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Original Research

Open Access

Evaluation of growth status of children with non-syndromic oral clefts

  • Nan Li1
  • Kuan Zhang1
  • Xi Chen2
  • Jie Cui1
  • Xue Han1
  • Dongjin Zhai1
  • Mengying Wang2
  • Zhibo Zhou1
  • Gaoshuang Chen1
  • Hongping Zhu1,*,

1Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, 100081 Beijing, China

2Department of Epidemiology and Biostatistics, School of Public Health, Peking University, 100191 Beijing, China

DOI: 10.22514/jocpd.2023.023 Vol.47,Issue 3,May 2023 pp.59-63

Submitted: 17 September 2022 Accepted: 25 November 2022

Published: 03 May 2023

*Corresponding Author(s): Hongping Zhu E-mail:


To assess the growth status of children with non-syndromic oral clefts (NSOC) and explore potential influencing factors. The data of NSOC children aged ≤5 years hospitalized between December 2018 and June 2020 were retrieved and evaluated, including their height, weight, NSOC subtypes and demographic characteristics before reparative surgeries. The growth status of the children was assessed using height-for-age Z-score (HAZ), weight-for-age Z-score (WAZ) and weight-for-height Z-score (WHZ). In total, 504 NSOC children (271 females & 233 males) were included. The proportion of stunting (HAZ <−2), underweight (WAZ <−2) and wasting (WHZ <−2) was 4.96%, 5.16% and 3.97%, respectively. In addition, we observed that HAZ and WAZ decreased with increasing age (both p< 0.01). Moreover, non-syndromic cleft palate only (NSCP) and non-syndromic cleft lip and palate (NSCLP) were associated with lower HAZ and WAZ compared with non-syndromic cleft lip only (NSCL) (all p < 0.01), while NSCLP was associated with a lower WHZ compared with NSCL (p < 0.01). The growth retardation and low weight rate of NSOC children under 5 years old were higher than the national average level and differed by the age of NSOC children and disease subtypes. Further improvements are warranted to promote the growth status of the NSOC-affected children.


Non-syndromic oral cleft; Child; Growth; Z-score

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Nan Li,Kuan Zhang,Xi Chen,Jie Cui,Xue Han,Dongjin Zhai,Mengying Wang,Zhibo Zhou,Gaoshuang Chen,Hongping Zhu. Evaluation of growth status of children with non-syndromic oral clefts. Journal of Clinical Pediatric Dentistry. 2023. 47(3);59-63.


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