Article Data

  • Views 1032
  • Dowloads 191

Original Research

Open Access

Does Casein Phosphopeptid Amorphous Calcium Phosphate Provide Remineralization on White Spot Lesions and Inhibition of Streptococcus mutans?

  • Arzu Aykut-Yetkiner1,*,
  • Nazan Kara1
  • Mustafa Ateş1
  • Nazan Ersin1
  • Fahinur Ertuğrul*1

1University of Ege, Faculty of Dentistry, Department of Pedodontics, Izmir, Turkey.

DOI: 10.17796/jcpd.38.4.b4q401v6m4818215 Vol.38,Issue 4,July 2014 pp.302-306

Published: 01 July 2014

*Corresponding Author(s): Arzu Aykut-Yetkiner E-mail: XXX

Abstract

The aim of this study was to evaluate the remineralization effect of Casein Phosphopeptid Amorphous Calcium Phosphate (CPP-ACP) on white spot lesions (WSL) and its inhibitory effect on Streptococcus mutans colonization. Study design: The study group consisted of 60 children exhibiting at least 1-WSL. Subjects were randomly divided into 2 groups: a test group of using CPP-ACP cream (Tooth Mousse, GC Europe N.V., Leuven, Belgium) and a control group using only fluoride containing toothpaste for a period of 3-months. Baseline WSLs were scored using DIAGNOdent device (KaVo Germany) and the saliva samples were collected to measure S. mutans counts. After the 3-month period the WSLs were again recorded and the saliva sample collection was repeated. Wilcoxon Signed Ranks Test was used for statistical analysis. Results: DIAGNOdent measurements were increased by time (p=0.002) in control group and no statistically significant difference (p=0.217) was found in test group by the 3-month period. In both groups, the mutans counts were decreased in 3-month experimental period. Conclusions: These clinical and laboratory results suggested that CPP-ACP containing cream had a slight remineralization effect on the WSL in the 3-month evaluation period however longer observation is recommended to confirm whether the greater change in WSLs is maintained.

Keywords

Remineralization, DIAGNOdent, CPP-ACP

Cite and Share

Arzu Aykut-Yetkiner,Nazan Kara,Mustafa Ateş,Nazan Ersin,Fahinur Ertuğrul*. Does Casein Phosphopeptid Amorphous Calcium Phosphate Provide Remineralization on White Spot Lesions and Inhibition of Streptococcus mutans?. Journal of Clinical Pediatric Dentistry. 2014. 38(4);302-306.

References

1. Andersson A, Skold-Larsson K, Hallgren A, Petersson LG, Twetman S, Effect of a dental cream containing amorphous cream phosphate complexes on white spot lesion regression assessed by laser fluorescence. Oral Health Prev Dent; 5:229-233,2007.

2. Anttonen V, Seppa L, Hausen H, Clinical study of the use of the laser fluorescence device DIAGNOdent for detection of occlusal caries in children. Caries Res; 37:17-23,2003.

3. Azarpazhooh A; Limeback H, Clinical efficacy of casein derivatives: a systematic review of the literature. JADA; 139:915-924,2008.

4. Beerens MW, van der Veen MH, van Beek H, ten Cate JM, Effects of casein phosphopeptide amorphous calcium fluoride phosphate paste on white spot lesions and dental plaque after orthodontic treatment: a 3-month follow-up. Eur J Oral Sci; 118:610-617,2010.

5. Cai F, Shen P, Morgan MV, Reynolds EC, Remineralization of enamel subsurface lesions in situ by sugar-free lozenges containing casein phosphopeptide-amorphous calcium phosphate. Aust Dent J; 48:240-243,2003.

6. Coykendall, A. L., P. A. Specht, and H. H. Samol, Streptococcus mutans in a wild, sucrose-eating rat population. Infect. Immun; 10:216-219,1974.

7. Erdem AP, Sepet E, Avshalom T, Gutkin V, Steinberg D, Effect of CPP-ACP and APF on Streptococcus mutans biofilm: A laboratory study. Am J Dent; 24: 119-123,2011.

8. Gold 0 G, Jordon H V, Van Houte J, A selective medium for Streptococcus mutans. Arch Oral Biol; 18:1357-1364,1973.

9. Iijima Y, Cai F, Shen P, Walker G., Reynolds C, Reynolds EC, Acid resistance of enamel subsurface lesions remineralized by a sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate. Caries Res; 38:551-556,2004.

10. Jayarajan J, Janardhanam P, Jayakumar P; Deepika, Efficacy of CPP-ACP and CPP-ACPF on enamel remineralization - An in vitro study using scanning electron microscope and DIAGNOdent®. Indian J Dent Res; 22:77-822011.

11. Melrose CA, Appleton J, Lovius BBJ, A scanning electron microscope study of early enamel caries formed in-vivo beneath orthodontic bands. Br J Orthod; 23:43-47,1996.

12. Perch, B., E. Kjems, and T. Ravn, Biochemical and serological properties of Streptococcus mutans from various human and animal sources. Acta Pathol Microbiol Scand Sect B; 82:357-370,1974.

13. Pinheiro I V A, Medeiros M C, Ferreira M A, Lima K, Use of laser fluorescence (DIAGNOdent®) for in vivo diagnosis of occlusal caries: a systematic review. J Minim Interv Dent; 1:45-51,2008.

14. Reynolds EC, Remineralization of enamel subsurface lesions by casein phosphopeptide stabilized calcium phos-phate solution. J Dent Res; 76:1587-1595,1997.

15. Reynolds EC, Anticariogenic complexes of amorphous calcium phosphate stabilized by casein phosphopeptides: a review. Spec Care Dentist; 18:8-16,1998.

16. Reynolds EC, Calcium phosphate-based remineralization systems: scientific evidence? Aust Dent J; 53:268-273,2008.

17. Reynolds EC, Casein phosphopeptide-amorphous calcium phosphate: the scientific evidence. Adv Dent Res; 21:25-29,2009.

18. Reynolds EC, Cai F, Shen P, Walker G.D, Retention in plaque and remineralization of enamel lesion by various forms of calcium in a mouthrinse or sugar-free chewing gum. J Dent Res; 82:206-211,2003.

19. Reynolds EC, Cain CJ, Webber FL, Black CL, Riley PF, Johnson IH, Perich JW, Anticariogenicity of calcium phosphate complexes of tryptic casein phosphopeptides in the rat. J Dent Res; 74:1272-1279,1995.

20. Rocha RO, Ardengi TM, Oliveria LB, Rodrigues CR, Ciamponi AL, In vivo effectiveness of laser fluorescence compared to visual inspection and radiography for the detection of occlusal caries in primary teeth. Caries Res; 37:437-441,2003.

21. Shen P, Cai F, Nowicki A, Vincent J, Reynolds EC, Remineralization of enamel subsurface lesions by sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate. J Dent Res; 80:2066-2070,2001.

22. Shi XQ, Tranaeus S, Angmar-Månsson B, Comparison of QLF and DIAGNOdent for quantification of smooth surface caries. Caries Res; 35:21-26,2001.

23. Sudjalim TR, Woods MG, Manton DJ, Prevention of white spot lesions in orthodontic practice: a contemporary review. Aust Dent J; 51:284-289,2006.

24. Yengopal V, Mickenautsch S, Caries preventive effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP): a meta-analysis. Acta Odontol Scand; 67:321-332,2009.

25. Yoon RK, Best JM. Advances in pediatric dentistry, Dent Clin North Am; 55:419-432,2011. 26. Zero DT, Recaldent--evidence for clinical activity. Adv Dent Res; 21:30-34,2009.

Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Scopus: CiteScore 1.8 (2023) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Submission Turnaround Time

Conferences

Top