Title
Author
DOI
Article Type
Special Issue
Volume
Issue
The Effectiveness of Vitamin “E” in the Treatment of Oral Mucositis in Children Receiving Chemotherapy
1Pediatric Dentistry Pediatric and Community Dentistry department. Faculty of Dentistry, University of Alexandria, Egypt
2Community Dentistry Pediatric and Community Dentistry department. Faculty of Dentistry, University of Alexandria, Egypt
3Clinical Oncology Clinical Oncology department. Faculty of Medicine, University of Alexandria, Egypt
4Shark El – Madina Hospital. Alexandria, Egypt
*Corresponding Author(s): Azza A. El–Housseiny E-mail: ahussini@hotmail.com
The aim of this study was to study the effect of vitamin "E" in the treatment of oral mucositis. 80 patients with oral mucositis were randomly distributed into 2 groups: group A, topically applied vitamin "E" and group B, vitamin "E" was given systemically. The 2 groups were evaluated for 5 days. Results showed that in group A grades of oral mucositis improved significantly, while in group B no significant improvement was noticed.
It is concluded that topical application of 100 mg vitamin "E" twice daily is an effective measure for the treatment of chemotherapy-induced oral mucositis.
mucositis, vitamin E, oral
Azza A. El–Housseiny,Susan M. Saleh,Ashraf A. El–Masry,Amany A. Allam. The Effectiveness of Vitamin “E” in the Treatment of Oral Mucositis in Children Receiving Chemotherapy. Journal of Clinical Pediatric Dentistry. 2007. 31(3);167-170.
1. DM, Bray F, Ferlay J, Pisani P. Global Cancer Statistics, 2002.
CA: Cancer J Clin 55: 74-108, 2005.
2. Shochat SJ, Fremgen AM, Murphy SB, Hutchison C, Donaldson SS, Haase GM, et al. Childhood Cancer: Patterns of Protocol Participation in a National Survey. CA: Cancer J Clin 51: 119-30, 2001.
3. Collard MM, Hunter ML. Oral and dental care in acute lymphoblastic leukemia: A survey of United Kingdom children's cancer study group centers. Int J Pediatr Dent 11: 347-51, 2001.
4. Sonis ST, Sonis AL, Lieberman A. Oral complications in patients receiving treatment for malignancies other than of the head and neck. J Am Dent Assoc 97: 468-72,1978.
5. Sonis AL, Sonis ST. Oral complications of cancer chemotherapy in pediatric patients. J Pedod 3: 122-8, 1979.
6. Williams MC, Lee GTR. Childhood leukemia and dental considera-tions. J Clinic Pediatr Dent 15: 160-4, 1991.
7. Sonis ST. Mucositis as a biological process: a new hypothesis for the development of chemotherapy-induced stomatotoxicity. J Oral Oncol 34: 39-43, 1998.
8. Epstein JB, Schubert MM. Oral mucositis in myelosuppressive cancer therapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 88:273-6, 1999.
9. Woo SB, Sonis ST, Monopoli MM, Sonis AL. A Longitudinal study of oral ulcerative mucositis in bone marrow transplant recipients. Cancer 72: 1612-7, 1993.
10. Alpaslan G, Alpaslan C, Gögen H, O_uz A, Çetiner S, Karadeniz C. Disturbances in oral and dental structures in patients with pediatric lymphoma after chemotherapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 87: 317-21, 1999.
11. Köstler WJ, Hejna M, Wenzel C, Zielinski CC. Oral mucositis com-plicating chemotherapy and / or radiotherapy: Options for prevention and treatment. CA: Cancer J Clin 51: 290-315, 2001.
12. Cheng CF, Huang WH, Tsai TP, Ko EW, Liao YF. Effects of cancer therapy on dental and maxillofacial development in children: Report of case. J Dent child 67: 218-22, 2000.
13. Flaitz CM, Hicks MJ. Oral candidiasis in children with immune suppression: Clinical appearance and therapeutic considerations.
J Dent child 66: 161-6, 1999.
14. Guggenheimer J, Moore PA. Xerostomia: Etiology, Recognition
and treatment. J Am Dent Assoc 134: 61-9, 2003.
15. Lowe O. Oral concerns for the pediatric cancer patient. J Pedod, 1986; 11: 35-46.
16. Parulekar W, Mackenzie R, Bjarnason G, Jordan RCK. Scoring oral mucositis. J Oral Oncol 34: 63-71, 1998.
17. Brigelius-Flohé R, Traber MG. Vitamin E: function and metabolism. FASEB J 13: 1145-55, 1999.
18. Dutta A, Dutta SK. Vitamin E and its role in the prevention of Atherosclerosis and Carcinogenesis: A Review. J Am College Nutri 22: 258-68, 2003.
19. Shils M, Olson J, Shike M, Ross AC. Vitamin E. In: Traber MG. Modern Nutrition in Health and Disease, ninth Edition. Baltimore: Williams& Wilkins, 1999, 347-62.
20. Starasoler S, Haber GS. Use of vitamin E oil in primary herpes gin-givostomatitis in an adult. N Y State Dent J 44: 382-3, 1978.
21. Wadleigh RG, Redman RS, Graham ML, Krasnow SH, Anderson A, Cohen MH. Vitamin E in the treatment of chemotherapy-induced mucositis. Am J Med 92: 481-4, 1992.
22. Osaki T, Ueta E, Yoneda K, Hirota J, Yamamoto T. Prophylaxis of oral mucositis associated with chemoradiotherapy for oral carcinoma by Azelastine hydrochloride (Azelastine) with other antioxidants. Head Neck 16: 331-9, 1994.
23. Lopez I, Goudou C, Ribrag V, Sauvage C, Hazebroucq G, Dreyfus F. Treatment of mucositis with vitamin E during administration of neu-tropenic antineoplastic agents. J Ann Med Interne 145: 405-8, 1994.
24. Ferreira PR. Protective effect of Vitamin E (VE) In Head and Neck can-cer radiation induced mucositis:A Double-blind randomized trial. Head and Neck 26: 313-2, 2004;.
25. Yörük Ö, Sezen O, Özkan A, Erdo_an F, Kzltunç A, Gündo_du C. Vitamin E and L-carnitine, separately or in combination, in the preven-tion of radiation-induced oral mucositis and myelosuppression: a con-trolled study in a rat model. J Radiat Res 47: 91-102, 2006.
26. Rubenstein EB, Peterson DE, Schubert M, Keefe D, McGuire D, Epstein J, et al. Clinical practice guidelines for the prevention and treat-ment of cancer therapy-induced oral and gastrointestinal mucositis. Cancer 100(S9): 2026-46, 2004.
27. Plevovà P. Prevention and treatment of chemotherapy-and radiothera-py-induced oral mucositis. J Oral Oncol 35: 453-470, 1999.
28. Sonis ST, Oster G, Fuchs H, Bellm L, Bradford WZ, Edelsberg J, et al. Oral mucositis and the clinical and economic outcomes of hematopoi-etic stem-cell transplantation. J Clinic Oncol 19: 2201-5, 2001.
Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.
Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.
Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.
JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.
Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.
BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.
Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.
Scopus: CiteScore 1.8 (2023) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.
Top