Title
Author
DOI
Article Type
Special Issue
Volume
Issue
Myofibroma of the Gingiva: Report of a Case
1Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Ege University, Bornova, İzmir, Turkey
2Department of Oral Pathology, Ege University, Bornova, İzmir, Turkey
*Corresponding Author(s): Banu Özveri Koyuncu E-mail: banuozverikoyuncu@yahoo.com
Myofibroma is a benign mesenchymal neoplasm composed of myofibroblasts which has been described with different synonyms since the first report in 1951. It occurs most commonly as a solitary lesion of soft tissue,skin, or bone in infancy. The prognosis of oral myofibromas is excellent, and surgical excision is curative. Recurrence is rare. Awareness and recognition of this benign tumor is important to establish the correct diagnosis and avoid morbidity of unnecessary aggressive therapy. This report describes a myofibroma of the gingiva in a 14 year old girl and is reported together with the conventional histologic, and immunohistochemical findings. The tumor showed rapid increase in size and clinical features suggestive of malignancy. However, on histopathologic evaluation it was diagnosed as a benign neoplasm, and this diagnosis was supported by immunohistochemical markers. The spindle cells were immunopositive for smooth muscle actin,and vimentin but were negative for desmin and S-100 protein. The patient was treated with surgical excision,and is followed-up for 33 months without any signs of recurrence.
Oral myofibroma, infant, spindle cell neoplasm
Banu Özveri Koyuncu,Mert Zeytinoğlu,Taha Ünal,Bülent Zeytinoğlu. Myofibroma of the Gingiva: Report of a Case. Journal of Clinical Pediatric Dentistry. 2010. 34(3);253-258.
1. Fletcher C.D., Unni K.K., Mertens F. World Health Organization classification of tumors. Pathology and genetics. Tumors of soft tissue and bone. Lyon: IARC Press, 2002.
2. Williams J.O., Schrum D. Congenital fibrosarcoma: report of a case in a newborn infant. AMA Arch Pathol, 51: 548–52, 1951.
3. Stout A.P. Juvenile fibromatoses. Cancer, 7: 953–78, 1954.
4. Chung E.B., Enzinger F.M. Infantile myofibromatosis. Cancer, 48: 1807–18, 1981.
5. Beham A., Badve S., Suster S., Fletcher C.D. Solitary myofibroma in adults: clinicopathologic analysis of a series. Histopathology, 22: 335–41, 1993.
6. Montgomery E., Speight P.M., Fisher C. Myofibromas presenting in the oral cavity: a series of 9 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 89: 343–8, 2000.
7. Foss R.D., Ellis G.L. Myofibromas and myofibromatosis of the oral region: a clinicopathologic analysis of 79 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 89: 57–65, 2000.
8. Darby I., Skalli O., Gabbiani G. Alpha-smooth muscle actin is transiently expressed by myofibroblasts experimental wound healing. Lab Invest, 63: 21–9, 1990.
9. Speight P.M., Dayan D., Fletcher C.D. Adult and infantile myofibromatosis: a report of three cases affecting the oral cavity. J Oral Pathol Med, 20: 380–4, 1991.
10. Jones A.C., Freedman P.D., Kerpel S.M. Oral myofibromas: a report of 13 cases and review of the literature. J Oral Maxillofac Surg, 52: 870–5, 1994.
11. Lingen M.W., Mostofi R.S., Solt D.B. Myofibromas of the oral cavity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 80: 297–302, 1995.
12. Neville B, Damm DD, Allen CM, Bouquot JE. Oral and Maxillofacial Pathology. Ed. Saunders, Philadelphia; 515-516, 2008.
13. Jalil A.A., Lau S.H. Gingival myofibroma in children: report of 4 cases with immunohistochemical findings. Malaysian J Pathol, 29: 53–56, 2007.
14. Corson M.A., Reed M., Soames J.V., Seymour R.A. Oral myofibromatosis: an unusual cause of gingival overgrowth. J Clin Periodontol, 29: 1048–50, 2002.
15. Vered M., Allon I., Buchner A., Dayan D. Clinico-pathologic correlations of myofibroblastic tumors of the oral cavity. II. Myofibroma and myofibromatosis of the oral soft tissues. J Oral Pathol Med, 36: 304–14, 2007.
16. Hartig G., Koopmann C.Jr., Esclamado R. Infantile myofibromatosis: a commonly misdiagnosed entity. Otolaryngol Head Neck Surg, 109: 753–7, 1993.
17. de Souza Azevedo R., Pires F.R., Coletta R.D., de Almeida O.P., Kowalski L.P., Lopes M.A. Oral myofibromas: report of two cases and review of clinical and histopathologic differential diagnosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 105: e35–e40, 2008.
18. Jordan R.C., Regezi J.A. Oral spindle cell neoplasms: a review of 307 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 95: 717–24, 2003.
19. Fisher C. Myofibroblastic malignancies. Adv Anat Pathol, 11: 190–201, 2004.
20. Takahama A.Jr., Nascimento A.G., Brum M.C., Vargas P.A., Lopes M. A. Low-grade myofibroblastic sarcoma of the parapharyngeal space. Int J Oral Maxillofac Surg, 35: 965–8, 2006.
21. Vilos G.A., Rapidis A.D., Lagogiannis G.D., Apostolidis C. Leiomyosarcomas of the oral tissues: clinicopathologic analysis of 50 cases. J Oral Maxillofac Surg, 63: 1461–77, 2005.
22. de Saint Aubain Somerhausen N., Fletcher C.D. Leiomyosarcoma of soft tissue in children: clinicopathologic analysis of 20 cases. Am J Surg Pathol, 23: 755–63, 1999.
23. Dayan D., Nasrallah V., Vered M. Clinico-pathologic correlations of myofibroblastic tumors of the oral cavity: I. Nodular fasciitis. J Oral Pathol Med, 34: 426–35, 2005.
24. Eversole L.R., Christensen R., Ficarra G., Pierleoni L., Sapp J.P. Nodular fasciitis and solitary fibrous tumor of the oral region: tumors of fibroblast heterogeneity. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 87: 471–6, 1999.
Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.
Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.
Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.
JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.
Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.
BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.
Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.
Scopus: CiteScore 1.8 (2023) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.
Top