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Original Research

Open Access

Association of Pre- Peri- and Postnatal Factors with Developmental Defects of Enamel in Schoolchildren

  • Fabiana Vargas-Ferreira1,*,
  • Marco Aurelio Peres2
  • Samuel Carvalho Dumith3
  • William Murray Thomson4
  • Flávio Fernando Demarco5

1Universidade Luterana do Brasil, Canoas, Brazil

2Australian Research Center for Population Oral Health, University of Adelaide, Australia

3Federal University of Rio Grande, Brazil

4University of Otago, Dunedin, New Zealand

5Federal University of Pelotas, Pelotas, Brazil

DOI: 10.17796/1053-4628-42.2.8 Vol.42,Issue 2,March 2018 pp.125-134

Published: 01 March 2018

*Corresponding Author(s): Fabiana Vargas-Ferreira E-mail:


Objective: This study estimated the prevalence, extent, buccal distribution and associated factors involving enamel defects in Brazilian schoolchildren. Study design: A cross-sectional study using a multistage cluster random sample of 1,206 8–12-year-old Brazilian schoolchildren was carried out in Pelotas, Brazil. The prevalence of enamel defects in the permanent dentition was determined using the modified Developmental Defects of Enamel index (DDE). Sociodemographic and health data were collected from their mothers using a semi-structured questionnaire. Data were analyzed using Poisson regression modelling for DDE prevalence and negative binomial regression modelling for the extent of DDE. Results: The prevalence of any enamel defects was 64.0% (95% Confidence Interval: 61.4, 67.0); the main types were diffuse opacities (35.0%), demarcated opacities (29.5%) and hypoplasia (3.7%). In general, older children had a lower prevalence and extent of enamel defects than their counterparts (p<0.001). There were no other significant associations. Conclusion: Enamel defects are common, especially among younger children, but the role of pre-, peri- and postnatal exposures remains unclear.


epidemiology, children, developmental defect of enamel, hypoplasia

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Fabiana Vargas-Ferreira,Marco Aurelio Peres,Samuel Carvalho Dumith,William Murray Thomson,Flávio Fernando Demarco. Association of Pre- Peri- and Postnatal Factors with Developmental Defects of Enamel in Schoolchildren. Journal of Clinical Pediatric Dentistry. 2018. 42(2);125-134.


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