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Salivary interleukin-8 levels in children suffering from Type 1 diabetes mellitus

  • Dakovic D1
  • Colic M1
  • Cakic S1
  • Mileusnic I1,*,
  • Hajdukovic Z1
  • Stamatovic N1

1Veljka Dugosevica 22, 11000 Belgrade, Serbia.

DOI: 10.17796/jcpd.37.4.l135531h4542gj66 Vol.37,Issue 4,July 2013 pp.377-380

Published: 01 July 2013

*Corresponding Author(s): Mileusnic I E-mail:


The aim of this study was to investigate the differences between the salivary levels of IL-8 in patients with Type 1 diabetes mellitus (DM) with (DM+P) or without (DM-P) concomitant periodontitis and healthy subjects. The correlations between the levels of these cytokines and clinical periodontal parameters were also established. Methods: Twenty children and adolescents with Type 1 DM (10 diagnosed with periodontitis, 10 presenting no signs of periodontitis) and a control group consisting of 20 healthy children and adolescents aged 7-18 years were recruited for this study. Results: The Salivary IL-8 level was statistically significantly (p<0.005) elevated in subjects with Type 1 DM (474.47 ± 716.76) compared to non-diabetic control group (101.99 ± 68.32). There was no difference (p>0.05) in the salivary IL-8 level when subjects with Type 1 DM with concomitant periodontitis were compared to diabetics without periodontitis. When the salivary IL-8 level in subjects with Type 1 DM was correlated with the clinical parameters, no statistical significance was found. Conclusion: An elevated salivary IL-8 level in subjects with Type 1 DM without concomitant periodontitis plays a major role in the development of diabetic micro and macroangiopathy and pathogenesis of atherosclerosis. Consequently, this may offer a basis for the assessment of risk, prophylaxis and treatment of diabetic complications.


Type 1 diabetes mellitus, periodontitis, children, cytokines, interleukin-8

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Dakovic D,Colic M,Cakic S,Mileusnic I,Hajdukovic Z,Stamatovic N. Salivary interleukin-8 levels in children suffering from Type 1 diabetes mellitus. Journal of Clinical Pediatric Dentistry. 2013. 37(4);377-380.


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