Amelogenesis imperfecta: enamel ultra structure and molecular studies
1School of Dental Sciences, Universiti Sains Malaysia
2School of Health Sciences, Universiti Sains Malaysia
3School of Medical Sciences, Universiti Sains Malaysia
DOI: 10.17796/jcpd.28.4.27733r6m51851652 Vol.28,Issue 4,October 2004 pp.319-322
Published: 01 October 2004
Amelogenesis imperfecta (AI) is a hereditary disorder resulting in generalized defects in the enamel.The case
reported here is of a seven-year-old male child with yellow color of all his teeth.Two of his primary molars
were extracted due to dental abscess with advanced root resorption. Histologically hypoplastic enamel layer,
positively birefringent, generalized pitting, roughness with irregular general cracked borders were observed.
Scanning electron microscope, revealed extensive irregular, disorganized rough superficial enamel layer.The
enamel was irregularly decussate with filamentous prisms accompanied by small rounded formations. The
morphological and histological examination of the tooth revealed that this patient has the features of AI.For
genetic study blood sample were collected from the patient and PCR analysis revealed that there is no mutation
in exons 1-7 of AMELX gene on the X chromosome of the patient. Hence, it is probable that the AI of
this patient is not X-linked. It is more likely to be an autosomal mutation.
V.K.Gopinath,K. A. M. Al –Salihi,Chan Yean Yean,Melissa Chan Li Ann,M. Ravichandran. Amelogenesis imperfecta: enamel ultra structure and molecular studies. Journal of Clinical Pediatric Dentistry. 2004. 28(4);319-322.
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