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Original Research

Open Access

Asymmetric Crying Facies with a Couple of Primary Mandibular Central Incisor and 22q11 Deletion

  • Belma Saygili Karagol1,*,
  • Aysegul Zenciroglu1

1Sami Ulus Maternity and Children’s Education and Research Hospital, Division of Neonatology, Ankara, Turkey

DOI: 10.17796/jcpd.34.4.k1p4064047181771 Vol.34,Issue 4,July 2010 pp.343-346

Published: 01 July 2010

*Corresponding Author(s): Belma Saygili Karagol E-mail:


Facial asymmetry present only on crying has been described as a seperate entity and termed asymmetric crying facies. The cause of the facial asymmetry in this disorder is congenital absence or hypoplasia of the depressor anguli oris muscle at the corner of the mouth.

This defect is associated at times with major congenital anomalies, most commonly in the cardiovascular system. Chromosome 22q11 microdeletions in cases with ACF have been reported. We report a newborn infant who had ACF associated with a couple of primary mandibular central incisor teeth and chromosome 22q11 microdeletion. This clinical sign in association with ACF has not been previously described.


asymmetric crying facies; chromosome 22q11 deletion; natal teeth; neonate

Cite and Share

Belma Saygili Karagol,Aysegul Zenciroglu. Asymmetric Crying Facies with a Couple of Primary Mandibular Central Incisor and 22q11 Deletion. Journal of Clinical Pediatric Dentistry. 2010. 34(4);343-346.


1. Cayler GG. Cardiofacial syndrome: congenital heart disease and facial weakness, a hitherto unrecognized association. Arch Dis Child, 44: 69–75,1969.

2. Lahat E, Heyman E, Barkay A, Goldberg M. Asymmetric crying facies and associated congenital anomalies: prospective study and review of the literature. J Child Neurol, 15: 808–810, 2000.

3. Dubnov-Raz G, Merlob P, Geva-Dayan K, Blumenthal D, Finkelstein Y. Increased rate of major birth malformations in infants with neonatal asymmetric crying face. Am J Med Genet Part A, 143A: 305–310, 2007.

4. Perlman M, Reisner SH. Asymmetric crying facies and congenital anomalies. Arch Dis Child, 48: 627–629, 1973.

5. Caksen H, Odabas D, Tuncer O, Kirimi E, Tombul T, Ikbal M, Atas B, Ari Yuca S. A review of 35 cases of asymmetric crying facies. Genet Couns, 15: 159–165, 2004.

6. Innes AM. Asymmetric crying facies and associated congenital anomalies: the contribution of 22q11 microdeletions. J Child Neurol, 16: 1778, 2001.

7. Bawle EV, Conard J, Van Dyke DL, Czarnecki P, Driscoll DA. Seven new cases of Cayler cardiofacial syndrome with chromosome 22q11.2 deletion, including a familial case. Am J Med Genet, 79: 406–410, 1998.

8. Yang HC, Shyur SD, Huang LH, Chang YC, Wen DC, Liang PH, Lin MT. DiGeorge syndrome associated with solitary median maxillary central incisor. Asian Pac J Allergy Immunol, 23(2-3): 159–163, 2005.

9. Hopkin RJ, Schorry EK, Bofinger M, Saal HM. Increased need for medical interventions in infants with velocardiofacial (deletion 22q11) syndrome. J Pediatr, 137: 247–249, 2000.

10. Leung AKC, Robson WLM. Natal teeth: a review. J Natl Med Assoc, 98: 226–228, 2006.

11. de Almaida CM, Gomide MR. Prevalence of natal/neonatal teeth in cleft lip and palate infants. Cleft Palate J, 33: 297–299, 1996.

12. Uzamıs M, Olmez S, Ozturk H. Clinical and ultrastructural study of natal and neonatal teeth. J Clin Pediatr Dent, 173–177, 1999.

13. Marakoglu K, Percin EF, Marakoglu I. Anencephalic infant with cleft palate and natal teeth: a case report. Cleft Palate Craniofac J, 41: 456–458, 2004.

14. Tezenas Du, Montcel S, Mandizabai H, Ayme S, Levy A, Philip N. Prevalence of 22q11 microdeletion. J Med Genet, 33: 719, 1996.

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