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Original Research

Open Access

Total Antioxidant Capacity of Saliva in Children with HIV

  • Vivek Padmanabhan1,*,
  • Kavita Rai2
  • Amitha M Hegde2
  • Sucheta Shetty3

1Department of Pediatric and Preventive Children Dentistry, Vyas Dental College and Hospital

2Department of Pedodontics and Preventive Children Dentistry, A B. Shetty Memorial Institute of Dental Sciences

3Department of Biochemistry, A B. Shetty Memorial Institute of Dental Sciences

DOI: 10.17796/jcpd.34.4.475137x4n8kj6765 Vol.34,Issue 4,July 2010 pp.347-350

Published: 01 July 2010

*Corresponding Author(s): Vivek Padmanabhan E-mail: vivek_pdr@rediffmail.com

Abstract

Several recent reports have indicated high levels of reactive oxygen species, causing oxidative stress, in the pathogenesis of HIV infection. Oxidative stress may lead to enhanced HIV replication in infected cells and may also aggravate the immunodeficiency by reduction of cellular immunity and possibly by increased programmed cell death of lymphocytes. Saliva can constitute a first line of defense against free radical mediated oxidative stress. The use of saliva as a diagnostic fluid has become somewhat of a translational research success story. Technologies are now available enabling saliva to be used to diagnose disease and predict disease progression.

Purpose: The antioxidant capacity of saliva was investigated in 68 children who were divided into two groups. 34 children who were investigated were diagnosed as having HIV infection and the other group consisted of children who reported to the department and served as healthy controls. Total antioxidant capacity of saliva was evaluated by spectrophotometric assay.

Conclusions: The results indicated that the total antioxidant capacity (TAC) of saliva decreased in children with HIV infection. TAC was seen to increase with the age of the children.

Keywords

HIV; Oxidative stress; total antioxidant capacity (TAC)

Cite and Share

Vivek Padmanabhan,Kavita Rai,Amitha M Hegde,Sucheta Shetty. Total Antioxidant Capacity of Saliva in Children with HIV. Journal of Clinical Pediatric Dentistry. 2010. 34(4);347-350.

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