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Original Research

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A Double Blind Randomized Trial of Ketofol Versus Propofol for Endodontic Treatment of Anxious Pediatric Patients

  • Mittal N1,*,
  • Goyal A2
  • Gauba K2
  • Kapur A2
  • Jain K2

1Department of Pedodontics and Preventive Dentistry, Santosh Dental College and Hospital, Ghaziabad, Uttar Pradesh, India

2Department of Anesthesia and Intensive Care in PGIMER, Chandigarh, India.

DOI: 10.17796/jcpd.37.4.thv8372410714342 Vol.37,Issue 4,July 2013 pp.415-420

Published: 01 July 2013

*Corresponding Author(s): Mittal N E-mail: dr.neetipgi@gmail.com

Abstract

To find out the safe and efficient sedative agent for primary molar pulpectomy in uncooperative pediatric patients. Study Design: This double blind randomized trial enrolled 40 anxious and healthy 2-6 year olds. All subjects received IV propofol (1-1.5mg/kg) or ketofol (1-1.5 mg/kg propofol with 0.25mg/kg ketamine) as per group assignment after oral midazolam premedication (0.5 mg/kg). Sedation maintenance was done with propofol infusion at 25-75µg/kg/min titrated to a predefined Worse level as per Houpt’s sedation rating scale. Additional bolus/es was/were administered in the dosage similar to induction dose in case of inadequate sedation. Primary outcomes were intraoperative and postoperative adverse events. Secondary outcomes were vital signs, success of procedure, operator satisfaction, sedation quality, treatment time, recovery time and total propofol dose. Results: Significantly greater incidence of respiratory depression was reported for ketofol group (11/20; 55%) when compared to propofol group (3/20; 15%) (p = 0.008). Desaturation was the most common adverse respiratory event with significantly greater incidence in ketofol group (9/20; 45%) when compared to propofol only group (3/20; 15%) (p = 0.033). No significant differences regarding secondary outcomes were reported in two groups. Conclusion: Both the regimen exhibited similar sedation profile while propofol alone emerged as a safer option.

Keywords

Anxiety, Behavior management, Sedation, Propofol, Ketamine, Ketofol

Cite and Share

Mittal N,Goyal A, Gauba K,Kapur A, Jain K. A Double Blind Randomized Trial of Ketofol Versus Propofol for Endodontic Treatment of Anxious Pediatric Patients. Journal of Clinical Pediatric Dentistry. 2013. 37(4);415-420.

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