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Open Access

Extreme Tooth Abnormalities and Treatment under General Anesthesia in a Child with chronic GVHD Surviving Relapse of Acute Lymphoblastic Leukemia

  • Maeda S1,*,
  • Suda M2
  • Ishii M2
  • Tomoyasu Y3
  • Higuchi H3
  • Okazaki Y4
  • Egusa M5
  • Miyawaki T2

1Department of Dental Anesthesiology. From Okayama University HospitalDepartment of Dental Anesthesiology and Special Care Dentistry, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

2,Department of Dental Anesthesiology

3,Department of Pediatric Dentistry

4,Special Needs Dentistry

DOI: 10.17796/jcpd.37.2.77xn15vr232646kj Vol.37,Issue 2,March 2013 pp.199-202

Published: 01 March 2013

*Corresponding Author(s): Maeda S E-mail:


Treatment for acute lymphoblastic leukemia (ALL) mainly consists of chemotherapy, irradiation and bone marrow transplantation. In terms of long-term treatment effects, dental abnormalities and chronic graft-versus host disease (GVHD) are problems. We present a patient surviving relapse of ALL at one year of age. He had extreme dental abnormalities and multiple caries. Most of his permanent teeth were abnormal, and multiple caries were observed. Since he had a strong vomiting reaction to dental treatment, general anesthesia was given. During the general anesthesia, much sputum was aspirated because of chronic GVHD. His dental condition was worse than other cases reported previously. Since the survival rate has increased recently, the dental effects of ALL treatment have become significant. Especially, in patients undergoing total body irradiation at under 2 years of age, it is highly likely that dental problems will occur in the future.


Teeth Abnormality Leukemia Graft vs Host Disease, children, General Anesthesia

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Maeda S,Suda M,Ishii M,Tomoyasu Y,Higuchi H,Okazaki Y,Egusa M,Miyawaki T. Extreme Tooth Abnormalities and Treatment under General Anesthesia in a Child with chronic GVHD Surviving Relapse of Acute Lymphoblastic Leukemia. Journal of Clinical Pediatric Dentistry. 2013. 37(2);199-202.


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