Article Data

  • Views 663
  • Dowloads 172

Original Research

Open Access

Dental and skeletal maturation of Chinese male children with unilateral cleft lip and palate

  • Ying Guo1,†
  • Huiquan Yang1,†
  • Jing Pan1
  • Qianhui Ren1
  • Chenjie Yang1,*,
  • Fang Ji1,*,

1Department of Orthodontics, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, 200011 Shanghai, China

DOI: 10.22514/jocpd.2024.032 Vol.48,Issue 2,March 2024 pp.40-46

Submitted: 28 March 2023 Accepted: 13 July 2023

Published: 03 March 2024

*Corresponding Author(s): Chenjie Yang E-mail: YANGCJ1830@sh9hospital.org.cn
*Corresponding Author(s): Fang Ji E-mail: smilefang98@alumni.sjtu.edu.cn

† These authors contributed equally.

Abstract

The aim of this study was to determine whether the relationship between dental age (DA), cervical stage (CS) and chronological age (CA) in Chinese male children with unilateral cleft lip and palate (UCLP) is similar to that of children without clefts. Panoramic and cephalometric radiographs of 105 male UCLP patients, aged from 8 to 16 years, were collected and compared to 210 age-matched healthy control males. The Demirjian and cervical vertebral maturation (CVM) methods were used to visually examine the radiographs and Spearman’s correlation analysis was used to identify differences between the two groups with regards to CS, DA and CA. There was a significant positive correlation between DA and CA in both groups and the mean CA-DA difference was significantly higher in children with UCLP when compared to controls (0.319 vs. 0.003, p < 0.05). A significant delay in tooth development was detected in UCLP children from 10 to 12 years-of-age. Both the UCLP and control groups showed high correlations between CS and DA. Calcification stage D appeared only before CS3; however, from CS5 to 6, all teeth have almost completed their maturation phase. Chinese male UCLP patients are likely to experience delayed tooth development compared to healthy controls, especially during the fast-growing period. Evaluating the stages of tooth mineralization could represent a rapid method to assess growth potential.


Keywords

Cephalometric radiograph; Demirjian method; Cervical vertebral maturation method; Cleft lip and palate


Cite and Share

Ying Guo,Huiquan Yang,Jing Pan,Qianhui Ren,Chenjie Yang,Fang Ji. Dental and skeletal maturation of Chinese male children with unilateral cleft lip and palate. Journal of Clinical Pediatric Dentistry. 2024. 48(2);40-46.

References

[1] Zhu Y, Miao H, Zeng Q, Li B, Wang D, Yu X, et al. Prevalence of cleft lip and/or cleft palate in Guangdong province, China, 2015–2018: a spatio-temporal descriptive analysis. BMJ Open. 2021; 11: e046430.

[2] Mossey PA, Little J, Munger RG, Dixon MJ, Shaw WC. Cleft lip and palate. The Lancet. 2009; 374: 1773–1785.

[3] Moore RN. Principles of dentofacial orthopedics. Seminars in Orthodontics. 1997; 3: 212–221.

[4] Cameron N. The measurement of human growth. In Cameron N, Schell LM. (ed.) Human Growth and Development (pp. 317–345). 3rd edn. Academic Press: London. 2022.

[5] Manzoor Mughal A, Hassan N, Ahmed A. Bone age assessment methods: a critical review. Pakistan Journal of Medical Sciences. 2014; 30: 211–215.

[6] Baccetti T, Franchi L, McNamara JA. The cervical vertebral maturation (CVM) method for the assessment of optimal treatment timing in dentofacial orthopedics. Seminars in Orthodontics. 2005; 11: 119–129.

[7] Szemraj A, Wojtaszek-Słomińska A, Racka-Pilszak B. Is the cervical vertebral maturation (CVM) method effective enough to replace the hand-wrist maturation (HWM) method in determining skeletal maturation?—A systematic review. European Journal of Radiology. 2018; 102: 125–128.

[8] Ferrillo M, Curci C, Roccuzzo A, Migliario M, Invernizzi M, de Sire A. Reliability of cervical vertebral maturation compared to hand-wrist for skeletal maturation assessment in growing subjects: a systematic review. Journal of Back and Musculoskeletal Rehabilitation. 2021; 34: 925–936.

[9] Lucchese A, Bondemark L, Farronato M, Rubini G, Gherlone EF, Lo Giudice A, et al. Efficacy of the cervical vertebral maturation method: a systematic review. Turkish Journal of Orthodontics. 2022; 35: 55–66.

[10] Demirjian A, Goldstein H, Tanner JM. A new system of dental age assessment. Human Biology. 1973; 45: 211–227.

[11] Fonseca-Souza G, de Oliveira LB, Wambier LM, Scariot R, Feltrin-Souza J. Tooth abnormalities associated with non-syndromic cleft lip and palate: systematic review and meta-analysis. Clinical Oral Investigations. 2022; 26: 5089–5103.

[12] Sander AK, Grau E, Bartella AK, Kloss-Brandstätter A, Neuhaus M, Zimmerer R, et al. Dental anomalies and their therapeutic implications: retrospective assessment of a frequent finding in patients with cleft lip and palate. BMC Oral Health. 2022; 22: 553.

[13] Shen C, Guo R, Li W. Enamel defects in permanent teeth of patients with cleft lip and palate: a cross-sectional study. Journal of International Medical Research. 2019; 47: 2084–2096.

[14] Berrocal C, Terrero-Pérez Á, Peralta-Mamani M, Fischer Rubira-Bullen IR, Honório HM, de Carvalho IMM, et al. Cervical vertebrae anomalies and cleft lip and palate: a systematic review and meta-analysis. Dentomaxillofacial Radiology. 2019; 48: 20190085.

[15] Yang C, Shi J, Chen Z, Yu Q. Assessment of skeletal maturation in male children with unilateral cleft lip and palate. The Journal of Craniofacial Surgery. 2022; 33: e588–e592.

[16] Wu X, Kuang W, Zheng J, Yang Z, Ren M, Yang R, et al. Skeletal maturation in patients with cleft lip and/or palate: a systematic review. The Cleft Palate-Craniofacial Journal. 2022; 59: 307–319.

[17] Cesur E, Altug AT, Toygar-Memikoglu U, Gumru-Celikel D, Tagrikulu B, Erbay E. Assessment of sella turcica area and skeletal maturation patterns of children with unilateral cleft lip and palate. Orthodontics & Craniofacial Research. 2018; 21: 78–83.

[18] Thierens LAM, Manalili L, De Roo N, Verdonck A, De Llano-Pérula MC, De Pauw GAM. Assessment of craniofacial maturation in preadolescents with cleft lip and/or palate using the cervical vertebral maturation method. Clinical Oral Investigations. 2021; 25: 4851–4859.

[19] Ozturk T, Gumus H, Ozturk G. Are dental maturation, skeletal maturation, and chronological age associated with complete cleft lip and palate? The Cleft Palate-Craniofacial Journal. 2021; 58: 275–283.

[20] Akarsu-Guven B, Karakaya J, Ozgur F, Aksu M. Growth-related changes of skeletal and upper-airway features in bilateral cleft lip and palate patients. American Journal of Orthodontics and Dentofacial Orthopedics. 2015; 148: 576–586.

[21] Markovic E, Marinkovic N, Zelic K, Milovanovic P, Djuric M, Nedeljkovic N. Dental age estimation according to European formula and Willems method: comparison between children with and without cleft lip and palate. The Cleft Palate-Craniofacial Journal. 2021; 58: 612–618.

[22] Kimbrough SB, Parris WG, Williams RA, Harris EF. A retrospective mixed longitudinal study of tooth formation in children with clefts. The Cleft Palate-Craniofacial Journal. 2020; 57: 938–947.

[23] Van Dyck J, Cadenas de Llano-Pérula M, Willems G, Verdonck A. Dental development in cleft lip and palate patients: a systematic review. Forensic Science International. 2019; 300: 63–74.

[24] Lai MC, King NM, Wong HM. Dental development of Chinese children with cleft lip and palate. The Cleft Palate-Craniofacial Journal. 2008; 45: 289–296.

[25] Ranta R. A review of tooth formation in children with cleft lip/palate. American Journal of Orthodontics and Dentofacial Orthopedics. 1986; 90: 11–18.

[26] Zheng Y, Jiang C, Ma H, Yin N, Zhai J, Tong H, et al. Three-dimensional measurement of the zygomatic-maxillary complex in unilateral cleft lip and palate patients with maxillary retrusion. The Journal of Craniofacial Surgery. 2022; 33: e179–e182.

[27] Vila-Blanco N, Varas-Quintana P, Tomás I, Carreira MJ. A systematic overview of dental methods for age assessment in living individuals: from traditional to artificial intelligence-based approaches. International Journal of Legal Medicine. 2023; 137: 1117–1146.


Abstracted / indexed in

Science Citation Index Expanded (SciSearch) Created as SCI in 1964, Science Citation Index Expanded now indexes over 9,500 of the world’s most impactful journals across 178 scientific disciplines. More than 53 million records and 1.18 billion cited references date back from 1900 to present.

Biological Abstracts Easily discover critical journal coverage of the life sciences with Biological Abstracts, produced by the Web of Science Group, with topics ranging from botany to microbiology to pharmacology. Including BIOSIS indexing and MeSH terms, specialized indexing in Biological Abstracts helps you to discover more accurate, context-sensitive results.

Google Scholar Google Scholar is a freely accessible web search engine that indexes the full text or metadata of scholarly literature across an array of publishing formats and disciplines.

JournalSeek Genamics JournalSeek is the largest completely categorized database of freely available journal information available on the internet. The database presently contains 39226 titles. Journal information includes the description (aims and scope), journal abbreviation, journal homepage link, subject category and ISSN.

Current Contents - Clinical Medicine Current Contents - Clinical Medicine provides easy access to complete tables of contents, abstracts, bibliographic information and all other significant items in recently published issues from over 1,000 leading journals in clinical medicine.

BIOSIS Previews BIOSIS Previews is an English-language, bibliographic database service, with abstracts and citation indexing. It is part of Clarivate Analytics Web of Science suite. BIOSIS Previews indexes data from 1926 to the present.

Journal Citation Reports/Science Edition Journal Citation Reports/Science Edition aims to evaluate a journal’s value from multiple perspectives including the journal impact factor, descriptive data about a journal’s open access content as well as contributing authors, and provide readers a transparent and publisher-neutral data & statistics information about the journal.

Scopus: CiteScore 2.0 (2022) Scopus is Elsevier's abstract and citation database launched in 2004. Scopus covers nearly 36,377 titles (22,794 active titles and 13,583 Inactive titles) from approximately 11,678 publishers, of which 34,346 are peer-reviewed journals in top-level subject fields: life sciences, social sciences, physical sciences and health sciences.

Submission Turnaround Time

Conferences

Top