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Original Research

Open Access

In vitro Comparison of Self versus Professionally Applied Remineralizing Materials

  • Chutima Trairatvorakul1,*,
  • Napassorn Kangvansurakit2
  • Jarinya Pathomburi2

1Department of Pediatric Dentistry, Faculty of Dentistry, Chulalongkorn University

2Faculty of Dentistry, Chulalongkorn University

DOI: 10.17796/jcpd.34.4.p35436j05010u562 Vol.34,Issue 4,July 2010 pp.323-328

Published: 01 July 2010

*Corresponding Author(s): Chutima Trairatvorakul E-mail:


Objective: To compare the effect of 4 remineralizing materials on the incipient artificial carious lesion and its proximal sound enamel when used with fluoride dentifrice.

Study Design: Models mimicking proximal contact were made, each of which was placed with an artificial carious specimen in contact with a sound enamel specimen. Each carious specimen was treated with one of four materials: glass ionomer cement (GIC), resin modified glass ionomer cement (RMGIC), 5000 ppm sodium fluoride (F-gel), and casein phosphopeptide amorphous calcium phosphate (CPP-ACP). The GIC and RMGIC specimens were thermocycled. Then all specimens were pH-cycled for 5 days with twice a day soaking in 1,000 ppm NaF dentifrice solution. Specimens were examined by polarized light microscopy and lesion area quantified by image analysis.

Results: RMGIC significantly yielded smaller areas of lesion than CPP-ACP and GIC (p<0.05). F-gel reduced more area of lesion than CPP-ACP significantly (p<0.05). In the associated contact, RMGIC significantly reduced the area of lesion better than CPP-ACP (p<0.05).

Conclusions: The most effective remineralizing material in reducing the carious lesion areas was RMGIC followed by F-gel, GIC and CPP-ACP. The demineralization inhibitory effects on the associated sound contact enamel followed the same trend.


remineralization, demineralization, artificial caries, fluoride-releasing material, CPP-ACP, resin modified glass ionomer cement, glass ionomer cement, sodium fluoride gel

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Chutima Trairatvorakul,Napassorn Kangvansurakit,Jarinya Pathomburi. In vitro Comparison of Self versus Professionally Applied Remineralizing Materials. Journal of Clinical Pediatric Dentistry. 2010. 34(4);323-328.


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