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Dental manifestation and management in a patient with combined pituitary hormone deficiency: a two-year case report

  • Sara D. Alzanbaqi1
  • Sara M. Bagher2,*,

1Department of Pediatric Dentistry, King Abdulaziz University, 21589 Jeddah, Saudi Arabia

2Department of Pediatric Dentistry, Faculty of Dentistry, King Abdulaziz University, 21589 Jeddah, Saudi Arabia

DOI: 10.22514/jocpd.2023.069 Vol.47,Issue 5,September 2023 pp.181-185

Submitted: 21 December 2022 Accepted: 17 February 2023

Published: 03 September 2023

*Corresponding Author(s): Sara M. Bagher E-mail:


Combined pituitary hormone deficiency (CPHD) is a rare disorder caused by a complete absence of the anterior pituitary gland hormones. The Dental manifestation, managmnet and two-year-follow-up of a case of a 12-year-old patient with CPHD is reported in this paper. A 12-year-old male patient with medical history of congenital CPHD and vitamin D deficiency presented for dental treatment. The patient looked tired and younger than his chronological age. Intraoral examination revealed good oral hygiene, generalized edematous gingiva, physiological pigmentation and high maxillary labial frenum attachment. The occlusion examination, showed class I molars, 2 mm overjet and 90% overbite. Single anterior tooth #21 crossbite with 1.5 mm diastema. Also, Miller’s class I recession in tooth #31 with a probing depth of 1 mm, and grade I mobility. The treatment plan was formulated in phases, and the primary physician consultation was obtained and a clearance for dental treatment with a recommendation to double the hydrocortisone dose before a stressful dental procedure was recommended. Preventive and restorative programs were planned and provided. Then, the lower lingual holding arch was provided after the extraction of mandibular primary canines with composite turbo, and tooth #21 crossbite was corrected using a nance appliance with Z spring. Finally, the patient was recommended to attend follow-up visits every three months. During which the preventive program was reinforced and the restorative treatments were reevaluated. At the 2-year-follow-up satisfactory and stable aesthetic and functional results were obtained. This report highlights the oral manifestations, the value of establishing a preventive program, and restorative, and orthodontic interventions among patients with CPHD.


Adrenal insufficiency; Growth hormone; Hypothyroidism; Oral manifestation; Panhypopituitarism

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Sara D. Alzanbaqi,Sara M. Bagher. Dental manifestation and management in a patient with combined pituitary hormone deficiency: a two-year case report. Journal of Clinical Pediatric Dentistry. 2023. 47(5);181-185.


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