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Original Research

Open Access

Antimicrobial effect of two fluoride-releasing adhesive tapes on Streptococcus mutans biofilm

  • Ok Hyung Nam1,2,†
  • Tae-Young Park3,†
  • Seo-Rin Jeong4
  • Jonghyun Shin5
  • Myeong-Kwan Jih6,*,

1Department of Pediatric Dentistry, School of Dentistry, Kyung Hee University, 02447 Seoul, Republic of Korea

2Department of Pediatric Dentistry, Kyung Hee University, College of Dentistry, Kyung Hee University Medical Center, 02447 Seoul, Republic of Korea

3Department of Conservative Dentistry, School of Dentistry, Chosun University, 61452 Gwangju, Republic of Korea

4Department of Orthodontics, School of Dentistry, Chosun University, 61452 Gwangju, Republic of Korea

5Department of Pediatric Dentistry, School of Dentistry, Pusan National University, 50612 Yangsan, Republic of Korea

6Department of Pediatric Dentistry, School of Dentistry, Chosun University, 61452 Gwangju, Republic of Korea

DOI: 10.22514/jocpd.2024.086 Vol.48,Issue 4,July 2024 pp.132-138

Submitted: 27 June 2023 Accepted: 25 August 2023

Published: 03 July 2024

*Corresponding Author(s): Myeong-Kwan Jih E-mail:

† These authors contributed equally.


Fluoride-releasing adhesive tapes have been developed as a new fluoride delivery agent. However, application as caries prevention agents remains underexplored. This study aimed at evaluating the antimicrobial activity of two fluoride-releasing adhesive tapes against S. mutans biofilm. Two polyvinyl alcohol (PVA) tapes were investigated: (i) a fluoride-PVA (F-PVA) tape, (ii) a pullulan incorporated F-PVA (PF-PVA) tape. S. mutan strains were cultured and treated with the tapes. Antimicrobial effects were evaluated using the agar diffusion test, field-emission scanning electron microscopy (FE-SEM), and confocal laser scanning microscopy (CLSM). F-PVA tapes showed higher inhibition-zone diameters than PF-PVA at 48 h and 72 h. However, there were no significant differences (p > 0.05) between the effects of F-PVA and PF-PVA. The bio-volume of S. mutans and extracellular polymeric substances significantly decreased in the F-PVA tapes than in the PF-PVA tapes (p < 0.05). FE-SEM micrographs revealed less S. mutans colonization in F-PVA. F-PVA exhibited better antimicrobial activity against S. mutans than PF-PVA.


Cariogenic biofilm; Dental caries; Fluoride; Polyvinyl alcohol tape; Pullulan

Cite and Share

Ok Hyung Nam,Tae-Young Park,Seo-Rin Jeong,Jonghyun Shin,Myeong-Kwan Jih. Antimicrobial effect of two fluoride-releasing adhesive tapes on Streptococcus mutans biofilm. Journal of Clinical Pediatric Dentistry. 2024. 48(4);132-138.


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