Title
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Assessment of growth & development, dental caries, and dental development in children with congenital heart disease
1Department of Pediatric Dentistry, Atatürk University Faculty of Dentistry, 25240 Erzurum, Turkey
DOI: 10.22514/jocpd.2025.056 Vol.49,Issue 3,May 2025 pp.107-114
Submitted: 24 June 2024 Accepted: 06 September 2024
Published: 03 May 2025
*Corresponding Author(s): Fatma Saraç E-mail: saracfatma@atauni.edu.tr
Background: Congenital heart disease (CHD) may affect children’s growth and development, as well as dental health. Although oral conditions in children with CHD have been studied, the impact of CHD on dental development and dental age (DA) remains limited. This study aimed to investigate the relationship between growth-development, dental caries, and dental age in children with CHD and compare them with healthy children. Methods: A cross-sectional study was conducted involving 108 children diagnosed with CHD and 111 healthy controls. s. Chronological age (CA) was calculated from clinical records. DA was estimated using Cameriere’s European formula based on digital panoramic radiographs. Clinical data including plaque index (PI) and dental caries indices (dmft/dft/DMFT) were collected. Statistical analyses included Mann-Whitney U and Spearman correlation tests (α = 0.05). Results: There was no significant difference in CA or dental caries scores between groups (p > 0.05), but PI scores were significantly higher in the CHD group (p < 0.001). The mean DA in the CHD group (9.2 ± 2.5) compared to controls (10.1 ± 2.5) (p = 0.009). No significant difference was found in DA between cyanotic and acyanotic CHD types. Conclusions: Children with CHD showed delayed dental age despite having similar chronological age, BMI, and dental caries scores compared to healthy peers. CHD should be considered a potential factor in assessing dental development, especially in the context of growth and systemic disease.
Congenital heart disease; Dental age; Growth & development
Fatma Saraç,Sera Şimşek Derelioğlu. Assessment of growth & development, dental caries, and dental development in children with congenital heart disease. Journal of Clinical Pediatric Dentistry. 2025. 49(3);107-114.
[1] Hoffman JI, Kaplan S. The incidence of congenital heart disease. Journal of the American college of cardiology. 2002; 39: 1890–1900.
[2] Kernell K, Sydsjö G, Bladh M, Nielsen NE, Josefsson A. Congenital heart disease in men—birth characteristics and reproduction: a national cohort study. BMC Pregnancy and Childbirth. 2014; 14: 187.
[3] Sivertsen TB, Aßmus J, Greve G, Åstrøm AN, Skeie MS. Oral health among children with congenital heart defects in Western Norway. European Archives of Paediatric Dentistry. 2016; 17: 397–406.
[4] Ali HM, Mustafa M, Hasabalrasol S, Elshazali OH, Nasir EF, Ali RW, et al. Presence of plaque, gingivitis and caries in Sudanese children with congenital heart defects. Clinical Oral Investigations. 2017; 21: 1299–1307.
[5] Mandalenakis Z, Giang KW, Eriksson P, Liden H, Synnergren M, Wåhlander H, et al. Survival in children with congenital heart disease: have we reached a peak at 97%? Journal of the American Heart Association. 2020; 9: e017704.
[6] Francis DK, Smith J, Saljuqi T, Watling RM. Oral protein calorie supplementation for children with chronic disease. Cochrane Database of Systematic Reviews. 2015; 2015: CD001914.
[7] Moynihan P. Dietary therapy in chronically sick children: dental health considerations. Quintessence International. 2006; 37: 444–448.
[8] Klingberg G, Hallberg U. Oral health—not a priority issue a grounded theory analysis of barriers for young patients with disabilities to receive oral health care on the same premise as others. European Journal of Oral Sciences. 2012; 120: 232–238.
[9] Mohamed Ali H, Mustafa M, Suliman S, Elshazali OH, Ali RW, Berggreen E. Inflammatory mediators in saliva and gingival fluid of children with congenital heart defect. Oral Diseases. 2020; 26: 1053–1061.
[10] Varan B, Tokel K, Yilmaz G. Malnutrition and growth failure in cyanotic and acyanotic congenital heart disease with and without pulmonary hypertension. Archives of Disease in Childhood. 1999; 81: 49–52.
[11] Michiels C. Physiological and pathological responses to hypoxia. The American Journal of Pathology. 2004; 164: 1875–1882.
[12] Prokop-Piotrkowska M, Marszałek-Dziuba K, Moszczyńska E, Szalecki M, Jurkiewicz E. Traditional and new methods of bone age assessment-an overview. Journal of Clinical Research in Pediatric Endocrinology. 2021; 13: 251–262.
[13] Cameriere R, De Angelis D, Ferrante L, Scarpino F, Cingolani M. Age estimation in children by measurement of open apices in teeth: a European formula. International Journal of Legal Medicine. 2007; 121: 449–453.
[14] Nolla CM. The development of permanent teeth: doctoral dissertation [master’s thesis]. University of Michigan. 1952.
[15] Gleiser I, Hunt Jr EE. The permanent mandibular first molar: its calcification, eruption and decay. American Journal of Physical Anthropology. 1955; 13: 253–283.
[16] Bodrumlu EH, Demiriz L, Toprak S. Relationship between severe early childhood caries and dental development. European Journal of Paediatric Dentistry. 2018; 19: 156–160.
[17] Magat G. Assessment of maturation stages and the accuracy of age estimation methods in a Turkish population: a comparative study. Imaging Science in Dentistry. 2022; 52: 83–91.
[18] Holderbaum R. Comparison among dental, skeletal and chronological development in HIV-positive children: a radiographic study. Brazilian Oral Research. 2005; 19: 209–215.
[19] Emeksiz C, Yilmaz N, Tüzüner T, Baygin O. Dental age estimation with two different methods in paediatric patients with hypothyroidism. Archives of Oral Biology. 2022; 139: 105450.
[20] Adler P, Wegner H, Bohatka L. Influence of age and duration of diabetes on dental development in diabetic children. Journal of Dental Research. 1973; 52: 535–537.
[21] Cantekin K, Cantekin I, Torun Y. Comprehensive dental evaluation of children with congenital or acquired heart disease. Cardiology in the Young. 2013; 23: 705–710.
[22] Liu Y, Zhu J, Zhang H, Jiang Y, Wang H, Yu J, et al. Dental caries status and related factors among 5-year-old children in Shanghai. BMC Oral Health. 2024; 24: 459.
[23] Schulz-Weidner N, Logeswaran T, Schlenz MA, Krämer N, Bulski JC. Parental awareness of oral health and nutritional behavior in children with congenital heart diseases compared to healthy children. International Journal of Environmental Research and Public Health. 2020; 17: 7057.
[24] Sezer B, Çarıkçıoğlu B. Accuracy of the London Atlas, Haavikko’s Method and Cameriere’s European Formula of dental age estimation in Turkish children. Legal Medicine. 2022; 54: 101991.
[25] Ustarez A, Silva DR, Roberts G, Jayaraman J. Dental Age estimation standards for Hispanic children and adolescents in California. Forensic Sciences. 2022; 2: 565–573.
[26] Saraç F, Derelioğlu SŞ, Şengül F, Laloğlu F, Ceviz N. The evaluation of oral health condition and oral and dental care in children with congenital heart disease. Journal of Clinical Medicine. 2023; 12: 3674.
[27] Haas NA, Schirmer KR. Guidelines for the management of congenital heart diseases in childhood and adolescence. Cardiology in the Young. 2017; 27: S1–S105.
[28] Warnes CA, Williams RG, Bashore TM, Child JS, Connolly HM, Dearani JA, et al. ACC/AHA 2008 guidelines for the management of adults with congenital heart disease: a report of the American College of Cardiology/American Heart Association task force on practice guidelines (writing committee to develop guidelines on the management of adults with congenital heart disease): developed in collaboration with the american society of echocardiography, heart rhythm society, international society for adult congenital heart disease, society for cardiovascular angiography and interventions, and society of thoracic surgeons. Circulation. 2008; 118: e714–e833.
[29] World Health Organization. Oral health surveys: basic methods. 5th edn. World Health Organization: Geneva. 2013.
[30] Löe H. The gingival index, the plaque index and the retention index systems. The Journal of Periodontology. 1967; 38: 610–616.
[31] Neyzi O, Bundak R, Gökçay G, Günöz H, Furman A, Darendeliler F, et al. Reference values for weight, height, head circumference, and body mass index in Turkish children. Journal of Clinical Research in Pediatric Endocrinology. 2015; 7: 280–293.
[32] Tuteja M, Bahirwani S, Balaji P, Shah B, Daryani D, Kaul R. Radiation induced hypoplasia of the mandible and retarded tooth development. Journal of Indian Academy of Oral Medicine and Radiology. 2010; 22: 229–231.
[33] Brook A. Multilevel complex interactions between genetic, epigenetic and environmental factors in the aetiology of anomalies of dental development. Archives of Oral Biology. 2009; 54: S3–S17.
[34] Tasioula V, Balmer R, Parsons J. Dental health and treatment in a group of children with congenital heart disease. Pediatric Dentistry. 2008; 30: 323–328.
[35] Suma G, Usha M, Ambika G. Oral health status of normal children and those affiliated with cardiac diseases. The Journal of clinical Pediatric Dentistry. 2011; 35: 315–318.
[36] da Fonseca MA, Evans M, Teske D, Thikkurissy S, Amini H. The impact of oral health on the quality of life of young patients with congenital cardiac disease. Cardiology in the Young. 2009; 19: 252–256.
[37] Stecksén-Blicks C, Rydberg A, Nyman L, Asplund S, Svanberg C. Dental caries experience in children with congenital heart disease: a case-control study. International Journal of Clinical Pediatric Dentistry. 2004; 14: 94–100.
[38] Hallett K, Radford D, Seow W. Oral health of children with congenital cardiac diseases: a controlled study. Paediatric Dentistry. 1992; 14: 224–230.
[39] Rushani D, Kaufman JS, Ionescu-Ittu R, Mackie AS, Pilote L, Therrien J, et al. Infective endocarditis in children with congenital heart disease: cumulative incidence and predictors. Circulation. 2013; 128: 1412–1419.
[40] Mack KB, Phillips C, Jain N, Koroluk LD. Relationship between body mass index percentile and skeletal maturation and dental development in orthodontic patients. American Journal of Orthodontics and Dentofacial Orthopedics. 2013; 143: 228–234.
[41] Bagis EE, Derelioglu SS, Sengül F, Yılmaz S. The effect of the treatment of severe early childhood caries on growth-development and quality of life. Children. 2023; 10: 411.
[42] Suvarna R, Rai K, Hegde A. Oral health of children with congenital heart disease following preventive treatment. The Journal of Clinical Pediatric Dentistry. 2011; 36: 93–98.
[43] Giannakoulas G, Dimopoulos K, Engel R, Goktekin O, Kucukdurmaz Z, Vatankulu MA, et al. Burden of coronary artery disease in adults with congenital heart disease and its relation to congenital and traditional heart risk factors. The American Journal of Cardiology. 2009; 103: 1445–1450.
[44] Pemberton VL, McCrindle BW, Barkin S, Daniels SR, Barlow SE, Binns HJ, et al. Report of the national heart, lung, and blood ınstitute’s working group on obesity and other cardiovascular risk factors in congenital heart disease. Circulation. 2010; 121: 1153–1159.
[45] Van Dyke T, van Winkelhoff A. Infection and inflammatory mechanisms. Journal of Clinical Periodontology. 2013; 40: S1–S7.
[46] Ozveren N, Serindere G, Meric P, Cameriere R. A comparison of the accuracy of Willems’ and Cameriere’s methods based on panoramic radiography. Forensic Science International. 2019; 302: 109912.
[47] Hilgers KK, Akridge M, Scheetz JP, Kinane DE. Childhood obesity and dental development. Pediatric Dentistry. 2006; 28: 18–22.
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