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Systematic Reviews

Open Access

Adverse effects of articaine versus lidocaine in pediatric dentistry: a meta-analysis

  • Ling Li1
  • Da-lei Sun1,*,

1Department of Stomatology, Hangzhou Normal University Affiliated Hospital, 310000 Hangzhou, Zhejiang, China

DOI: 10.22514/jocpd.2023.078 Vol.47,Issue 6,November 2023 pp.21-29

Submitted: 13 January 2023 Accepted: 28 February 2023

Published: 03 November 2023

*Corresponding Author(s): Da-lei Sun E-mail:


Over the last few years, numerous reports have lauded the efficacy of articaine hydrochloride as a local anesthetic (LA) in dental procedures. Numerous studies have shown that articaine outperforms lidocaine in various aspects of dental treatment, leading to its widespread adoption in both adults and children. Despite the publications of comparative studies, there remains a dearth of systematic reviews examining the adverse effects of articaine versus lidocaine in randomized controlled trials. The aim was to assess the available research on the adverse effects of articaine and lidocaine in pediatric dentistry. A comprehensive search was conducted on Cochrane Library, Pubmed, Chinese Biomedical Literature Database (CBM), Embase, Web of Science and China National Knowledge Infrastructure (CNKI). Randomized controlled trials (RCT) that compared articaine with lidocaine in pediatric dentistry were included. Methodological quality assessment and risk of bias were determined for each of the included studies. The Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach was used to assess the strength of evidence for every research. A total of 333 studies were identified through electronic searches. After conducting primary and secondary assessments, eight studies were included for the final qualitative analysis. We found no difference in the probability of adverse reactions between articaine and lidocaine after treatment in pediatric patients (risk ratio (RR) = 1.08, 95% confidence interval (CI) (0.54–2.15), p = 0.83). However, a high heterogeneity was reported among the outcomes in the investigated studies (I2 = 57%), and the strength of the evidence was classified as “moderate” based on the GRADE approach. Besides, we found no significant difference in the probability of postoperative pain, postoperative soft tissue injury and edema between articaine and lidocaine in pediatric patients following treatment. There was moderate quality evidence suggesting no difference in the occurrence of adverse events between articaine and lidocaine when used for pediatric dental procedures.


Articaine; Children; Inferior alveolar nerve block; Infiltration; Lidocaine

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Ling Li,Da-lei Sun. Adverse effects of articaine versus lidocaine in pediatric dentistry: a meta-analysis. Journal of Clinical Pediatric Dentistry. 2023. 47(6);21-29.


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