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Original Research

Open Access

Dental and skeletal maturation of Chinese male children with unilateral cleft lip and palate

  • Ying Guo1,†
  • Huiquan Yang1,†
  • Jing Pan1
  • Qianhui Ren1
  • Chenjie Yang1,*,
  • Fang Ji1,*,

1Department of Orthodontics, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, 200011 Shanghai, China

DOI: 10.22514/jocpd.2024.032 Vol.48,Issue 2,March 2024 pp.40-46

Submitted: 28 March 2023 Accepted: 13 July 2023

Published: 03 March 2024

*Corresponding Author(s): Chenjie Yang E-mail:
*Corresponding Author(s): Fang Ji E-mail:

† These authors contributed equally.


The aim of this study was to determine whether the relationship between dental age (DA), cervical stage (CS) and chronological age (CA) in Chinese male children with unilateral cleft lip and palate (UCLP) is similar to that of children without clefts. Panoramic and cephalometric radiographs of 105 male UCLP patients, aged from 8 to 16 years, were collected and compared to 210 age-matched healthy control males. The Demirjian and cervical vertebral maturation (CVM) methods were used to visually examine the radiographs and Spearman’s correlation analysis was used to identify differences between the two groups with regards to CS, DA and CA. There was a significant positive correlation between DA and CA in both groups and the mean CA-DA difference was significantly higher in children with UCLP when compared to controls (0.319 vs. 0.003, p < 0.05). A significant delay in tooth development was detected in UCLP children from 10 to 12 years-of-age. Both the UCLP and control groups showed high correlations between CS and DA. Calcification stage D appeared only before CS3; however, from CS5 to 6, all teeth have almost completed their maturation phase. Chinese male UCLP patients are likely to experience delayed tooth development compared to healthy controls, especially during the fast-growing period. Evaluating the stages of tooth mineralization could represent a rapid method to assess growth potential.


Cephalometric radiograph; Demirjian method; Cervical vertebral maturation method; Cleft lip and palate

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Ying Guo,Huiquan Yang,Jing Pan,Qianhui Ren,Chenjie Yang,Fang Ji. Dental and skeletal maturation of Chinese male children with unilateral cleft lip and palate. Journal of Clinical Pediatric Dentistry. 2024. 48(2);40-46.


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