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Salivary Sialic Acid Levels and Dental Health In Children with Congenital Heart Disease
1Department of Pedodontics and Preventive Children Dentistry, A.B. Shetty Memorial Institute of Dental Sciences, Derlakatte, Nitte University, Mangalore-575018, Karnataka, India.
*Corresponding Author(s): Hegde AM E-mail: amipedo@yahoo.co.in sushykp@gmail.com
Congenital cardiac disease is one of the most common developmental anomalies in children. Higher caries prevalence and gingivitis compared to healthy children have been shown in children with congenital heart disease which has a significant implication in the medical care of these patients associated with bacteraemia and endocarditis. Sialic acids being terminal sugar components and marker of chronic inflammatory response are found to be present at higher levels in children with poor oral health status. So the present study aimed to evaluate the oral health status and salivary sialic acid levels among the children with congenital heart disease and normal healthy siblings. A total of 71 children with heart diseases aged 6-10 years attending various heart institutes were examined for oral hygiene status, gingival status and dental caries status by using modified WHO oral assessment form. A case-matched control group of 50 children were also examined. Salivary flow rate, pH and sialic acid levels were measured after saliva collection. The results were subjected to Unpaired t test and Pearson’s Correlation Coefficient Test. The salivary pH, salivary flow rate, dental caries status, oral hygiene and the gingival status were significantly compromised with a positive correlation with the sialic acid levels in saliva, leading to increased treatment needs in the study group. Therefore the amount of sialic acid in the saliva can be a useful index of the severity of oral disease
Congenital heart disease, sialic acid, oral health, children.
Hegde AM,Kavita Rai,Sushma KS,Suchetha Shetty. Salivary Sialic Acid Levels and Dental Health In Children with Congenital Heart Disease. Journal of Clinical Pediatric Dentistry. 2012. 36(3);293-296.
1. Rashmi kapoor, Shipra gupta. Prevalence of congenital heart disease, Kanpur, India, Indian Pediatr, 45: 309–311, 2008.
2. Stecksen-Bliks C, Rydberg A, Nyman L, Asplund S and Svanberg C. Dental caries experience in children with congenital heart disease: A case control study. Int. J Pediatr Dent, 14: 94–100, 2004.
3. Sobia Zafar, Soraya Yasin-Harnekar, Allauddin Siddiqi, Fareeha Naz. Oral health status of pediatric cardiac patients-a case controlled study. International Dentistry SA; 10(6): 28–38.
4. Maryam Talebi, Maryam Khordi, Mohammad Mahmoudi, Shaili Alidad, A Study on Oral Health of Children with Cardiac Diseases in Mashhad, Iran in 2004. JODDD, 1(3): 114–118, 2007.
5. PK Nigam, VS Narain, Ajay Kumar. Sialic acid in cardiovascular diseases. Indian J Clin Biochem; 21(1): 54–61, 2006.
6. LK Öztürk, H Furuncuoglu, MH Atala, O Uluköylü, S Akyü and A Yarat. Association between dental-oral health in young adults and salivary glutathione, lipid peroxidation and sialic acid levels and carbonic anhydrase activity. Braz J Medi and Biological Res, 41(11): 956–959, 2008.
7. Rokicki W, Strzalkowski A, Klapcinska B, Danch A and Sobczak A. Antioxidant status in newborns and infants suffering from congenital heart defects. Wiad Lek, 56(7–8): 337–340, 2003.
8. Soben Peter. Essentials of preventive and community dentistry; 9th edition .
9. World Health Organization. Oral Health Survey: Basic methods 4th ed. Geneva.World Health Organization; 1997.
10. Winzler. Determination of serum glycoproteins in methods of biochemical analysis, 2: 298, 1955.
11. Anita Saxena. Congenital heart diseases in India: A status report. Indian J Paediatr, 72(7): 595–598, 2005.
12. Richard Balmer, Georgia Booras et al. The oral health of children considered very high risk for infective endocarrditis. Int J of Ped Dent, 20: 173–178, 2010.
13. D.B.Silva, I.P.R.Souza et al. Knowledge,attitudes and status of oral health in children at risk for infective endocarditis. Int. J Pediat Dent, 12: 124–131, 2002.
14. Hallett KB, Radford DJ and Seow WM. Oral health of children with congenital cardiac diseases: a controlled study. Ped Dent, 14(4): 224–230, 1992.
15. Pollard MA & Curzon MEJ. Dental health and salivary Streptococcus mutans levels in a group of children with heart defects. Int J of Ped Dent, 2: 81–85, 1992.
16. Parry JA, Khan FA. Provision of dental care for medically compromised children in the UK by general practitioners. Int J Pediat Dent, 10: 322–327, 2000
17. Tasioula V, Balmer R, Parsons J. Dental health and treatment in a group of children with congenital heart disease. Pediatr Dent. Jul–Aug; 30(4): 323–328, 2008.
18. A Bardow, B Nyvad, B Nauntofte. Relationships between medication intake, complaints of dry mouth, salivary flow and composition, and the rate of tooth demineralisation in situ. Arch Oral Biol, 46: 413–423, 2001.
19. Karina P. Gopaul, Martin A. Crook. Sialic acid: A novel marker of cardiovascular disease? Clin Biochemistry, July; 39(7): 667–681, 2006.
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