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Assessing modalities used to alleviate postoperative pain in children receiving dental treatment under general anaesthesia: a systematic review

  • Shivaranjhany Sivakumar1,*,
  • Annapurny Venkiteswaran2
  • Muhammad Aidil Roslan1
  • Sabri Musa1,*,

1Department of Paediatric Dentistry & Orthodontics, Faculty of Dentistry, Universiti Malaya, 50603 Kuala Lumpur, Malaysia

2Centre of Paediatric Dentistry & Orthodontics, Faculty of Dentistry, MARA University of Technology, 47000 Sungai Buloh, Selangor, Malaysia

DOI: 10.22514/jocpd.2024.054 Vol.48,Issue 3,May 2024 pp.15-23

Submitted: 16 August 2023 Accepted: 18 October 2023

Published: 03 May 2024

*Corresponding Author(s): Shivaranjhany Sivakumar E-mail:
*Corresponding Author(s): Sabri Musa E-mail:


Postoperative pain is generally a novel experience among paediatric patients. Topical anaesthetics, distraction procedures, and buffering of anaesthetic solutions have been used in reducing the postoperative pain. In this review, the authors assessed various modalities used to alleviate postoperative pain in children’s dental treatment under general anaesthesia. Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) protocol were strictly adhered to in this systematic review. Specific keywords including postoperative pain, general anaesthesia, children, and dental extraction were used in the search for relevant randomized control trial studies in Web of Science, Scopus, and PubMed, and included articles published until June 2021. From a total of 191 abstracts, 21 were reviewed. From the six studies with the usage of non-steroidal anti-inflammatory drugs (NSAIDs) alone or in combination with paracetamol, four observed that the preoperative use of NSAIDs alone or in combination was better than paracetamol alone, one discovered preoperative intravenous paracetamol was better than postoperative intravenous paracetamol, and the remaining study found no difference among various groups. Of two studies comparing the usage of non-steroidal anti-inflammatory drugs with opioid analgesics, one stated intravenous fentanyl in combination was better, while the other study found no difference among groups. The results obtained in this review can be utilized by physicians to control postoperative pain in children undergoing dental treatment under general anaesthesia.


Postoperative pain; General anaesthesia; Dental extraction; Children

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Shivaranjhany Sivakumar,Annapurny Venkiteswaran,Muhammad Aidil Roslan,Sabri Musa. Assessing modalities used to alleviate postoperative pain in children receiving dental treatment under general anaesthesia: a systematic review. Journal of Clinical Pediatric Dentistry. 2024. 48(3);15-23.


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