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Original Research

Open Access

Relationship between time to hemostasis and outcomes of pulpotomy using iRoot BP Plus in symptomatic young permanent teeth: a prospective study

  • Min Sheng1,2
  • Denghui Zhang2
  • Jing Yan2,3
  • Weiqin Li1,2,*,

1Department of Stomatology, Shaoxing Yuecheng People’s Hospital, 312000 Shaoxing, Zhejiang, China

2Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, 310000 Hangzhou, Zhejiang, China

3Shaoxing Stomatological Hospital, 312000 Shaoxing, Zhejiang, China

DOI: 10.22514/jocpd.2023.088 Vol.47,Issue 6,November 2023 pp.142-149

Submitted: 15 March 2023 Accepted: 12 May 2023

Published: 03 November 2023

*Corresponding Author(s): Weiqin Li E-mail:


The aim was to investigate the relationship between time to hemostasis and pulpotomy outcomes with the use of iRoot BP Plus (Innovative Bioceramics, Vancouver, Canada) for young permanent teeth of patients aged from 7 to 12 with symptomatic irreversible pulpitis and evaluate the outcomes of pulpotomy. The present study was a prospective cohort study. Two hundred and six young permanent teeth with symptomatic irreversible pulpitis underwent pulpotomy with the use of iRoot BP Plus. All patients underwent pulpotomy in accordance with a standardized protocol. Patients were postoperatively re-called after 3, 6, 12 months. Successful cases were defined according to clinical and radiographic evaluations. Main outcome measures included tooth position, cave shape, previous restoration, preoperative symptoms, time to hemostasis and outcomes. On the basis of univariate linear regression model, the relationships between time to hemostasis was evaluated, and p < 0.05 indicated a difference that achieved statistical significance. One hundred and ninety-three teeth can be evaluated after a follow-up for 6 to 36 months. The mean age of subjects was 9.43 ± 1.51 years. The overall clinical and radiographic success rate of pulpotomy reached 71.5% (138/193). After adjusting potential confounders (age, sex, previous restoration), non-linear relationship was detected between time to hemostasis and pulpotomy outcomes whose point was 4 minutes. The relationship between time to hemostasis and pulpotomy outcomes is non-linear. Pulpotomy outcomes was negatively related with time to hemostasis when time to hemostasis is more than 4 minutes.


Pulpotomy; Young permanent teeth; Hemostasis; Relationship

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Min Sheng,Denghui Zhang,Jing Yan,Weiqin Li. Relationship between time to hemostasis and outcomes of pulpotomy using iRoot BP Plus in symptomatic young permanent teeth: a prospective study. Journal of Clinical Pediatric Dentistry. 2023. 47(6);142-149.


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