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Original Research

Open Access

Dental Caries in Children and Adolescents During and After Antineoplastic Chemotherapy

  • Dorota Olczak-Kowalczyk1,*,
  • Ewa Krasuska-Sławińska2
  • Agnieszka Brożyna2
  • Anna Turska-Szybka1
  • Bożenna Dembowska-Bagińska3

1Department of Paediatric Dentistry, Medical University of Warsaw

2Paediatric Dental Surgery Clinic, Children’s Memorial Health Institute, Warsaw

DOI: 10.17796/1053-4628-42.3.11 Vol.42,Issue 3,May 2018 pp.225-230

Published: 01 May 2018

*Corresponding Author(s): Dorota Olczak-Kowalczyk E-mail: do-k@o2.pl

Abstract

Objective: To assess caries incidence, intensity, and treatment in children and adolescents under/after antineoplastic treatment. Study design: Patients with permanent and mixed dentition were divided into three groups of 60 patients each (5–18 years): CH under chemotherapy; PCH – after chemotherapy; CG – generally healthy subjects. Caries incidence, intensity (DMFT/dmft, DMFS/dmfs), and mean numbers of teeth/surfaces with white spot lesions–WSL (D1+2/d1+2) were assessed following the ICDAS-II criteria. Statistical analysis: Mann-Whitney U test, significance at p≤0.05). Results: Caries incidence was significantly higher in PCH and CH (88.33% and 90%) than in CG (66.66%). Caries intensity was higher in both mixed and permanent dentition in patients under and after chemotherapy. The DMFS/DMFT correlation was the highest in PCH. Treatment indexes for primary and permanent teeth treatment were significantly lower in PCH and CH than CG. Conclusion: Antineoplastic chemotherapy is associated with caries development and its high incidence during/after treatment. As dental hygiene was poor in patients under and after antineoplastic treatment, dental checkups need to be more frequent and thorough.

Keywords

neoplasm, chemotherapy, children, dental caries

Cite and Share

Dorota Olczak-Kowalczyk,Ewa Krasuska-Sławińska,Agnieszka Brożyna,Anna Turska-Szybka,Bożenna Dembowska-Bagińska. Dental Caries in Children and Adolescents During and After Antineoplastic Chemotherapy. Journal of Clinical Pediatric Dentistry. 2018. 42(3);225-230.

References

1. Olczak-Kowalczyk D, Dembowska-Bagińska B, Krasuska-Sławińska E. Treatment needs and dental caries status in children after anticancer therapy who did not receive proper dental care during and after anticancer treatment completion. Dent Med Probl 47(3): 297- 303, 2010 [in Polish].

2. Pajari U, Ollila P, Lanning M. Incidence of dental caries in children with acute lymphoblastic leukemia is related to the therapy used. J Dent Child 62(5): 349-352, 1995.

3. Nunn JH, Welbury, RP, Gordon PH, Kernahan J, Craft AW. Dental caries, and dental abnormalies in children treated by chemotherapy for malignant disease: a study in the north of England Int J Paediatr Dent 1(3): 131-135, 1991.

4. Olczak-Kowalczyk, Daszkiewicz M, Adamowicz-Klepalska B, Miel-nik-Błaszczyk M, Dembowska-Bagińska B, Perek D. The status of denti-tion and oral hygiene in children after anticancer treatment. Ann Acad. Med. 34: 237-255, 2004.

5. Kozarzewska M, Daszkiewicz M, Olczak-Kowalczyk D, Dembows-ka-Bagińska B: Oral pathologic lesions in patients subjected to oncologic treatment. Nowa Stomatol 3: 59-63, 2009 [in Polish].

6. Hesketh PJ. Chemotherapy-induced nausea and vomiting. N Engl J Med 358: 2484-2494, 2008.

7. Epstein JB, Thariat J, Bensadoun RJ, Barasch A, Murphy BA, Kolnick L, Popplewell L, Maghami E. Oral complication of cancer and cancer therapy: from cancer treatment to survivorship. CA Cancer J Clin 62(6): 400- 422, 2012.

8. Park SB, Goldstein D, Krishnan AV, Lin CS, Friedlander ML, Cassidy J, Koltzenburg M, Kiernan MC. Chemotherapy-induced peripheral neuro-toxicity: a critical analysis. CA Cancer J Clin 63(6): 419-437, 2013.

9. Sonis ST. Mucositis: The impact, biology and therapeutic opportunities of oral mucositis. Oral. Oncol 45(12): 1015-1020, 2009.

10. Cheng KKF, Chang AM, Yuen MP. Prevention of oral mucositis in paedi-atric patients treated with chemotherapy; a randomized crossover trial comparing two protocols of oral care. Eur J Cancer 40(8): 1208-1216, 2004.

11. Laine P, Meurman JH, Tenovou J, Murtomaa H, Lindqvist C, Pyrhönen S, teerenhovi L. Salivary flow and composition in lymphoma patients before, during, and after treatment with cytostatic drugs. Eur J Cancer B Oral Oncol 28B(2): 125-128, 1992.

12. Hegde AM, Joshi S, Rai K, Shetty S. Evaluation of oral hygiene, status, salivary characteristics and dental caries experience in acute lympho-blastic leukemia (ALL) children. J Clin Pediatr Dent 35(3): 319-323, 2011.

13. Doðan C Haytaç C, Antmen B, Şaşmaz I, Tanyely A. Oral health status in children with acute lymphoblastic leukemia and lymphoma. Turk J Hematol 18(3): 179-183, 2001.

14. Lautirino D, Petruzzi M. Decayed, missing and filled teeth index and dental anomalies in long-term survivors leukemic children: A prospective controlled study. Med Oral Patol Cir Bucal 17(6): 977-980, 2012.

15. Cubukcu CE, Gunes AM. Dental health status in children with acute lymphoblastic leukemia and data from a hospital-based pediatric dental unit. Balk J Stomat 15(3): 116-120, 2011.

16. Dens F, Boute P, Otten J, Vinckier F, Declerck. Dental caries, gingival health, and oral hygiene of long term survivors of paediatric malignant diseases Arch Dis Child 72 (2):129-132, 1995.

17. Nemeth O, Hermann P, Kivovics P, Garami M. Long-term effects of chemotherapy on dental status of children cancer survivors. Pediatr Hematol Oncol 3(30): 208-215, 2013.

18. Avşar A, Elli M, Darka O, Pinarli G. Long-term effects of chemotherapy on caries formation, dental development, and salivary factors in child-hood cancer survivors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104(6): 781-789, 2007.

19. Höltta P, Alaluusua S, Saarinen-Pihkala UM, Wolf J, Nyström M, Hovi L. Long-erm adverse effects on dentition in children with poor-risk neuro-blastoma treated with high-dose chemotherapy and autologous stem cell transplantation with or without total body irradiation. Bone Marrow Transplant 29(2): 121-127, 2002.

20. Stene T. Effect of vincristine on odontoblasts in rat incisor. Scand J Dent Res 86(50): 346-356, 1978.

21. Jones TE, Henderson JS, Jahnson RB. Effects of doxorubicin on human dental pulp cells in vitro. Cell Bio Toxicol 21(5-6): 207-214, 2005.

22. Lyaruu DM, van Duin MA, Bervoets TJM, Woltgens JHM, Bronckers AL. Effects of actinomycin D on developing hamster molar tooth germs in vitro. Eur J Oral Sci 105(1): 52-58, 1997.

23. Make Y, Katakura A, Moriguchi M, Yamaguchi Y, Yanagisawa T. Inves-tigation of structure of dentin formative disturbances caused by antineo-plastic agents. J Hard Tissue Biology 16(3): 129-136, 2007.

24. Yamamoto T, Sawada T, Onizawa T. Immuno-histochemical demonstra-tion of alpha-tubulin distribution in rat incisor ameloblasts after vinblas-tine administration. Bull Tokyo Dent Coll 38(3): 195-199, 1997.

25. Eisenmann DR, Salama AH, Zaki AM. Effects of vinblastine on calcium distribution pattern and Ca2+,Mg(2+)-adenosine triphosphatase in rat incisor maturation ameloblasts. J Histochem Cytochem: 40(1): 143-151, 1992.

26. Ismail AI, Sohn W, Tellez M, Amaya A, Sen A, Hasson H, Pitts NB. The International Caries Detection and Assessment System (ICDAS): an integrated system for measuring dental caries. Community Dent Oral Epidemiol 35: 170–178, 2007.

27. Cubukçu C, Günes AM. Caries experience of leukemic children during intensive course of chemotherapy. J Clin Pediatr Dent 32 (2): 155-158, 2007.

28. Ponce-Torres E, Ruíz-Rodríguez Mdel S, Alejo-González F, Hernán-dez-Sierra JF. Pozos-Guillén Ade J. Oral ,manifestation in pediatric receiving chemotherapy for acute lymphoblastic leukemia. J Clin Pediatr Dent 34(3): 275-279, 2010.

29. Kung AYH, Zhang S, Zheng LW, Wong GHM, Chu CH., Oral health status of chinese paediatric and adolescent oncology patients with chemo-therapy in Hong Kong: a Pilot Study. Open Dent J 9: 21–30, 2015.

30. Alpaslan G, Alpaslan C, Gögen H, Oğuz A, Cetiner S, Karadeniz C. Disturbances in oral and dental structures in patients with pediatric lymphoma after chemotherapy: a preliminary report. Oral Surg Oral Med Oral Patol Oral Radiol Endod 87(3): 317-321, 1999.

31. Oğuz A, Cetiner S, Karadeniz C, Alpaslan G, Alpaslan C, Pinarli G. Long-term effects of chemotherapy on orodental structures in children with non-Hodgkin’s lymphoma. Eur J Orak SCi 112: 8-11, 2004.

32. Hutton A, Bradwell M, English M, Chapple I.. The Oral health needs of children after treatment for a solid tumour or lymphoma Int J Paediatr Dent 20(1): 15-23, 2010.

33. Näsman M, Björk O, Söderhäll S, Ringdèn O, Dahllöf G. Disturbances in the oral cavity in pediatric long-term survivors after different forms of antineoplastic therapy. Pediatr Dent 16: 217-223, 1994.

34. Pajari U, Yliniemi R. The risk of dental caries in childhood cancer is not high in the teeth are caries-free at diagnosis. Pediatr Hematol and Oncol 18:181-185, 2001.

35. Fleming P, Kinirons MJ. Study of the dental health of children in remis-sion from acute lymphoblastic leukaemia in Northern Ireland. Commu-nity Dent Oral Epidemiol 21(5): 309-312, 1993.

36. Kinirons MJ, Fleming P, Boyd D. Dental caries experience of children in remission from acute lymphoblastic leukaemia in relation to the duration of treatment and the period of time in remission. Int J Paediatr Dent 5(3): 169- 72, 1995.


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