Title
Author
DOI
Article Type
Special Issue
Volume
Issue
Effect of Formaldehyde on Rat Liver in Doses Used in Pulpotomies
1Department of Pediatric Dentistry, University of Murcia, Spain
2Department of Pediatric Dentistry, International University of Catalonia, Spain
3Department of Endodontics, University of Barcelona, Spain
*Corresponding Author(s): Boj J.R E-mail: 16388jrb@comb.es
Many studies have questioned the toxic effects of formocresol, one of which is its systemic distribution. This study focused on determining whether there was risk of acute hepatic lesion after the use of intravenous formaldehyde in doses for multiple pulpotomies in rats. Histological and biochemical changes were evaluated. Results showed that very high doses of formaldehyde injected into rats, doses that were much higher than those given for multiple pulp treatments in a single session in Pediatric Dentistry, showed no signs of liver toxicity.
formocresol, formaldehyde, pulpotomy, liver toxicity, systemic distribution
Cortés O,Fernández J,Boj J.R,Canalda C. Effect of Formaldehyde on Rat Liver in Doses Used in Pulpotomies. Journal of Clinical Pediatric Dentistry. 2007. 31(3);179-182.
1. American Academy of Pediatric Dentistry. Guidelines on pulp therapy for primary and young permanent teeth. Pediatr. Dent 26: 115-119, 2004.
2. Camp JH. Pulp therapy for primary and young permanent teeth. Dent Clin North Am 28: 651-668, 1984.
3. Ranly DM. Pulpotomy therapy for primary teeth: new modalities for old rationales. Pediatr Dent 16: 403-409, 1994.
4. Avram D, Pulver F. Pulpotomy medicaments for vital primary teeth. J Dent Child 56: 426-434, 1989.
5. Belanger GK. Pulp therapy for the primary dentition. In: Pinkham JR, Casamassimo PS, Fields HW, Mc Tigue DJ, Nowak AJ. Pediatric Dentistry. Infancy through adolescence. Saunders, Philadelphia: 1988, page. 260-265.
6. Fuks AB, Bimstein E. Clinical evaluation of diluted formocresol pulpotomies in primary teeth of school children. Pediatr Dent 3: 321-324, 1981.
7. Morawa AP, Straffon LH, Han SS, Corpron RE. Clinical evaluation of pulpotomies using diluted formocresol. J Dent Child 42: 360-363, 1975.
8. Berger JE. Pulp tissue reaction to formocresol and zinc-oxide eugenol. J Dent Child 32: 13-28, 1965.
9. Cortés D, Boj JR, Canalda C, Carreras M. Pulpal tissue reaction to formocresol vs. ferric sulfate in pulpotomized rat teeth. J Clin Pediatr Dent 21: 247-253, 1997.
10. Avram DC, Pulver F. Pulpotomy medicaments for vital primary teeth. Surveys to determine use and attitudes in pediatric dental practice and in dental schools throughout the world. J Dent Child 56: 426-433, 1989.
11. Alacam A. Pulpal tissue changes following pulpotomies with formocresol, glutaraldehyde-calcium hydroxyde and glutaraldehydezinc oxide eugenol pastes in primary teeth. J Pedodont 13:123-132, 1989.
12. Fuks A, Holan G, Davis JM, Eidelman E. Ferric sulfate versus dilute formocresol in pulpotomized primary molars: long-term follow up. Pediatr Dent 19: 327-330, 1997.
13. García-Godoy F. Penetration and pulp response by two concentrations of formocresol using two methods of application. J Pedodont 5: 102- 135, 1981.
14. Fuks AB, Bimstein E, Bruchim A. Radiographic and histologic evaluation of the effect of two concentrations of formocresol on pulpotomized primary and young permanent teeth in monkeys. Pediatr Dent 5: 9-13, 1983.
15. Prakash C, Chandra S, Jaiswal JN. Formocresol and glutaraldehyde pulpotomies in primary teeth. J Pedodont 13: 314-322, 1989.
16. Barsky R, Anderson R, Milnes A, Legault V. Formocresol in primary teeth. J Can Dent Assoc 64: 466-467, 1998.
17. Holan G, Fuks A, Keltz N. Success rate of formocresol Pulpotomy in primary molars restored with stainless steel crown vs. amalgam. Pediatr Dent 24: 212-216, 2002.
18. Jeng HW, Feigal RJ, Messer HH. Comparison of the cytotoxicity of formocresol, formaldehyde, cresol and glutaraldehyde using human pulp fibroblast cultures. Pediatr Dent 9: 295-300, 1987.
19. Ranly DM. Formocresol toxicity; current knowledge. Act Odontol Pediatr 5: 93-98, 1984.
20. Swenberg JA,Kerns WD, Mitchell RJ,Gralla EJ, Paukov RL. Induction of squamous cell carcinoma of the rat nasal cavity by inhalation exposure to formaldehyde vapour. Cancer Res 40: 3398-3402, 1990.
21. Lewis BB, Chester SB. Formaldehyde in dentistry: a review of mutagenic and carcinogenic potential. J Am Dent Assoc 103: 429-434, 1981.
22. Wu MK,Wang ME. Antibody formation to dog pulp tissue altered by a paste containing paraformaldehyde. Int Endod J 22:133-137,1989.
23. Block RM, Lewis RD, Sheats JB, Burke JH. Antibody formation to dog pulp tissue altered by formocresol within the root canal. Oral Surg 45: 282-292, 1978.
24. Swenberg JA and others. Induction of squamous cell carcinoma of the rat nasal cavity by inhalation exposure to formaldehyde vapors. Cancer Res 40:3398-3402, 1980.
25. Myers DR, Shoaf HK, Dirksen TR, Pashley DH, Whitford GM, Reynolds KE. Distribution of 14C-formaldehyde after pulpotomy with formocresol. J Am Dent Assoc 96: 805-813, 1978.
26. Pashley E L, Myers D R., Pashley D H. Systemic Distribution of 14Cformaldehyde from formocresol treated pulpotomy sites. J Dent Res 59: 603-608, 1980.
27. Myers DR, Pashley DH, Whitford GM. Tissue changes induced by the absorption of formocresol from pulpotomy sites in dogs. Pediatr Dent 5; 6-8, 1983.
28. Ranly DM. Assessment of the systemic distribution and toxicity of formaldehyde following pulpotomy treatment: part one. J Dent Child 52: 431-434, 1985.
29. Ranly DM, Horn D. Assessment of the systemic distribution and toxicity of formaldehyde following pulpotomy treatment: part two. J Dent Child 54: 40-44, 1987.
Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.
Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.
Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.
JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.
Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.
BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.
Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.
Scopus: CiteScore 1.8 (2023) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.
Top