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Original Research

Open Access

Stem Cells in Dental Practice: Perspectives in Conservative Pulp Therapies

  • Luciano Casagrande1,*,
  • Letícia Grando Mattuella1
  • Fernando Borba de Araujo1
  • Jacques Eduardo1

1Department of Pediatric Dentistry, School of Dentistry, Universidade Federal do Rio Grande do Sul, Brazil

DOI: 10.17796/jcpd.31.1.t744533472930135 Vol.31,Issue 1,September 2006 pp.25-27

Published: 01 September 2006

*Corresponding Author(s): Luciano Casagrande E-mail: lucianocasagrande@hotmail.com luciano.casagrande@gmail.com

Abstract

Stem cells are undifferentiated cells that have the capacity to self-renew. They have been discovered in many adult tissues, including teeth. The Dental Pulp Stem Cells are involved in dentinal repair by activation of growth factors, released after caries process and have the ability to regenerate the dentin-pulp-like complex. The molecular/cellular research raises the possibilities to grow new tissues and biological structures for clinical application, providing cells for therapies including cell transplantation and tissue engineering.

Keywords

stem-cells – deciduous – teeth – pulp – therapies

Cite and Share

Luciano Casagrande,Letícia Grando Mattuella,Fernando Borba de Araujo,Jacques Eduardo. Stem Cells in Dental Practice: Perspectives in Conservative Pulp Therapies. Journal of Clinical Pediatric Dentistry. 2006. 31(1);25-27.

References

1. Gilbert SF. Developmental Biology, ed 6. Sunderland, Sinauer.; 314- 318. 2000

2. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM. Embryonic stem cell lines derived from human blastocysts. Science.; 282:1145-47. 1998

3. Harada H, Kettunen P, Jung HS, Mustonen T, Wang YA, Thesleff I. Localization of putative stem cells in dental epithelium and their asso-ciation with Notch and FGF signaling. J Cell Biol.; 147:105-120. 1999

4. Fuchs E, Segre JA. Stem cells: a new lease on life. Cell,; 100:143-155, 2000.

5. Blau HM, Brazelton TR, Weimann JM. The envolving concept of a stem cell: entity or function? Cell.; 105:829-841. 2001

6. Friedenstein AJ, Ivanov-Smolenski AA, Chajlakan RK, Gorskaya UF, Kuralesova AI, Latzinik NW, Gerasimow UW. Exp. Hematol.; 6: 440- 44. 1978

7. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR. Science,; 284:143-47. 1999

8. Shi S, Gehron RP, Gronthos S. Comparison of gene expression profiles for human, dental pulp and bone marrow stromal stem cells by cDNA microarray analysis. Bone. 29:532-9. 2001

9. Kuo MY, Lan WH, Lin SK, Tsai KS, Hahn LJ. Collagen gene expres-sion in human dental pulp cell cultures. Arch Oral Biol; 37:945-952. 1992

10. Tsukamoto Y, Fukutani S, Shin-Ike T, Kubota T, Sato S, Suzuki Y, et al. Mineralized nodule formation by cultures of human dental pulp-derived fibroblasts. Arch oral Biol; 37:1045-1055. 1992

11. Nakashima M, Nagasawa H, Yamada Y, Reddi AH. Regulatory role of transforming growth factor-beta, bone morphogenetic protein-2, and protein-4 on gene expression of extracellular matrix proteins and differ-entiation of dental pulp cells. Dev Biol; 162:18-28. 1994

12. Butler WT, Ritchie HH, Bronckers AL. Extracellular matrix proteins of dentine. Ciba Found Symp; 205:107-115. 1997

13. Shiba H, Fujita T, Doi N, Nakamura S, Nakanishi K, Takemoto T, et al. Differential effects of various growth factors and cytokines on the syn theses of DNA, type I collagen, laminin, fribronectin, osteonectin/secreted protein, acidic and rich in cysteine (SPARC), and alkaline phosphatase by human pulp cells in culture. J Cell Physiol; 174:194- 205. 1998

14. Buurma B, Gu K, Rutherford RB. Transplantation of human pulpal and gingival fibroblasts attached to synthetic scaffolds. Eur J Oral Sci; 107:282-9. 1999

15. Buchaille R, Couble ML, Magloire H, Bleicher F. Expression of the small leucine-rich proteoglycan osteoadherin/osteomodulin in human dental pulp and developing rat teeth. Bone; 27:256-70. 2000

16. Onishi T, Kinoshita S, Shintani S, Sobue S, Oshima T. Stimulation of proliferation and differentiation of dog dental pulp cells in serum-free culture medium by insulin-like growth factor. Arch Oral Biol; 44:361-371. 1999

17. Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. PNAS; 97:13625- 30. 2000

18. Gronthos S, Brahim J, Li W, Fisher LW, Cherman N, Boyde A, et al. Stem cell properties of human dental pulp stem pulp stem cell. J Dent Res. 8: 531-5. 2002

19. Miura M, Gronthos S, Mingrui Z, Lu B, Fisher LW, Robey PG, Shi S. SHED: stem cells from human exfoliated deciduous teeth. PNAS, 10:5807-5812. 2003

20. Tziafas D. Basic mechanisms of cytodifferentiation and dentinogenesis during pulp repair. Int J Dev Biol.; 39:281-90. 1995

21. Smith AJ, Cass IDYM, Perry H, Begue-Kirn C, Ruch CV, Lesot H. Reactionary dentinogenesis. Int J Dv Biol.; 39:273-80. 1995

22. About I, Bottero MJ, De Denato P, Camps J, Franquin JC, Mitsiadis TA. Human dentin production in vitro. Exp Cell Res.; 258:33-41. 2000

23. Téclès O, Laurent P, Zygouritsas S, Burger, AS, Camps J, Dejou J, About I. Activation of human dental pulp progenitor/stem cells in response to odontoblast injury. Arch Oral Biol.; 50:103-8. 2005

24. Finkelman RD, Mohan S, Jennings JC, Taylor AK, Jepsen S, Baylink DJ. Quantification of growth factors IGF-I, SGF/IGF-II and TGF-beta in human dentin. J Bone Miner Res.; 5:717-22. 1990

25. Ruch JV, Lesot H, Bègue-Kirn C. Odontoblast differentiation. Int J Dev Biol. 39:51-68. 1995

26. Martin P. Wound healing; aiming for perfect skin regeneration. Science. 276:75-81. 1997

27. D’Souza RN, Cavender A, Sood R, Tarnuzzer R, Dichinson D, Roberts A, et al. Dental abnormalities in mice lacking funtional TGF-1. Int J Dev Biol. 23:119-31. 1998

28. McDonald RE, Avery DR. Treatment of deep caries, vital pulp expo sure, and pulpless teeth. In: RE McDonald, DR Avery, eds. Dentistry for the child and adolescent. 6a ed. Philadelphia: CV Mosby Co :428-454. 1994

29. American Academy of Pediatric Dentistry. Reference Manual: Guidelines for pulp therapy for primary and Young permanent teeth. Pediatr Dent.; 67:70. 2001

30. Tedder TF, Steeber DA, Chen A, Engel P. The selectins; vascular adhe-sion molecules. Faseb J 9:866-73. 1995

31. Mathieu S, Battari AE, Dejou J, About I. Role of injured endothelial cells in the recruitment of human pulp cells. Arch Oral Biol. 50:109- 113. 2005

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