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Van der Woude Syndrome: a report of two cases

  • NM King1,*,
  • CHL Cheong1
  • AME Sanares2

1Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Hong Kong SAR, China

2Department of Paediatric Dentistry, Westmead Centre for Oral Health, Darcy Road, Westmead 2145, NSW, Australia

DOI: 10.17796/jcpd.28.3.t250869457555q58 Vol.28,Issue 3,July 2004 pp.267-271

Published: 01 July 2004

*Corresponding Author(s): NM King E-mail: kingnm@glink.net.hk

Abstract

Van der Woude syndrome is a rare autosomal dominant condition with high penetrance and variable

expression. It consists of a cleft lip and/or palate pits on the vermilion of the lower lip, and hypodontia.

Two cases of congenital lip pits with cleft lip and alveolus and an isolated cleft palate are described

to illustrate the variable presentation of the clinical features and the importance of early recognition of

Van der Woude syndrome because of the genetic implications.


Cite and Share

NM King,CHL Cheong,AME Sanares. Van der Woude Syndrome: a report of two cases. Journal of Clinical Pediatric Dentistry. 2004. 28(3);267-271.

References

1. van der Woude A. Fistula labii inferioris congenital and its associa-tion with cleft palate. Am J Hum Genet 6: 244-256, 1954

2. Cervenka JR, Gorlin J, Anderson VE. The syndrome of pits of the lower lip and cleft lip and/or palate. Genetic considerations. Am J Hum Genet 19: 416-432, 1967.

3. Schneider EL. Lip pits and congenital absence of second premo-lars. Varied expression of the lip pit syndrome. J Med Genet 10: 346- 439, 1973.

4. Ranta R, Stegards T, Rintala AE. Correlations of hypodontia in children with isolated cleft palate. Cleft Palate J 20: 163-165, 1983.

5. Bocian M, Walker AP. Lip pits and deletion 1q32——41. Am J Med Genet 26: 437-443, 1987.

6. Sander A, Schmelzle R, Murray J. Evidence for a microdeletion in 1q32-41 involving the gene responsible for Van der Woude syndrome. Hum Mol Genet 3: 575-578, 1994.

7. Koillinen H, Wong FK, Rautio J, Ollikainen V, Karsten A, Larson O, The BT, Huggare J, Lahermo P, Larsson C, Kere J. Mapping of the second locus for the van der Woude syndrome to chromo-some 1p34. Europ J Hum Gene 9: 747-752, 2001.

8. Kondo S, Schutte BC, Richardson RJ, Bjork BC, Knight AS, Watanabe Y, Howard E, Ferreira de Lima RLL, Daack-Hirsch S, Sander A, McDonald-McGinn DM, Zackai EH, and 14 others. Mutations in IRF6 cause Van der Woude and popliteal ptery-gium syndromes. Nature Genet 32: 285-289, 2002.

9. Burdick AB, Bixler D, Puckett CL. Genetic analysis in families with van der Woude syndrome. J Craniofac Genet Dev Biol 5: 181- 208, 1985.

10. Janku P, Robinow M, Kelly T, Bralley R, Baynes A, Edgerton MT. The van der Woude syndrome in a large kindred: variability, pen-etrance, genetic risks. Am J Med Genet 5: 117-123, 1980.

11. Shprintzen RJ, Goldberg RB, Sidoti EJ. The penetrance and vari-able expression of the Van der Woude syndrome: implications for genetic counseling. Cleft Palate J 17: 52-57, 1980.

12. Rintala AE, Lahti AY, Gylling US. Congenital sinuses of the lower lip in connection with cleft lip and palate. Cleft Palate J 7: 336- 346, 1970.

13. Watanabe YM, Igaku-Hakushi MD, Tomida K. Congenital fistu-las of the lower lip. Oral Surg 4: 709-722, 1951.

14. Sato K. Three case of congenital fistulas of the lower lip. Jap J Orthod 13: 581-584, 1938.

15. Wang MK, Macomber WB. Congenital lip sinuses. Plast Reconstr Surg 18: 319-328, 1956.

16. Rintala AE, Ranta R. Lower lip sinuses: I. Epidemiology, micro-forms and transverse sulci. Br J Plast Surg 34: 26-30, 1981.

17. Ranta R, Rintala AE. Correlations between microforms of the Van der Woude syndrome and cleft palate. Cleft Palate J 20: 159- 162, 1983.

18. Burdick AB. Genetic epidemiology and control of genetic expression in Van der Woude Syndrome. J Craniofac Genet Dev Biol Suppl 2: 99-105, 1986.

19. Warbrick JG, McIntyre JR, Girwood Fergusson A. Remarks on the etiology of congenital bilateral fistula of the lower lip. Br J Plast Surg 4: 254, 1952.

20. Monroe CW. Midline cleft of the lower lip, mandible and tongue with flexion contracture of the neck: case report and review of the literature. Plast Reconstr Surg 38: 312-319, 1966.

21. Grabb WC, Rosenstein SW, Bzoch KR. Cleft lip and palate. Surgery Dental and Speech Aspects, Boston: Little, Brown and Co; 1971.

22. Gorlin RJ et al. Syndromes of the Head and Neck. 3rd ed, New York, McGraw-Hill, 738-739, 1990.

23. Baker BR. Pits of the lip commissures in Caucasoid males. Oral Surg Oral Med Oral Pathol 21: 56-60, 1966.

24. Taylor WB, Lane DK. congenital fistulas of the lower lip: Associations with cleft lip- and palate and anomalies of the extremities. Arch Dermatol 94: 421-424, 1966.

25. Neuman Z, Shulman J. Congenital sinuses of the lower lip. Oral Surg 14: 1415-1420, 1961.

26. Denion E, Capon N, Martinot V, Pellerin P. Neonatal permanent jaw constriction because of oral synechiae and Pierre Robin seqence in a child with van der Woude syndrome. Cleft Palate Craniofac J 39: 115-119, 2002

27. Onofre MA, Brosco HB, Taga R. Relationship between lower-lip fistulae and cleft lip and/or cleft palate in Van der Woude syn-drome. Cleft Palate Craniofac J 34: 261-265, 1997.

28. Schinzel A, Klausler M. The Van der Woude syndrome(domi-nantly inherited lip pits and clefts). J Med Genet 23: 291-294, 1986.

29. Srivastava S, Bang RL. Congenital sinuses of the lower lip: reap-praisal of Van der Woude syndrome on the basis of nine patients. Ann Plast Surg 22: 316-320, 1988.

30. Onofre MA, Brosco HB, Brosco JU, Taga R. Congenital fistulae of the lower lip in Van der Woude syndrome: A histomorphological study. Cleft Palate Craniofac J 36: 79-85, 1999

31. Peterka M, Mullerova Z. Tooth size in children with cleft lip and palate. Cleft Palate J 20: 307-313, 1983.

32. Tan KL, Wong TT, Ong ES, Chiang SP. Congenital lip pits with cleft lip or palate. J Singapore Paediatr Soc 13: 75-78, 1971.


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