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Original Research

Open Access

Food sugar substitutes: a brief review for dental clinicians

  • Michael W. Roberts1,*,
  • J.Timothy Wright1

1Department of Pediatric Dentistry, University of North Carolina School of Dentistry, 228 Brauer Hall, CB# 7450, Chapel Hill, NC 27599-7450

DOI: 10.17796/jcpd.27.1.bl98u70371655hp8 Vol.27,Issue 1,January 2003 pp.1-4

Published: 01 January 2003

*Corresponding Author(s): Michael W. Roberts E-mail: Mike_Roberts@dentistry.unc.edu

Abstract

The frequent ingestion of fermentable sugars such as sucrose, fructose, glucose and maltose is conducive to the development of caries in the teeth of susceptible individuals. Natural and artificial alternatives to these sugars have been and continue to be developed as non/low-caloric sweeteners. The US Food and Drug Administration have approved four non-caloric sweeteners at present. However, there are several other non-caloric sweeteners being commonly used in other countries. A review of these sweeteners is provided with information on a promising new agent that has not yet gained FDA approval.


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Michael W. Roberts,J.Timothy Wright. Food sugar substitutes: a brief review for dental clinicians. Journal of Clinical Pediatric Dentistry. 2003. 27(1);1-4.

References

1. Jensen ME. Diet and dental caries. Dent Clin North Am 43: 615-633, 1999.

2. Gustfsson BE, Wuensel CE, Lanke LS, et al. The Vipeholm den-tal caries study. The effect of different levels of carbohydrate intake on caries activity in 436 individuals observed for 5 years. Acta Odontol Scand 11: 232-364, 1954.

3. Sheinin A, Makinen KK. Turku sugar studies: an overview. Acta Odontol Scand 34: 405-408, 1976.

4. Harel-Raviv N, Laskaris H, Chu KS. Dental caries and sugar con-sumption into the 21st century. Am J Dent 9: 184-190, 1996.

5. Holt RD. Foods and drinks at 4 daily time intervals in a group of young children. Br Dent J 170: 137-143, 1991.

6. Rugg-Gunn AJ. Diet and dental caries. In The Prevention of den-tal diseases, 2nd Ed. J.J. Murray Ed, Oxford, Oxford University Press, pp 4-114, 1989.

7. Scheinin A, Makinen KK. Turku sugar studies I-XXI. Acta Odontol Scand 33 (Suppl 70): 1-349, 1975.

8. Koulourides T, Bodden R, Keller S, et al: Cariogenicity of nine sugars tested with an intraoral device in man. Caries Res 10: 427-441, 1976.

9. Kandelman D. Sugar, alternative sweeteners and meal frequency in relation to caries prevention: new perspectives. Br J Nutr, 77 (Suppl 1): S121-128, 1997.

10. Sreebny L. Sugar and human dental caries.World Rev Nutr Diet 40: 19-65, 1982.

11. Burt BA. Relative consumption of sucrose and other sugars: has it been a factor in reduced caries experience? Caries Res 27 (Suppl 1): 56-63, 1993.

12. Nabors LO, Gelardi RC. Alternative sweeteners. 2 Ed. New York, Marcel Dekker, Inc., pp 1-450, 1991.

13. Walters DE, Prakash I, Desal N. Active conformations of neo-tame and other high-potency sweeteners. J Med Chem 43: 1243-1245, 2000.

14. Kingborn AD, Kaneda N, Baek N-I, et al. Noncariogenic intense natural sweeteners. Med Res Rev 18: 347-360, 1998.

15. Galvano F, Piva A, Ritieni AL, et al. Dietary strategies to counteract the effects of mycotoxins: a review. J Food Prot 64: 120-131, 2001.

16. Manion CV, Howard J, Ogle B, et al. Aspartame effect in sickle cell anemia. Clin Pharmacol Ther 69: 346-355, 2001.

17. Goerss AL, Wagner GC, Hill WL. Acute effects of aspartame on aggression and neurochemistry of rats. Life Sc 67: 1325-1329, 2000.

18. Stoddard M. Deadly deception: story of aspartame. Dallas, Oderl-wald Press (http://web2.airmai1.net/net/marystod/), pp 1-250, 1998.

19. Wurtman R. Neurochemical changes following high-dose aspartase with dietary carbohydrates. New Engl J Med 389: 429-430, 1983.

20. Wurtman RJ.Aspartame: possible effect on seizure susceptibility. Lancet 2: 1060, 1985.

21. Olney JW, Faber NB, Spitznagel E, et al. Increasing brain tumor rates: is there a link to aspartame. J Neuropatho Exp Neurol 55: 1115-1123, 1996.

22. Mukherjee A, Chakrabarti J. In vivo cytogenetic studies on mice exposed to acesulfame-K, a non-nutritive sweetener. Food Chem Toxicol 35: 1177-1179, 1997.

23. Steinberg L. Effect of sucralose in coffee on plaque pH in human subjects. Caries Res 30: 138-142, 1996.

24. Federal Register 63: 16417, April 3, 1998.

25. Grice HC, Goldsmith LA. Sucralose-an overview of the toxicity data. Food Chem Toxicol 38 (Suppl 2): S1-S6, 2000.

26. Wennerhoim K, Arends J, Birkhed D, et al. Effect of xylitol and sorbitol in chewing-gums on mutans streptococci, plaque pH and mineral loss of enamel. Caries Res 28: 48-54, 1994.

27. Weil A. Natural health, Natural medicine, Boston-New York, Houghton Mifflin Company, p 50, 1995.

28. Bertrand MG. Rechercheszur quelques derives du xylose. Bull Soc Chim Paris 5: 554-557, 1891.

29. Fischer E, Stahel R. Zur kenntnis der xylose. Ber Dtsch Chem Ges 24: 528-539, 1891.

30. Isokangas P,Alanen P,Tiekso J et al. Xylitol chewing gum in caries prevention: a field study in children. J A D A 117: 315—320, 1988.

31. Makinen KK, Bennett CA, Hujoel PP, et al. Xylitol chewing gum and caries rate: a 40 month cohort study. J Dent Res 74: 1904-13, 1995.

32. Makinen KK, Makinen PL, Paper HR, et al. Conclusion and review of the Michigan xylitol program (1986-1995) for the pre-vention of dental caries. Int Dent J 46: 22-34, 1996.

33. Makinen KK. The rocky road of xylitol to its clinical application. J Dent Res 79: 1352-1355, 2000.

34. Makinen KK, Isotupa KP, Kivilompolo T, et al. Comparison of erythritol and xylitol saliva stimulants in the control of dental plaque and mutans streptococci. Caries Res 35: 129-135, 2001.

35. Uhari N, Kontiokari T, Koskela H, et al. Xylitol chewing gum in prevention of acute otitis media: double blind randomized trial. Brit Med J 313: 1180-1184, 1996.

36. Cardello HMAB, Da Silva MAPA, Damaslo MI!. Measurement of the relative sweetness of stevia extract, aspartame and cycla-mate/saccharin blend as compared to sucrose at different con-centrations. Plant Foods Hum Nutr 54: 119-130, 1999.

37. Elkins R. Stevia: nature’s sweetener. Pleasant Grove, UT: Wood-land Publishing, pp 7-10, 1997.

38. Das S, Das AX, Murphy RA, et al. Evaluation of the cariogenic potential of the intense natural sweeteners stevioside and rebau-dioside A. Caries Res 26: 363-366, 1992.

39. Bonvie L, Bonvie B, Gates D. The stevia story. Atlanta, Body Ecology, BED publications, p 5, 1997.

40. Melis J. Effects of chronic administration of Stevia rebaucliana on fertility of rats. J Ethnopharmacol 67: 157-161, 1999.

41. Suttajit N, Vinitketkaumnuen U, Meevatee U, et al. Mutagenicity and human chromosomal effect of stevioside, a sweetener from Stevia rebaucliana Bertoni. Environ Health Perspect Suppl 101(Suppl 3): 53-56, 1993.

42. Chan P, Tomlinson B, Chen Y-J, et al. A double-blind placebo-controlled study of the effectiveness and tolerability of oral ste-vioside in human hypertension. Br J Clin Pharmacol 50: 215-220, 2000.

43. Boeckh EMA, Humboldt G. Efeitos cardiocirculatoris do extrato aquoso total de s. rebaudiana en individuos normais e do este-viosideo em ratos. Ciencia e Cultura 32: 208-291, 1981

44. Matsui M, Matsui K, Kawasaki Y et al. Evaluation of the geno-toxicity of stevioside and steviol using invitro and one in vivo mutagenic assays. Mutagenesis 11: 573-579, 1996.

45. Prakash I, Bishay IE, Desai N, et al. Modifying the temporal pro-file of the high-potency sweetener neotame. J Agric Food Chem 49: 786-789, 2001.

46. Witt J. Discovery and development of neotame. World Rev Nutr Diet 85: 52-57, 1999.

47. Garbow JR, Likos JJ, Schroeder SA. Structure, dynamics, and stability of 􀀁-cyclodextrin inclusion complexes of aspartame and neotame. J Agric Food Chem 49: 2053-2060, 2001.

48. Moynihan PJ. Update on the nomenclature of carbohydrates and their dental effects. J Dent 26: 209-218, 1998.

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