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Original Research

Open Access

Clinical Characteristics of Localized Aggressive Periodontitis in Primary Dentition

  • Karina Miller1
  • TinaTreloar1
  • Marcio Guelmann1
  • Wellington J. Rody Jr1
  • Luciana M Shaddox1,*,

1College of Dentistry, University of Florida, Gainesville, Florida

DOI: 10.17796/1053-4628-42.2.3 Vol.42,Issue 2,March 2018 pp.95-102

Published: 01 March 2018

*Corresponding Author(s): Luciana M Shaddox E-mail:


Objectives: Due to the low prevalence of localized aggressive periodontitis (LAP), clinical characteristics of LAP in primary dentition are derived from a few case reports/series in the literature. The goal of this study was to determine common clinical characteristics such as bone and root resorption patterns, in a series of cases with LAP in primary dentition. We hypothesize these cases present aggressive periodontal bone destruction starting mostly around first primary molars and atypical root resorption patterns. Study Design: We have evaluated 33 LAP cases in primary dentition for pattern of bone destruction, root resorption and early exfoliation. Results: Cases evaluated were aged 5–12 (mean=8.7 years). Thirty cases presented more severe bone loss on first than second molars, with relatively fast progression to second molars, altered pattern of root resorption, mostly external (n=16) and early exfoliation of primary teeth due to periodontal bone loss, rather than physiologic root resorption (n=11). Conclusions: This study showed common clinical characteristics found in LAP in primary molars, including possible initiation on first primary molars and abnormal root resorption patterns. These characteristics are important to be early identified and treated in order to prevent possible progression into the permanent dentition.


localized aggressive periodontitis, atypical resorption, primary molars

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Karina Miller,TinaTreloar,Marcio Guelmann,Wellington J. Rody Jr,Luciana M Shaddox. Clinical Characteristics of Localized Aggressive Periodontitis in Primary Dentition. Journal of Clinical Pediatric Dentistry. 2018. 42(2);95-102.


1. Susin C, Haas AN, Albandar JM. Epidemiology and demographics of aggressive periodontitis. Periodontol 2000. 65(1):27-45,2014

2. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol. 4(1):1-6,1999

3. Shaddox L, Wiedey J, Bimstein E, et al. Hyper-responsive phenotype in localized aggressive periodontitis. J Dent Res. 89(2):143-148,2010

4. Suzuki JB. Diagnosis and classification of the periodontal diseases. Dent Clin North Am. 32(2):195-216,1988

5. Page RC, Bowen T, Altman L, et al. Prepubertal periodontitis. I. Definition of a clinical disease entity. J Periodontol. 54(5):257-271,1983

6. Baer PN. The case for periodontosis as a clinical entity. J Periodontol. 42(8):516-520,1971

7. Baab DA, Page RC, Morton T. Studies of a family manifesting premature exfoliation of deciduous teeth. J Periodontol. 56(7):403-409,1985

8. Boraz RA. Prepubertal periodontitis: report of a generalized case involving the primary dentition. J Pedod. 9(2):165-168,1985

9. Cogen RB, Al-Joburi W, Caufield PW, Stanley HP, Donaldson K. Peri-odontal disease in healthy children: two clinical reports. Pediatr Dent. 6(1):41-45,1984

10. Mandell RL, Siegal MD, Umland E. Localized juvenile periodontitis of the primary dentition. ASDC J Dent Child. 53(3):193-196,1986

11. Mros ST, Berglundh T. Aggressive periodontitis in children: a 14-19-year follow-up. J Clin Periodontol. 37(3):283-287,2010

12. Sjodin B, Crossner CG, Unell L, Ostlund P. A retrospective radiographic study of alveolar bone loss in the primary dentition in patients with local-ized juvenile periodontitis. J Clin Periodontol. 16(2):124-127,1989

13. Sjodin B, Matsson L, Unell L, Egelberg J. Marginal bone loss in the primary dentition of patients with juvenile periodontitis. J Clin Peri-odontol. 20(1):32-36,1993

14. Miller KA, Branco-de-Almeida LS, Wolf S, et al. Long-Term Clinical Response to Treatment and Maintenance of Localized Aggressive Peri-odontitis: A Cohort Study. J Clin Periodontol.2016

15. Cogen RB, Wright JT, Tate AL. Destructive periodontal disease in healthy children. J Periodontol. 63(9):761-765,1992

16. Bimstein E. Seven-year follow-up of 10 children with periodontitis. Pediatr Dent. 25(4):389-396,2003

17. Fourel J. Periodontosis: a periodontal syndrome. J Periodontol. 43(4):240-255,1972

18. Melnick M, Shields ED, Bixler D. Periodontosis: a phenotypic and genetic analysis. Oral Surg Oral Med Oral Pathol. 42(1):32-41,1976

19. Albandar JM. Aggressive periodontitis: case definition and diagnostic criteria. Periodontol 2000. 65(1):13-26,2014

20. Bartold PM, Van Dyke TE. Periodontitis: a host-mediated disruption of microbial homeostasis. Unlearning learned concepts. Periodontol 2000. 62(1):203-217,2013

21. Kamat M, Puranik R, Vanaki S, Kamat S. An insight into the regulatory mechanisms of cells involved in resorption of dental hard tissues. Journal of oral and maxillofacial pathology : JOMFP. 17(2):228-233,2013

22. Wang Z, McCauley LK. Osteoclasts and odontoclasts: signaling pathways to development and disease. Oral diseases. 17(2):129-142,2011

23. Silva LB, Guimaraes CS, Santos RA. Immunology of root resorption: a literature review. Indian journal of dental research : official publication of Indian Society for Dental Research. 19(4):340-343,2008

24. Arana-Chavez VE, Bradaschia-Correa V. Clastic cells: mineralized tissue resorption in health and disease. The international journal of biochemistry & cell biology. 41(3):446-450,2009

25. Sasaki T. Differentiation and functions of osteoclasts and odontoclasts in mineralized tissue resorption. Microscopy research and technique. 61(6):483-495,2003

26. Hammarstrom L, Lindskog S. General morphological aspects of resorp-tion of teeth and alveolar bone. International endodontic journal. 18(2):93-108,1985

27. Harokopakis-Hajishengallis E. Physiologic root resorption in primary teeth: molecular and histological events. Journal of oral science. 49(1):1-12,2007

28. Zhou D, Hughes B, King GJ. Histomorphometric and biochemical study of osteoclasts at orthodontic compression sites in the rat during indomethacin inhibition. Arch Oral Biol. 42(10-11):717-726,1997

29. Lasfargues JJ, Saffar JL. Inhibition of prostanoid synthesis depresses alve-olar bone resorption but enhances root resorption in the rat. The Anatomical record. 237(4):458-465,1993

30. Uchiyama M, Nakamichi Y, Nakamura M, et al. Dental pulp and peri-odontal ligament cells support osteoclastic differentiation. J Dent Res. 88(7):609-614,2009

31. Fuss Z, Tsesis I, Lin S. Root resorption—diagnosis, classification and treatment choices based on stimulation factors. Dent Traumatol. 19(4):175-182,2003

32. Nakagawa S, Fujii H, Machida Y, Okuda K. A longitudinal study from prepuberty to puberty of gingivitis. Correlation between the occur-rence of Prevotella intermedia and sex hormones. J Clin Periodontol. 21(10):658-665,1994

33. Raber-Durlacher JE, van Steenbergen TJ, Van der Velden U, de Graaff J, Abraham-Inpijn L. Experimental gingivitis during pregnancy and post-partum: clinical, endocrinological, and microbiological aspects. J Clin Periodontol. 21(8):549-558,1994

34. Nasehi A, Mazhari F, Mohtasham N. Localized idiopathic root resorption in the primary dentition: Review of the literature and a case report. Eur J Dent. 9(4):603-609,2015

35. Lunt RC, Law DB. A review of the chronology of eruption of deciduous teeth. J Am Dent Assoc. 89(4):872-879,1974

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