Article Data

  • Views 2797
  • Dowloads 372

Original Research

Open Access

Papain Gel: A New Chemo-Mechanical Caries Removal Agent

  • Sandra Kalil Bussadori1,*,
  • Laura Camacho Castro2
  • Ana Claudia Galvão3

1FUNDECTO/USP, Universidade de São Paulo (USP)

2,Tufts University School of Dental Medicine

3,Universidade de São Paulo (USP)

DOI: 10.17796/jcpd.30.2.xq641w720u101048 Vol.30,Issue 2,December 2005 pp.115-120

Published: 01 December 2005

*Corresponding Author(s): Sandra Kalil Bussadori E-mail: skb@osite.com.br

Abstract

The chemo-mechanical caries removal method has been a solution for treatment of patients seeking alternatives to conventional methods. Among different kinds of chemo-mechanical caries removal sys-tems, Papacarie® – a papain gel – was found to be easy to manipulate, simple and cheap, as well as effective in removing infected tissues.

Cite and Share

Sandra Kalil Bussadori,Laura Camacho Castro,Ana Claudia Galvão. Papain Gel: A New Chemo-Mechanical Caries Removal Agent. Journal of Clinical Pediatric Dentistry. 2005. 30(2);115-120.

References

1. Banerjee A., WatsonT., Kidd E. Dentine caries excavation: a review of current clinical techniques. Br Dent J 2000; 188:476–482.

2. Habib CM, Kronman J, Goldman M. A chemical evaluation of collagen and hydroxyproline alter treatment with GK-101(N-chloroglycine). Pharmacol Ther Dent, v.2, 209–215, 1975.

3. Goldman M, Kronman JH. A preliminary report on a chemome-chanical means of removing caries. J Am Dent Assoc 1976; 93(6): 1149–53.

4. Schutzbank SG, Galaini J, Kronman JH, Goldman M, Clarke REA: A Comparative in vitro study of the effect of GK-101 and GK101E in caries removal. J Dent Res 1978; 57:861–864.

5. Beeley JA, Yip HK, Stevenson AG. Chemomechanical caries removal: a review of the techniques and latest developments. Br Dent J 2000;188:427–430.

6. Ericson D, Zimmerman M, Raber H, Gotrick B, Bornstein R, Thorell J. Clinical evaluation of efficacy and safety of a new method for chemo-mechanicalremovalof caries. Caries Res 1999; 33:171–177.

7. Candido LC. Nova abordagem no tratamento de feridas. São Paulo: Senac-SP 2001. Available: http://www. Feridologo.com.br/curpapaina.htm [2003Dez].

8. Mandelbaum SH, Santis EP, Mandelbaum MHS. Cicatrization: current concepts and auxiliary resources – PartII. An Bras Dermatol 2003; 78(5):525–542.

9. Osato JA, Santiago LA, Remo GM, Cuadra MS, Mori A. Antimicrobial and antioxidant activities of unripe papaya. Life Sci 1999; 53(17):1383–1389.

10. Kimmel JR, Smith EL. Crystalline papain: preparation, specifici-ty and activation. J Biol Chem 1954; 207:514–573.

11. Kimmel Jr, Smith EL. The properties of papain. Adv Enzymol Rel Subj Biochem 1957; 19:267–334.

12. Starley IF, Mohammed P, Schneider G, Bickler SW. The treat-ment of paediatric burns using topical papaya. Burns 1999; 25(7): 636–639.

13. Guzman AV, Guzman MGS. The enzymatic debridement of sup-purations, necrotic lesions and burns with papain. J Int Coll Surg 1953; 20(6):695–702.

14. Flindt M. Health and safety aspects of working with enzymes. Process Biochem 1979; 13(8):3–7.

15. Flindt M. Allergy to amylase and papain. Lancet 1979; 1: 430-432.

16. Velasco MVR. Desenvolvimento e padronização do gel con-tendo papaína para uso tópico. [Dissertação de Mestrado]. São Paulo: faculdade de Ciências Farmacêuticas da USP; 1993.

17. Dawkins G, HewittH, Wint Y, Obiefuna PC, WintB. Antibacterial effects of Carica Papaya fruit on common wound organisms. West Indian Med J 2003; 52(4):290–292.

18. Emeruwa AC. Antibacterial substance from Carica Papaya fruit extract. J Nat Prod 1982; 45(2):123–127.

19. Nagl m, Nguyen VA, Gottardi W, Ulmer H, Hopfl R. Tolerability and efficacy of N-chlorotaurine in comparison with chloramines T for the treatment of chronic leg ulcers with a purulent coating: a randomized phase II study. Br j Dermatol 2003;149(3):590–597.

20. Fuursted K, Hjort A, Knudsen L. Evaluation of bactericidal activity and lag of regrowth (postantibiotic effect) of five anti-septics on nine bacterial pathogens. J Antimicrob Chemoter 1997; 40(2):221–226.

21. Pitten A, Kramer A. Antimicrobial efficacy of antiseptic mouthrinse solutions. Eur J Pharmacol 1999; 55(2):95–100.

22. Chemomechanical caries removal: a comprehensive review of the literature. Int Dent J 2001; 51(4): 291–299.

23. Tonami K, Araki K, Mataki S, Kurosaki N. Effects of chloramines and sodium hypochlorite on carious dentin. J Med Dent Sci 2003;50(2):139–146.

24. Silva LR, Tonolli G, Santos EM, Bussadori SK. Avaliação da bio-compatibilidade in vitro de um novo biomaterial para remoção química e mecânica da cárie. In: 20ª Reunião Anual SBPqO 2003.

25. Pereira AS, Silva LR, Piccinini DPF, Santos EM, Bussadori SK. Comparação in vitro do potencial antimicrobiano de dois mate-riais para remoção químico-mecânica da cárie.

26. Redá SH, Motta LFG, BussadoriSK. Avaliação do gel a base de papaína para remoção química e mecânica da lesão cárie -Papacárie®.

Submission Turnaround Time

Top