibits hyperplasia of the non-keratinized stratified squamous epithelium, intercellular edema and spongiosis of the spinus layer, and exocytosis of inflammatory cells. LJSGH pathogenesis remains to be elucidated, while a possible origin from the gingival sulcus epithelium is nowadays proposed. Study design: We report two cases of LJSGH with immunohistochemical evaluation of cytokeratins (CKs) 18 and 19. Results: Both cases concerned 12-year-old boys, who presented with a well-circumscribed bright red pedunculated papillary swelling on the marginal gingiva of the left maxillary lateral incisor. With the provisional diagnosis of LJSGH, the lesions were excised under local anesthesia and histological examination supported the final diagnosis of LJSGH. In both cases, the lesional epithelium showed intense and mild positivity for CK19 and CK18, respectively, while the adjacent normal gingival epithelium expressed CK19, but not CK18, only in the basal cell layer. The postoperative course was uneventful in both patients and no recurrence has been reported. Conclusion: LJSGH is a recently introduced entity that is worth attention in the clinical pediatric dentistry. Clinical and histological examination is required for the final diagnosis, while immunohistochemistry has shed light to LJSGH pathogenesis.

Keywords

gingiva, hyperplasia, juvenile, spongiotic, immunohistochemistry, cytokeratin 19; cytokeratin 18

Cite and Share

Eleni-Marina Kalogirou,Konstantina Chatzidimitriou,Konstantinos I. Tosios,Evangelia P. Piperi,Alexandra Sklavounou. Localized Juvenile Spongiotic Gingival Hyperplasia: Report of Two Cases. Journal of Clinical Pediatric Dentistry. 2017. 41(3);228-231.

References

1. Chang JY, Kessler HP, Wright JM. Localized juvenile spongiotic gingival hyperplasia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106: 411–418, 2008.

2. Darling MR, Daley TD, Wilson A, Wysocki GP. Juvenile spongiotic gingivitis. J Periodontol 78: 1235–1240, 2007.

3. Argyris PP, Nelson AC, Papanakou S, Merkourea S, Tosios KI, Koutlas IG. Localized juvenile spongiotic gingival hyperplasia featuring unusual p16INK4A labeling and negative human papillomavirus status by poly-merase chain reaction. J Oral Pathol Med 44: 37-44, 2015.

4. de Freitas Silva BS, Silva Sant’Ana SS, Watanabe S, Vêncio EF, Roriz VM, Yamamoto-Silva FP. Multifocal red bands of the marginal gingiva. Oral Surg Oral Med Oral Pathol Oral Radiol 119: 3-7, 2015.

5. Mora-Gonzalez D. Localized “Juvenile” Spongiotic Gingival Hyper-plasia in adults; investigation of possible viral etiology and comparison with Pyogenic Granuloma. The University of North Carolina at Chapel Hill, Department Dentistry (Oral and Maxillofacial Pathology), Thesis number 1557162, 2014-http://search.proquest.com/docview/1545898355

6. Allon I, Lammert KM, Iwase R, Spears R, Wright JM, Naidu A. Local-ized Juvenile Spongiotic Gingival Hyperplasia possibly originates from junctional gingival epithelium?–An immunohistochemical study. Histo-pathology 2015 Jul 7. doi: 10.1111/his.12774.

7. Solomon LW, Trahan WR, Snow JE. Localized juvenile spongiotic gingival hyperplasia: a report of 3 cases. Pediatr Dent 35: 360–363, 2013.

8. Flaitz CM, Longoria JM. Oral and maxillofacial pathology case of the month. Localized juvenile spongiotic gingival hyperplasia. Tex Dent J 127: 1312–1313, 1315–1317, 2010.

9. Damm DD. Gingival red patch. Juvenile spongiotic gingival hyperplasia. Gen Dent 57: 448, 451, 2009.

10. MacNeill SR, Rokos JR, Umaki MR, Satheesh KM, Cobb CM. Conser-vative treatment of localized juvenile spongiotic gingival hyperplasia. Clinical Advances in Periodontics 1: 199-204, 2011.

11. Rossmann JA. Reactive lesions of the gingiva: diagnosis and treatment options. The Open Pathology Journal 5: 23-32, 2011.

12. Decani S, Baruzzi E, Sutera S, Trapani A, Sardella A. A case of juvenile spongiotic gingivitis. Ann Stomatol (Roma) 4: 41, 2013.

13. Jiang Q, Yu Y, Ruan H, Luo Y, Guo X. Morphological and functional characteristics of human gingival junctional epithelium. BMC Oral Health 14: 30, 2014.- doi: 10.1186/1472-6831-14-30.

14. Pritlove-Carson S, Charlesworth S, Morgan PR, Palmer RM. Cytokeratin phenotypes at the dento-gingival junction in relative health and inflamma-tion, in smokers and nonsmokers. Oral Dis 3: 19-24, 1997.

15. Mackenzie IC, Gao Z. Patterns of cytokeratin expression in the epithelia of inflamed human gingiva and periodontal pockets. Periodontal Res 28: 49- 59, 1993.

16. MacKenzie IC, Rittman G, Gao Z, Leigh I, Lane EB. Patterns of cyto-keratin expression in human gingival epithelia. J Periodontal Res 26: 468- 478, 1991.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Scopus: CiteScore 1.8 (2023) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Submission Turnaround Time

Conferences

Top