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Research progress of proteomics in congenital craniofacial anomalies

  • Shujie Hou1,2,3
  • Xuqin Liang4
  • Yuhua Jiao2,5
  • Boxi Yan6
  • Kangying Liu4
  • Hongmei Lin7
  • Yi Ding4
  • Huimei Huang8
  • Jieni Zhang1,3,*,
  • Huaxiang Zhao2,5,*,

1Department of Orthodontics, Peking University School and Hospital of Stomatology, 100081 Beijing, China

2Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, 710004 Xi’an, Shaanxi, China

3National Center of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory for Digital Stomatology, Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health, NMPA Key Laboratory for Dental Materials, 100081 Beijing, China

4Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi’an Jiaotong University, 710061 Xi’an, Shaanxi, China

5Department of Orthodontics, College of Stomatology, Xi’an Jiaotong University, 710004 Xi’an, Shaanxi, China

6Second Clinical Division, Peking University School and Hospital of Stomatology, 100020 Beijing, China

7Department of Pediatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, 710004 Xi’an, Shaanxi, China

8Department of Nephrology, Xi’an Children’s Hospital, The Affiliated Children’s Hospital of Xi’an Jiaotong University, 710003 Xi’an, Shaanxi, China

DOI: 10.22514/jocpd.2024.122 Vol.48,Issue 6,November 2024 pp.1-11

Submitted: 29 November 2023 Accepted: 21 March 2024

Published: 03 November 2024

*Corresponding Author(s): Jieni Zhang E-mail: sd88383511@126.com
*Corresponding Author(s): Huaxiang Zhao E-mail: huaxiangzhao@xjtu.edu.cn

Abstract

Congenital craniofacial anomalies (CFAs) are among the most common birth defects, significantly affecting the appearance, oral function and mental health of patients. These anomalies are etiologically complex, involving genetics, environmental factors and gene-environment interactions. While genetic studies have identified numerous potential causal genes/risk loci for CFAs, the pathogenic mechanisms still largely remain elusive. Proteomics, the large-scale analysis of proteins, offers a comprehensive view of disease pathogenesis and their systemic effects. During the past two decades, the application of proteomics in CFA research has uncovered many biomarkers for early diagnosis and shed light on underlying mechanisms driving these anomalies. Here, we review the advancements and contributions of proteomics to congenital CFA research, outlining technological advances, novel findings from human body fluid proteomics, and integrative multi-omics approaches.


Keywords

Craniofacial anomaly; Proteomics; Mass spectrometry; Human body fluid proteomics; Research progress


Cite and Share

Shujie Hou,Xuqin Liang,Yuhua Jiao,Boxi Yan,Kangying Liu,Hongmei Lin,Yi Ding,Huimei Huang,Jieni Zhang,Huaxiang Zhao. Research progress of proteomics in congenital craniofacial anomalies. Journal of Clinical Pediatric Dentistry. 2024. 48(6);1-11.

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