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Original Research

Open Access

The Role of Genetic Factors in the Outbreak Mechanism of Dental Caries

  • Junko Shimomura-Kuroki1,*,
  • Tomoko Nashida2
  • Yukio Miyagawa3
  • Tsuneo Sekimoto1

1Department of Pediatric Dentistry, Nippon Dental University School of Life Dentistry at Niigata, Niigata, Japan

2Department of Biochemistry, Nippon Dental University School of Life Dentistry at Niigata, Niigata, Japan

3Department of Dental Materials Science, Nippon Dental University School of Life Dentistry at Niigata, Niigata, Japan

DOI: 10.17796/1053-4628-42.1.6 Vol.42,Issue 1,January 2018 pp.32-36

Published: 01 January 2018

*Corresponding Author(s): Junko Shimomura-Kuroki E-mail:


Objective: The aim of the present study was to investigate the relationships between cariogenic bacterial infection and single nucleotide polymorphisms (SNPs) in candidate genes associated with dental caries, and to explore the factors related to caries in children.

Study design: Children aged 3 to 11 years were selected. Detection of cariogenic bacteria (Streptococcus mutans, Streptococcus oralis, Streptococcus sobrinus and Lactobacillus) from the plaque of each patient, and SNP analyses of five candidate genes (MBL2, TAS2R38, GLUT2, MMP13 and CA6) were performed using DNA isolated from buccal mucosal cells. The dental caries experience in primary and permanent teeth was determined using the decayed, missing and filled teeth (DMFT) index, and the effects of the observed factors on the DMFT value were analyzed by multiple regression analysis. Results: The results of the multiple regression analysis showed that the DMFT value significantly increased in the presence of S. mutans or S. sobrinus (p < 0.001), while the dmft/DMFT value decreased in the presence of nucleobase C in MBL2 (p < 0.05). Conclusion: These results suggest that the MBL2 gene is related to the pathogenesis of dental caries.


Caries risk, children, cariogenic bacteria, MBL2

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Junko Shimomura-Kuroki,Tomoko Nashida,Yukio Miyagawa,Tsuneo Sekimoto. The Role of Genetic Factors in the Outbreak Mechanism of Dental Caries. Journal of Clinical Pediatric Dentistry. 2018. 42(1);32-36.


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