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Open Access

Evaluation of Papacarie®, Carie-Care™, BRIX3000™ and conventional hand instrumentation for caries removal in primary teeth: a randomized control study

  • Nikita Gupta1,†
  • Nikhil Marwah1,†
  • Anant Nigam1
  • Satish Vishwanathaiah2,†
  • Noura Alessa3
  • Asma Almeslet4
  • Khalid Alhakami5
  • Tazeen Dawood6
  • Feras Majed Masha7
  • Prabahdevi C Maganur2,*,†,

1Department of pedodontics and preventive dentistry, Mahatma Gandhi Dental college and hospital, 302022 Jaipur, India

2Department of preventive dental sciences, Division of pediatric dentistry, College of Dentistry, Jazan University, 45142 Jazan, Saudi Arabia

3Department of pediatric dentistry and orthodontics, Dental college, King Saud University, 11545 Riyadh, Saudi Arabia

4Department of Oral maxillofacial surgery and diagnostic sciences, College of Medicine and Dentistry, Riyadh Elm University, 12734 Riyadh, Saudi Arabia

5King Abdulaziz medical city of national guard health affairs, 21423 Jeddah, Saudi Arabia

6Department of Preventive dental sciences, Division of periodontics, College of Dentistry, Jazan university, 45142 Jazan, Saudi Arabia

7The middle sector, Ministry of Health, General Directorate for Health, 84211 Jazan, Saudi Arabia

DOI: 10.22514/jocpd.2024.066 Vol.48,Issue 3,May 2024 pp.131-138

Submitted: 25 August 2023 Accepted: 30 October 2023

Published: 03 May 2024

*Corresponding Author(s): Prabahdevi C Maganur E-mail:

† These authors contributed equally.


In the current odontological era, carious lesions are removed while tooth tissue is preserved. Most of these ideals are met by chemomechanical caries removal (CMCR) methods, which are easy and comfortable to use, differentiate and eliminate infected tissues, minimize pressure, vibration and heat, and are cost-effective. This study examines the efficacy of commercially available CMCR agents, namely Papacarie®, Carie-Care™ and BRIX3000™, and a conventional hand instrumentation method for caries removal in deciduous molars in terms of time consumption, ease of application, and pain perception. For this randomized clinical trial, 120 children aged 4 to 9 years were selected and randomly allocated to four groups of 30 patients each. Time consumption, ease of application, and pain perception were evaluated at three intervals: pre-, during- and post-caries removal, using Wong-Baker FACES (WBF) Pain Rating Scale and the Face, Legs, Activity, Cry, Consolability (FLACC) scale. The results showed that among the compared materials and conventional hand instrumentation technique, Carie-Care™ was statistically found to be the least time-consuming with a p-value of 0.019, have the least pain perception with a p-value of 0.02, and was clinically the best with respect to manipulation and handling. While all three CMCR agents aid in the removal of carious tissue, Carie-Care™ was the most effective based on time consumption, pain perception and simplicity of administration.


BRIX3000™; Carie-Care™; Chemomechanical caries removal; Pain perception; Papacarie®

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Nikita Gupta,Nikhil Marwah,Anant Nigam,Satish Vishwanathaiah,Noura Alessa,Asma Almeslet,Khalid Alhakami,Tazeen Dawood,Feras Majed Masha,Prabahdevi C Maganur. Evaluation of Papacarie®, Carie-Care™, BRIX3000™ and conventional hand instrumentation for caries removal in primary teeth: a randomized control study. Journal of Clinical Pediatric Dentistry. 2024. 48(3);131-138.


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