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Original Research

Open Access

Assessment of orthodontic treatment needs in patients with β-thalassemia major and sickle cell disease

  • Salmeh Kalbassi1,*,
  • Mohammadreza Younesi2
  • Samira Louni Aligoudarzi3

1Specialist in Orthodontics and Dentofacial Orthopedics, Private clinic in Iran (Tehran, Isfahan), UAE (Dubai) and Oman (Muscat)

2Department of hematology, Tehran university of medical sciences, 1416634793 Tehran, Iran

3Department of hematology, Amiralmomenin diagnostic laboratory, 1563479524 Tehran, Iran

DOI: 10.22514/jocpd.2023.006 Vol.47,Issue 2,March 2023 pp.68-73

Submitted: 09 July 2022 Accepted: 29 September 2022

Published: 03 March 2023

*Corresponding Author(s): Salmeh Kalbassi E-mail: Kalbassi_salmeh@yahoo.com

Abstract

Patients suffering from hemoglobinopathies may suffer from pathogic dental and orofacial features. This study aimed to assess the prevalence of malocclusion and the need for orthodontic treatment in patients with β-thalassemia major (BTM) and sickle cell disease (SCD). The study was conducted on 311 blood transfusion-dependent patients with BTM or SCD and 400 healthy individuals aged 10 to 16. The types of malocclusion were evaluated based on Angle’s classification and Dewey’s modification, and their oral habits were recorded using a questionnaire. The need for orthodontic treatment was assessed through the Dental Health Component of the Index of Orthodontic Treatment Need (IOTN), and the data were compared with normal participants. The Index of Orthodontic Treatment Need-Dental Health Component (IOTN-DHC) assessment showed that patients had a higher prevalence of objective need for treatment (IOTN grades 4 and 5) compared to healthy children. The prevalence of class II malocclusion was significantly higher in patients. Patients showed significantly less Angle’s Class I malocclusion compared to normal participants. Oral habits were presented in 61%, 64.15% and 62.4% of normal participants, BTM and SCD patients, respectively. The higher prevalence of Angle’s class II malocclusion and higher percentage of IOTN grade 4 and 5 among BTM and SCD patients reveal the importance of early orthodontic assessment and intervention in children with BMT and SDC.


Keywords

Orthodontic treatment need; Sickle cell disease; Beta thalassemia major


Cite and Share

Salmeh Kalbassi,Mohammadreza Younesi,Samira Louni Aligoudarzi. Assessment of orthodontic treatment needs in patients with β-thalassemia major and sickle cell disease. Journal of Clinical Pediatric Dentistry. 2023. 47(2);68-73.

References

[1] Kinalski M, Sarkis-Onofre R, dos Santos MBF. Inherited bleeding disorders in oral procedures. Assessment of prophylactic and therapeutic protocols: a scoping review. Australian Dental Journal. 2021; 66: 150–158.

[2] Kalbassi S, Chiong FW, Cheau HY, Chew WH. Quantitative three-dimensional assessment of buccal alveolar bone thickness with dental cone-beam computed tomography. Biomedical Research. 2017; 28: 8154–8160.

[3] Shivakumar VH, Garg R, Tegginamani AS, Gupta VV. Dental considerations of hereditary bleeding disorders in children: an overview. Oral and Maxillofacial Pathology Journal. 2022; 13: 36–43.

[4] Utsugisawa T, Kanno H. Hemoglobinopathies. Japanese Journal of Transfusion and Cell Therapy. 2022; 68: 3–11.

[5] Nasiri A, Rahimi Z, Vaisi-Raygani A. Hemoglobinopathies in Iran: an updated review. International Journal of Hematology-Oncology and Stem Cell Research. 2020; 14: 140.

[6] Aksu T, Unal S. Thalassemia. Trends in Pediatrics. 2021; 2: 1–7.

[7] Wu H-W, Rahim N, Mbadiwe N, Khayat S, da Fonseca MA, Peters E, et al. Vaso-occlusive pain crisis mimicking mandibular abscess in an adolescent with sickle cell disease. Journal of Pediatric Hematology/Oncology. 2022; 44: e450–e452.

[8] Farooq F, Mogayzel PJ, Lanzkron S, Haywood C, Strouse JJ. Comparison of us federal and foundation funding of research for sickle cell disease and cystic fibrosis and factors associated with research productivity. JAMA Network Open. 2020; 3: e201737.

[9] Kalbassi S, Younesi MR, Asgary V. Comparative evaluation of oral and dento-maxillofacial manifestation of patients with sickle cell diseases and beta thalassemia major. Hematology. 2018; 23: 373–378.

[10] Vanderhave KL, Perkins CA, Scannell B, Brighton BK. Orthopaedic manifestations of sickle cell disease. Journal of the American Academy of Orthopaedic Surgeons. 2018; 26: 94–101.

[11] Nancy A, Sukinah A, Maram A, Sara A, Hiba A, Manar A. Dental and skeletal manifestation of sickle-cell anaemia and thalassemia in saudi arabia; a systematic review. International Journal of Pharmaceutical Research and Allied Sciences. 2021; 10: 1–7.

[12] Alves PVM, Alves DKM, de Souza MMG, Torres SR. Orthodontic treatment of patients with sickle-cell anemia. The Angle Orthodontist. 2006; 76: 269–273.

[13] Alighieri C, Bettens K, Bonte K, Roche N, Van Lierde K. Oral habits in children with cleft (lip and) palate: a pilot study. International Journal of Phoniatrics, Speech Therapy and Communication Pathology. 2019; 71: 191–196.

[14] Mohan Das U, Reddy D, LNU V. Prevalence of malocclusion among school children in Bangalore, India. International Journal of Clinical Pediatric Dentistry. 2008; 1: 10–12.

[15] Singh G. Textbook of orthodontics. 3rd edn. JP Medical Ltd: London. 2015.

[16] Janson G, Lenza EB, Francisco R, Aliaga-Del Castillo A, Garib D, Lenza MA. Dentoskeletal and soft tissue changes in class II subdivision treatment with asymmetric extraction protocols. Progress in Orthodontics. 2017; 18: 39.

[17] Laganà G, Masucci C, Fabi F, Bollero P, Cozza P. Prevalence of malocclusions, oral habits and orthodontic treatment need in a 7- to 15-year-old schoolchildren population in Tirana. Progress in Orthodontics. 2013; 14: 12.

[18] Gupta DK, Singh SP, Utreja A, Verma S. Prevalence of malocclusion and assessment of treatment needs in β-thalassemia major children. Progress in orthodontics. 2016; 17: 1–6.

[19] Avsever IH, Orhan K, Özen T, Ü K GS. Evaluation of mandibular bone structure in sickle cell anemia patients. Güihane Medical Journal. 2015; 57: 11–15.

[20] Santos PRB, Machado PDC, Passos CP, Aguiar MC, Nascimento RJM, Campos MIG. Prevalence of orofacial alterations in sickle cell disease: a review of literature. Brazilian Journal of Oral Sciences. 2013; 12: 153–157.

[21] Lukusa Kazadi A, Ngiyulu RM, Gini-Ehungu JL, Mbuyi-Muamba JM, Aloni MN. Factors associated with growth retardation in children suffering from sickle cell anemia: first report from central Africa. Anemia. 2017; 2017: 1–6.

[22] Demirbaş AK, Ergün S, Güneri P, Aktener BO, Boyacıoğlu H. Mandibular bone changes in sickle cell anemia: fractal analysis. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2008; 106: e41–e48.

[23] Eslamipour F, Afshari Z, Najimi A. Prevalence of orthodontic treatment need in permanent dentition of Iranian population: A systematic review and meta-analysis of observational studies. Dental Research Journal. 2018; 15: 1.

[24] Borzabadi-Farahani A, Borzabadi-Farahani A, Eslamipour F. Malocclusion and occlusal traits in an urban Iranian population. An epidemiological study of 11- to 14-year-old children. The European Journal of Orthodontics. 2009; 31: 477–484.

[25] Arabiun H, Mirzaye M, Dehghani-Nazhvani A, Ajami S, Faridi S, Bahrpeima F. The prevalence of malocclusion among 14–18 years old students in Shiraz. Journal of Oral Health and Oral Epidemiology. 2014; 3: 8–11.

[26] Kalbassi S, Louni Aligoudarzi S. Evaluation of occlusion and orthodontic treatment needs of iranian children using index for orthodontic treatment need (IOTN): a cross-sectional study and review of the literature. Journal of Research in Medical and Dental Science. 2019; 7: 39–44.

[27] Kerosuo H, Heikinheimo K, Nyström M, Väkiparta M. Outcome and long-term stability of an early orthodontic treatment strategy in public health care. European Journal of Orthodontics. 2013; 35: 183–189.

[28] Danaei SM, Oshagh M, Khoda MO, Karamifar AA, Maram SS, Borhan-Haghighi Z. Orthodontic treatment needs assessment of 14- to 18-year-old students in Shiraz, Iran. World Journal of Orthodontics. 2010; 11: e19–25.

[29] Chestnutt IG, Burden DJ, Steele JG, Pitts NB, Nuttall NM, Morris AJ. The orthodontic condition of children in the United Kingdom, 2003. British Dental Journal. 2006; 200: 609–612.

[30] Souames M, Bassigny F, Zenati N, Riordan PJ, Boy-Lefevre ML. Orthodontic treatment need in French schoolchildren: an epidemiological study using the index of orthodontic treatment need. The European Journal of Orthodontics. 2006; 28: 605–609.

[31] Bilgic F, Gelgor IE, Celebi AA. Malocclusion prevalence and orthodontic treatment need in central Anatolian adolescents compared to European and other nations’ adolescents. Dental Press Journal of Orthodontics. 2015; 20: 75–81.

[32] Omer ZQ, Karim HO. Prevalence of malocclusion and orthodontic treatment need in a sample of 12–15-year-old Kurdish schoolchildren in Ranyia district. Erbil Dental Journal. 2018; 1: 61–70.

[33] Jeelani W, Sher U, Ahmed M. Nature, and severity of dental malocclusion in children suffering from transfusion-dependent β-thalassemia major. Dental Press Journal of Orthodontics. 2021; 25: 26e1–26e9.


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