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AIDS in Children—Epidemiology, Clinical Course, Oral Manifestations and Management

  • Meenu Mittal1,*,

1Department of Pedodontics, SGT Dental College, Gurgaon, Haryana, India

DOI: 10.17796/jcpd.34.2.m2055qnv417n51x5 Vol.34,Issue 2,March 2010 pp.95-102

Published: 01 March 2010

*Corresponding Author(s): Meenu Mittal E-mail: meenufeb20@hotmail.com

Abstract

HIV/AIDS has gained enormous proportion globally. In 2007, there were an estimated 33 million people living with HIV and an estimated 270,000 HIV infected children younger than 15 years died because of AIDS,HIV/AIDS can manifest in different forms and in present day scenario, it is imperative that dentists know its clinical presentation and management. Oral manifestations are one of the earliest indicators of HIV infection and progression in children, as in adults, although the specific manifestations differ between adults and children. The aim of this paper is to briefly review, on the basis of literature, the AIDS epidemiology, transmission,clinical course, oral manifestations and their management in children.

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Meenu Mittal. AIDS in Children—Epidemiology, Clinical Course, Oral Manifestations and Management. Journal of Clinical Pediatric Dentistry. 2010. 34(2);95-102.

References

1. UN Aids 2008 Report on the Global AIDS Epidemic.

2. Ramos Gomez F. Dental considerations for the pediatric AIDS/HIV patient. Oral Dis, 8(Suppl 2), 49–54, 2002.

3. DeCock KM, Fowler MG, Mercier E et al. Prevention of mother to child HIV transmission in resource poor countries. J Am Med Assoc, 283: 1175–1182, 2000.

4. McCarthy GM, Ssali CS, Bedranash H, Jorge J et al. Transmission of HIV in the dental clinic and elsewhere. Oral Dis, 8 (Suppl 2), 126–135, 2002.

5. Kengeya-Kayondo JF, Malamba SS, Nunn AJ, Seeley JA, Ssali A, Mulder DW. Human immunodeficiency virus (HIV 1) seropositivity among children in rural population of South-West Uganda: probable routes of exposure. Ann Trop Pediatr, 15(2): 115–20, 1995.

6. Mulder DW, Nunn A, Kamali A, Kengeya- Kayondo JF. Post natal incidence of HIV-1 infection among children in a rural Ugandan popu-lation: no evidence for transmission other than mother to child. Trop Med Int Health, 1(1): 81–5, 1996.

7. Hauri AM, Armstrong GL and Hutin YJ. The global burden of disease attributable to contaminated injections given in health care settings. Int J STD AIDS Jan; 15(1): 7–16, 2004.

8. Kiwanuka N, Gray RH, Serwadda D, Li X, Sewankamboo NK, Kigozi G, Lutalo T, Nalugoda F, Wawer MJ. The incidence of HIV-1 associ-ated with injections and transfusions in a prospective cohort, Rakai, Uganda. AIDS, 23; 18(2): 342–4, 2004.

9. Schmid GP, Buve A, Mugyenyi P, Garnett GP, Hayes RJ, Williams BG, Calleja DG, De Cock KM, Whitworth JA et al. Transmission of HIV-1 in sub-Saharan Africa and effect of elimination of unsafe injections. Lancet, 363(9407): 482–8, 2004.

10. Bulterys M and Fowler MG. Prevention of HIV infection in children. Pediatr Clin North Am, 47(1): 241–60, 2000.

11. Connor EM, Sperling RS, Gelber R, Kiselev P, Scott G, O’Sullivan MJ, VanDyke R, Bey M, Shearer W, et al. Reduction of maternal-infant transmission of human immunodeficiency virus type1 with zidovudine treatment, New Eng J Med, Vol 331: 1173–1180, 1994.

12. Harrison’s Principles of Internal Medicine, 2000, 15th ed., Mc Graw Hills

13. Mylonakis E, Paliou M, Lally M, Flanigan TP, Rich JD. Laboratory testing for infection with human immunodeficiency virus: established and novel approaches. Am J Med; 109(7): 568–76, 2000.

14. Kleinman S, Barsch MP, Hall L, Thomson R, Glynn S, Gallahan D, et al. False positive HIV 1 test results in a low risk screening setting of voluntary blood donation. Retrovirus epidemiology donor study. JAMA, 280(12): 1080–5, 1998.

15. European Collaborative Study. Children born to women with HIV-1 infection: natural history and risk of transmission(letter). Lancet, 337(8736): 253–60, 1991.

16. Leggott PJ. Oral manifestations of HIV infection in children. Oral Surg Oral Med Oral Pathol, 73: 187–92, 1992.

17. Spira R, Lepage P, Msellati P, Van de Perre P, Leroy V, Simmonon A, Karita E, et al. Natural history of human immunodeficiency virus type1 infection in children: A five year prospective study in Rwanda. Pedi-atrics, 104, No 5: 1–9, 1999.

18. Pahwa S, Kaplon M, Fikrig S,et al. Spectrum of human T cell lym-photropic virus type III infection in children. Recognition of sympto-matic, asymptomatic and seronegative patients. JAMA, 255(17): 2299–305, 1986.

19. Wiznia A, Rubinstein A. Pediatric infections and therapy. AIDS, 2 Suppl 1: S195–9, 1988.

20. Krasinski K, Borkowsky W, Bonk S, Lawrence R, Chandwani S. Bac-terial infections in human immunodeficiency virus-infected children. Pediatr Infect Dis J, 7(5): 323–8, 1988.

21. Scott GB, Hutto C, Makusch RW, Mastrucci MT, O’Connor T, Mitchell CD, et al. Survival in children with perinatally acquired human immun-odeficiency virus type 1 infection. N Eng J Med, 321(26): 1791–6, 1989.

22. Greenspan JS, Greenspan D. The epidemiology of the oral lesions of HIV infection in the developed world. Oral Dis, 8(Suppl.2), 34–39, 2002.

23. Ramos Gomez FJ, Petru A, Hilton JF, Canchola AJ, Wara D & Greenspan JS. Oral manifestations and dental status in pediatric HIV infection. Int J Ped Dent, 10: 3–11. 2000.

24. Centre for disease control and prevention. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR Recomm Rep. Dec 18; 41(RR-17): 1–19, 1992.

25. Pizzo PA and Wilfret CM. Markers and determinants of disease pro-gression in children with HIV infection. The Pediatric AIDS Sienna Workshop II. J Acquir Immun Defic Syndr Hum Retrovirol, 8(1): 30–44, 1995.

26. Centre for disease control and prevention. 1995 revised guidelines for prophylaxis against Pneumocystitis carinii pneumonia for children infected with or perinatally exposed to human immunodeficiency virus. MMWR Recomm Rep. Apr 28; 44(RR-4): 1–11, 1995.

27. Patton LL, Shugars DC. Immunologic and viral markers of HIV-1 dis-ease progression: Implications for dentistry. JADA, 130: 1313–1322, 1999.

28. O’Brien WA, Hartigan PM, Martin D, Esinhart J, Hill A, Benoit S, et al. Changes in plasma HIV-1 RNA and CD4+ lymphocyte counts and the risk of progression to AIDS. New Eng J Med, Feb; 334: 426–431, 1996.

29. Quinn TC, Wawer MJ, Sewankamboo N, Serwadda D, LI C, et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1. New Eng J Med, 342: 921–929, 2000.

30. Patton LL. HIV disease. Dent Clin N Am, 47: 467–492, 2003.

31. EC clearinghouse. Classification and diagnostic criteria for oral lesions in HIV Infection and WHO Collaborating Centre on oral manifesta-tions of the immunodeficiency virus. J Oral Pathol Med, 22(7): 289–91, 1993.

32. Pongsiriwet S, Iamaroon A, Kanjanavanit S, et al. Oral lesions and dental caries status in perinatally HIV infected children in Northern Thailand. Int J Pediatr Dent, 13: 180–185, 2003.

33. Olaniyi TO, Sunday P. Oral manifestations of HIV infection in 36 Nigerian children. J Clin Pediatr Dent, 30(1): 89–92, 2005.

34. Barasch A, Safford MM, Catalanotto FA, Fine DH, Katz RV. Oral soft tissue manifestations in HIV positive vs. HIV negative children from an inner city population: a two year observational study. Pediatr Dent, 22(3): 215–20, 2000.

35. Khongkunthian P, Grote M, Isaratanam W, Piyaworawong S, Reichart PA. Oral manifestations in 45 HIV-positive children from Northern Thailand. J Oral Pathol Med, 30 Issue 9, 549–52, 2001.

36. Magalhaes MG, Bueno DF, Serra E, Goncalves R. Oral manifestations of HIV positive children. J Clin Pediatr Dent, 25(2): 103–6, 2001.

37. Naidoo S, Chikte U. Oro-facial manifestations in pediatric HIV: a com-parative study of institutionalized and hospital outpatients. Oral Dis, 10(1): 13–8, 2004.

38. Santos LC, Castro GF, deSouza IP, Oliveira RH. Oral manifestations related to immunosuppression degree in HIV-positive children. Braz Dent J, 12: 135–8, 2001.

39. Kozinetz CA, Carter AB, Simon C, Hicks MJ, Rossmann SN, Flaitz CM, et al. Oral manifestations of pediatric vertical HIV infection. AIDS Patient Care and STDs, 13(2): 89, 2000.

40. Fonseca R, Cardoso AS, Pomarico I. Frequency of oral manifestations in children infected with human immunodeficiency virus. Quintessence Int, 31(6): 419–22, 2000.

41. Campo J, Del Romero J, Castilla J, Garcia S, Rodriguez C, Bascones A. Oral candidiasis as a clinical marker related to viral load, CD4 lym-phocyte count and CD4 lymphocyte percentage in HIV-infected patients. J Oral Pathol Med, 31(1): 5–10, 2002.

42. Patton LL, Mckaig RG, Strauss RP, Eron JJ Jr. Oral manifestations of HIV in southeast USA population. Oral Dis, 4(3): 164–9, 1998.

43. Margiotta V, Campisi G, Mancuso S, Accurso V, Abbadessa V. HIV infection: oral lesions, CD4+ cell count and viral load in an Italian study population. J Oral Pathol Med, 28: 173–7, 1999.

44. Sirois DA. Oral manifestations of HIV disease. Google.com.1998 Oct/Nov; No 5 & 6, Vol 65: 322–332.

45. Glick M. Orofacial disorders in children with HIV disease. Dent Clin N Am, 45: 259–271, 2005.

46. 1999 International Workshop for a classification of periodontal diseases and conditions. Papers. Oak Brook, Illinois, October 30–November 2, 1999.

47. Flaitz C, Wullbrandt B, Sexton J, Bourdon T, Hicks J. Prevalence of orodental findings in HIV infected Romanian children. Pediatr Dent, Jan Feb; 23: 44–50, 2001.

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